Business combinations (Details Textual) - USD ($)	Oct. 14, 2015	Jun. 30, 2016	Dec. 31, 2015	Oct. 31, 2015	Jun. 30, 2015	Dec. 31, 2014
Business Acquisition [Line Items]
Goodwill		$ 14,799,000,000	$ 14,787,000,000		$ 14,723,000,000	$ 14,788,000,000
Dezima [Member]
Business Acquisition [Line Items]
Maximum additional consideration due contingent on certain milestones	$ 1,250,000,000.00			$ 1,250,000,000.00
Estimated fair values of contingent consideration obligations	110,000,000
Indefinite-lived intangible assets - IPR&D	400,000,000
Goodwill	108,000,000
Deferred tax liabilities	$ 100,000,000