0000315066-21-001396.txt : 20210223 0000315066-21-001396.hdr.sgml : 20210223 20210223095137 ACCESSION NUMBER: 0000315066-21-001396 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20210219 FILED AS OF DATE: 20210223 DATE AS OF CHANGE: 20210223 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: FMR LLC CENTRAL INDEX KEY: 0000315066 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 001-38722 FILM NUMBER: 21663417 BUSINESS ADDRESS: STREET 1: 245 SUMMER STREET CITY: BOSTON STATE: MA ZIP: 02210 BUSINESS PHONE: 6175706339 MAIL ADDRESS: STREET 1: 245 SUMMER STREET CITY: BOSTON STATE: MA ZIP: 02210 FORMER NAME: FORMER CONFORMED NAME: FMR CORP DATE OF NAME CHANGE: 19920717 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: Orchard Therapeutics plc CENTRAL INDEX KEY: 0001748907 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 000000000 STATE OF INCORPORATION: X0 FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 108 CANNON STREET CITY: LONDON STATE: X0 ZIP: EC4N 6EU BUSINESS PHONE: 011-44-0-203-3846700 MAIL ADDRESS: STREET 1: 108 CANNON STREET CITY: LONDON STATE: X0 ZIP: EC4N 6EU FORMER COMPANY: FORMER CONFORMED NAME: Orchard Rx Ltd DATE OF NAME CHANGE: 20180802 4 1 primary_doc.xml PRIMARY DOCUMENT X0306 4 2021-02-19 0 0001748907 Orchard Therapeutics plc ORTX 0000315066 FMR LLC 245 SUMMER STREET BOSTON MA 02210 0 0 1 1 See Remark 1 Ordinary shares 2021-02-19 4 C 0 409852 D 4099540 I By F-Prime Capital Partners Healthcare Fund IV LP Ordinary shares 2021-02-19 4 C 0 409852 D 4099540 I By F-Prime Capital Partners Healthcare Fund IV-A LP American Depository Shares 2021-02-19 4 C 0 409852 A Ordinary Shares 409852 1000000 I By F-Prime Capital Partners Healthcare Fund IV LP American Depository Shares 2021-02-19 4 C 0 409852 A Ordinary Shares 409852 1000000 I By F-Prime Capital Partners Healthcare Fund IV-A LP On February 19, 2021, F-Prime Capital Partners Healthcare Fund IV LP and F-Prime Capital Partners Healthcare Fund IV-A LP each converted 409,852 Ordinary Shares to American Depository Shares. Remark 1: Abigail P. Johnson is a Director, the Chairman and the Chief Executive Officer of FMR LLC. Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B shareholders have entered into a shareholders' voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders' voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC. The address of Abigail P. Johnson is c/o FMR LLC, 245 Summer Street, Boston, MA 02110. Remark 2: The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, the undersigned are the beneficial owners of any securities reported herein. Remark 3: The general partner of F-Prime Capital Partners Healthcare Fund IV LP is F-Prime Capital Partners Healthcare Advisors Fund IV LP (FPCPHA). The general partner of F-Prime Capital Partners Healthcare Fund IV-A LP is F-Prime Capital Partners Healthcare Advisors Fund IV-A LP (FPCPHA IV-A). FPCPHA and FPCPHA IV-A are solely managed by Impresa Management LLC, the managing member of their general partner and their investment manager. Impresa Management LLC is owned, directly or indirectly, by various shareholders and employees of FMR LLC, including certain members of the Johnson family. Kevin M. Meagher, Duly authorized under Powers of Attorney, by and on behalf of FMR LLC and its direct and indirect subsidiaries, and Abigail P. Johnson 2021-02-23