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Note 3 - Significant Accounting Policies - Research and Development Expense (Details) - General and Administrative Expense [Member] - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Research and development cost $ 46,262 $ 76,736 $ 87,081 $ 118,531
Research and Development, Salaries [Member]        
Research and development cost 25,654 51,473 62,680 91,079
Research and Development, Other Costs [Member]        
Research and development cost $ 20,608 $ 25,263 $ 24,401 $ 27,452