8-K/A

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K/A

(Amendment No. 1)

CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): July 21, 2008

SCHERING-PLOUGH CORPORATION

(Exact Name of Registrant as Specified in its Charter)

New Jersey
(State or Other Jurisdiction of
Incorporation) 1-6571
(Commission File Number) 22-1918501
(IRS Employer
Identification Number)

2000 Galloping Hill Road
Kenilworth, NJ 07033
(Address of Principal Executive Office)

Registrant’s telephone number, including area code: (908) 298-4000

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

o     Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o     Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o     Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o     Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

EXPLANATORY NOTE

     Schering-Plough is filing an amendment to its 8-K filed earlier today to furnish, as Exhibit 99.4., a press release issued by The University of Oxford Clinical Trial Service Unit and Epidemiological Studies Unit titled “Independent Analyses of the SEAS, SHARP and IMPROVE-IT Studies of Ezetimibe.” The exhibit was omitted from the 8-K filed earlier today due to technical difficulties.

Item 9.01 Financial Statements and Exhibits

(d) Exhibits

     99.4 Press release dated July 21, 2008 titled “Independent Analyses of the SEAS, SHARP and IMPROVE-IT Studies of Ezetimibe”

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Schering-Plough Corporation

By:	/s/ Steven H. Koehler
	Steven H. Koehler
	Vice President and Controller

Date: July 21, 2008

Exhibit Index

Exhibit
Number	Description
99.4	Press release dated July, 2008 titled “Independent Analysis of the SEAS, SHARP and IMPROVE-IT studies of Ezetimibe”

EX-99.4

CTSU Clinical Trial Service Unit &
Epidemiological Studies Unit

Press Release

EMBARGO: 18.00/6pm BST, Monday 21 July 2008

University of Oxford

Nuffield Department of

Clinical Medicine

CTSU, Richard Doll Building,
Old Road Campus,
Roosevelt Drive,
Oxford OX3 7LF, UK
Tel: +44-(0)-1865-743743
Fax: +44-(0)-1865-743985
Website: www.ctsu.ox.ac.uk

Independent analyses of the SEAS, SHARP and IMPROVE-IT studies of ezetimibe

The University of Oxford Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) proposed that the hypothesis-generating results of the SEAS trial of ezetimibe should be tested by reviewing the combined cancer results from the SHARP and IMPROVE-IT trials of ezetimibe, and reporting on the overall findings to the relevant regulatory authorities, independently of the drug manufacturers.

The two hypothesis-testing trials (SHARP and IMPROVE-IT) contain about four times as many cancers as the SEAS trial. They do not confirm the hypothesis raised by the SEAS trial that treatment increases the overall risk of developing cancer. In addition, there is no increase with time in the relative risk (active vs placebo) suggested by the cancer incidence and mortality from all 3 trials together (or just from the pair of hypothesis-testing trials). Consequently, the SEAS, SHARP and IMPROVE-IT trials do not provide credible evidence of any adverse effect on cancer.

Allocation to 5 years of substantial LDL-cholesterol lowering by a statin has been shown previously to have no apparent effect on cancer. The Cholesterol Treatment Trialists’ collaboration has published results (Lancet 2005;366: 1267-78) based on 90,000 patients randomised evenly between statin and control. Based on 5530 patients with cancer onset after randomisation, the statin vs control relative risk was 0.997 (with 95% confidence interval 0.95-1.05; not significant). Of these patients, 2163 died of their cancer during the scheduled follow-up period; the relative risk for cancer death was 1.01 (with 95% confidence interval 0.91-1.12; not significant).

In the final results from the SEAS trial, there appears to be a small increase in total cancer incidence in the group allocated ezetimibe + statin, but this is based on only 102 vs 67 cancer cases (including 39 vs 23 fatal cases) and there is no significant increase in any particular type of cancer.

/more

Two other large trials of ezetimibe + statin are still in progress: (i) SHARP (ezetimibe + simvastatin vs placebo in 9,000 patients; recruitment completed, but treatment and follow-up continuing) and (ii) IMPROVE-IT (ezetimibe + simvastatin vs placebo + simvastatin in 11,000 patients; recruitment continues towards an eventual target of 18,000 patients). Together, they have already accumulated about four times as many cancers as SEAS (see table). If treatment really did increase total cancer by 50% then this would have been clearly apparent in the hypothesis testing SHARP & IMPROVE-IT trials. Instead, there was no evidence of any increase in cancer (see table).

Cancer events	Active		Control
Hypothesis generator: SEAS		102		67
Hypothesis test: SHARP & IMPROVE-IT*		313		326

* 216 active vs 254 control non-fatal cases and 97 vs 72 fatal cases.

If there were a real adverse effect on cancer incidence or cancer mortality then previous experience with the epidemiology of cancer (ie, with other causes of the disease in humans) strongly suggests that the relative risk (active versus control) should grow bigger with time, but it does not, whether the hypothesis-testing trials are considered separately or all 3 trials are considered together.

Note: The University of Oxford Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) has decades of experience in cancer epidemiology, in vascular and other trials, and in collaborative meta-analyses of trials. Although CTSU is conducting the SHARP trial, it is doing so independently of the source of funding, and has a policy of not accepting honoraria or consultancy fees. This report to regulatory authorities on the analyses of SEAS, SHARP and IMPROVE-IT was initiated, conducted and interpreted by the CTSU independently of any source of funding.

End

For more information, please, refer to the press release issued by the SEAS investigators today.

Contact: Andrew Trehearne, CTSU, +44 (0)1865-743960, +44 (0)789-404-2600

Co-directors: Rory Collins FMed Sci FRCP BHF Professor of Medicine and Epidemiology Sir Richard Peto FRS Hon FRCP Professor of Medical Statistics and Epidemiology

Jane Armitage FFPH FRCP	Colin Baigent FFPH FRCP	Jillian Boreham PhD	John Cairns FRS	Zhengming Chen MBBS DPhil	Michael Clarke DPhil
Reader in Clinical Epidemiology	Professor of Epidemiology	Senior Research Fellow	Emeritus Professor of Cancer	Professor of Epidemiology	Professor of Clinical Epidemiology
Robert Clarke FFPH FRCP	Sarah Darby PhD	Christina Davies BMBCh MSc	Alison Halliday FRCS	Martin Landray PhD MRCP	Christine Marsden PhD
Reader in Epidemiology	Professor of Medical Statistics	Senior Research Fellow	Consultant in Vascular Surgery	Reader in Epidemiology	Unit Administrator
Sarah Parish DPhil	Max Parkin MD	Susan Richards DPhil	David Simpson OBE Hon MFPH	Alan Young DPhil	Sarah Clark, Karen Kourellias &
Senior Research Fellow	Honorary Senior Research Fellow	Senior Research Fellow	Director, IATH	Head of Systems Development	Martin Radley: Lab Management