11-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 11-K

FOR ANNUAL REPORTS OF EMPLOYEE STOCK PURCHASE, SAVINGS

AND SIMILAR PLANS PURSUANT TO SECTION 15(d) OF THE

SECURITIES EXCHANGE ACT OF 1934

(Mark One):

ýANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2021

OR

oTRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from ______ to ______

Commission File Number 1-10706

A.Full title of the plan and the address of the plan, if different from that of the issuer named below:

COMERICA INCORPORATED PREFERRED SAVINGS PLAN

B.Name of issuer of the securities held pursuant to the plan and the address of its principal executive office:

COMERICA INCORPORATED

Comerica Bank Tower

1717 Main Street

MC 6404

Dallas, Texas 75201

Comerica Incorporated Preferred Savings Plan

Table of Contents

Financial Statements and Supplemental Schedule

Audited Financial Statements:

Supplemental Schedule*

Exhibit 23.1 Consent of Independent Registered Public Accounting Firm (Ernst & Young LLP)

* Other schedules required by Section 2520.103-10 of the Department of Labor's Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974 are not applicable and have been omitted.

FINANCIAL STATEMENTS AND SUPPLEMENTAL SCHEDULE

Comerica Incorporated Preferred Savings Plan

Years Ended December 31, 2021 and 2020

with Report of Independent Registered Public Accounting Firm

Comerica Incorporated Preferred Savings Plan

Financial Statements and Supplemental Schedule

Years Ended December 31, 2021 and 2020

Contents

Report of Independent Registered Public Accounting Firm	1
Audited Financial Statements
Statements of Net Assets Available for Benefits	2
Statements of Changes in Net Assets Available for Benefits	3
Notes to Financial Statements	4
Supplemental Schedule
Schedule H, Line 4i - Schedule of Assets (Held at End of Year)	10

Report of Independent Registered Public Accounting Firm

To the Plan Participants and the Plan Administrator of Comerica Incorporated Preferred Savings Plan

Opinion on the Financial Statements

We have audited the accompanying statements of net assets available for benefits of Comerica Incorporated Preferred Savings Plan (the Plan) as of December 31, 2021 and 2020, and the related statements of changes in net assets available for benefits for the years then ended, and the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the net assets available for benefits of the Plan at December 31, 2021 and 2020, and the changes in its net assets available for benefits for the years then ended, in conformity with U.S. generally accepted accounting principles.

Basis for Opinion

These financial statements are the responsibility of the Plan’s management. Our responsibility is to express an opinion on the Plan’s financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Plan in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Plan is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Plan’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

Supplemental Schedule Required by ERISA

The accompanying supplemental schedule of assets (held at end of year) as of December 31, 2021 (referred to as the "supplemental schedule"), has been subjected to audit procedures performed in conjunction with the audit of the Plan’s financial statements. The information in the supplemental schedule is the responsibility of the Plan’s management. Our audit procedures included determining whether the information reconciles to the financial statements or the underlying accounting and other records, as applicable, and performing procedures to test the completeness and accuracy of the information presented in the supplemental schedule. In forming our opinion on the information, we evaluated whether such information, including its form and content, is presented in conformity with the Department of Labor’s Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974. In our opinion, the information is fairly stated, in all material respects, in relation to the financial statements as a whole.

/s/ Ernst & Young LLP

We have served as the Plan’s auditor since 1998.

Dallas, TX

May 26, 2022

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Comerica Incorporated Preferred Savings Plan

Statements of Net Assets Available for Benefits

(in millions)
December 31	2021		2020
Assets
Investments:
Mutual funds	$	996	$	914
Collective trust funds	724		605
Comerica Incorporated common stock	123		87
Investments, at fair value	1,843		1,606
Separate account guaranteed investment contracts	33		34
Security-backed (synthetic) guaranteed investment contracts	132		138
Investments, at contract value	165		172
Total investments	2,008		1,778
Receivables:
Accrued income receivable	1		1
Notes receivable from participants	22		22
Total receivables	23		23
Net assets available for benefits	$	2,031	$	1,801

See accompanying notes.

2

Comerica Incorporated Preferred Savings Plan

Statements of Changes in Net Assets Available for Benefits

(in millions)
Years Ended December 31	2021		2020
Additions
Dividend and interest income	$	66	$	33
Participant contributions	59		55
Employer contributions	24		24
Interest income on notes receivable from participants	1		1
Total additions	150		113
Deductions
Distributions to participants	157		122
Net appreciation in fair value of investments	237		178
Net increase for the year	230		169
Net assets available for benefits:
Beginning of year	1,801		1,632
End of year	$	2,031	$	1,801

See accompanying notes.

3

Comerica Incorporated Preferred Savings Plan

Notes to Financial Statements

1. Description of the Plan

The Comerica Incorporated Preferred Savings Plan (the Plan) is a 401(k) plan covering all eligible employees of Comerica Incorporated (the Corporation) and its subsidiaries. The Plan is subject to the provisions of the Employee Retirement Income Security Act of 1974 (ERISA). Information about the Plan agreement, participants' investment alternatives and the vesting and benefit provisions is contained in the Summary Plan Description captioned “Comerica Incorporated Preferred Savings 401(k) Plan." Copies of the Summary Plan Description are available in the "Resources" section of BenefitConnect at https://comericabenefits.ehr.com/.

Although the Corporation has not expressed any intent to do so, the Corporation has the right under the Plan to amend or terminate the Plan at any time. In the event the Plan is terminated, all participants' accounts will be fully vested and non-forfeitable.

The following description of the Plan is provided for general information purposes only. Participants should refer to the Plan document and the Summary Plan Description for more complete information.

Eligibility

Effective July 1, 2020, the Plan was amended so that employees are generally eligible to participate in the Plan on the day they first perform service. Prior to July 2020, employees were eligible to participate in the Plan on the first day of the first payroll period commencing on or after the first day of the month coincident with or following six consecutive calendar months of service.

Participant Contributions and Accounts

Participants may make pre-tax contributions and/or Roth contributions to the Plan through payroll deductions. Total contributions may not exceed the lesser of 50 percent of the participant's annual compensation or the Internal Revenue Service (IRS) allowed maximum ($19,500, plus an additional $6,500 for participants age 50 or over, in both 2021 and 2020). Participants direct the investment of their accounts among the investment funds offered by the Plan. Participants may change their investment options at any time. If a participant does not make an investment election upon enrollment, the participant's contributions are invested in the default investment fund designated by the Corporation's Benefits Committee and can be redirected by the participant at any time at their discretion.

Rollover contributions are also accepted from other tax-qualified plans, provided certain specified conditions are met.

The benefit to which a participant is entitled is the benefit that can be provided from the participant's vested account.

Employer Matching Contributions

The Corporation makes a matching contribution on behalf of each eligible participant of 100 percent of the first four percent of qualified earnings contributed by the participant and is invested based on the participant's investment elections. Participants are eligible to receive matching contributions on the first pay date occurring in the calendar month which is immediately following the date the participant completes six consecutive calendar months of service. In the absence of a participant's investment election, the funds are initially invested in the default investment fund designated by the Corporation's Benefit Committee. Employer matching contributions are 100 percent vested at the time they are contributed to a participant's individual account.

Dividend Election

The Plan discontinued the Corporation's common stock as an investment election available to participants for future contributions or reallocations from other investments in 2008. Participants who retained the Corporation's common stock as an investment either have their dividends reinvested within the Plan or may elect to receive the dividends in cash.

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Participant Loans

Participants generally may borrow from their account balances, excluding their Retirement Account Plan balance, an amount not to exceed the lesser of $50,000 or 50 percent of their total contributions, matching contribution and rollover contribution account balances. Participants may have only two loans outstanding at any time. Each loan is required to be repaid within five years or less, or up to 15 years if the loan is for the purchase of a primary residence. The loans are secured by the balance in the participant's account and bear a fixed rate of interest determined at origination (currently the Prime Rate published by Reuters). Principal and interest are paid by the participant through payroll deductions that are credited to the participant's individual account. Participants are charged a fee to initiate each loan as well as a quarterly loan maintenance fee.

Forfeited Accounts

Unallocated employer contributions within the former Retirement Account Plan resulting from employee forfeitures were retained in the Retirement Account Plan in the Stable Value Fund at December 31, 2021 and are used first to restore the accounts of reemployed Participants, then to pay recoverable administrative expenses of the Plan or to reduce the Corporation's contributions.

Employee forfeitures and associated reduction of employer contribution and expenses within the former Retirement Account Plan for the years ended December 31, 2021 and 2020 were insignificant.

Distributions to Participants

Upon separation from service with the Corporation for any reason, a participant whose vested account balance is $5,000 or less may elect to receive either a lump sum or a rollover distribution. A participant whose vested account balance is greater than $5,000 may elect a distribution or remain in the Plan. Distribution options include a rollover distribution, lump sum distribution or monthly, quarterly or annual installments over a fixed period. Distributions are recorded when paid.

In-service withdrawals are permitted upon request of a participant with an attained age of at least 59-1/2 years and in certain other limited circumstances, as defined by the Plan. Hardship withdrawals are allowed for participants incurring an immediate and heavy financial need, as defined by the Plan. Hardship withdrawals are strictly regulated by the IRS and a participant must exhaust all available loan options and available distributions prior to requesting a hardship withdrawal. In-service loans and hardship withdrawals are not permitted on Retirement Account Plan balances.

On March 27, 2020, Congress passed the Coronavirus Aid, Relief, and Economic Security Act (CARES Act), which included several relief provisions available to tax qualified retirement plans and their participants. The provisions of the CARES Act were effective and operationalized immediately, prior to the June 24, 2020 amendment to the Plan document. The Plan adopted certain measures included in the CARES Act which allowed qualified participants to receive coronavirus-related distributions without penalty and delay loan repayments due on or after March 27, 2020 for the remainder of 2020. Additionally, required minimum distributions were temporarily waived for 2020.

Plan Expenses

Administrative and investment expenses incurred in connection with the operation of the Plan are paid by the Corporation and by revenue sharing with the recordkeeper. Certain participant loan fees and transaction expenses are deducted from loan or distribution proceeds, as applicable, or are charged directly to the participant's account. Additionally, the Plan offers fee-based advisory services to participants. Fees for these services are charged directly to the participant's account.

2. Summary of Significant Accounting Policies

Basis of Presentation

The accounting and reporting policies of the Plan conform to U.S. generally accepted accounting principles (GAAP). The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts in the financial statements and accompanying notes. Actual results could differ from those estimates.

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Investment Valuation and Income Recognition

Fair value measurement applies whenever accounting guidance requires or permits assets or liabilities to be measured at fair value. Fair value is defined as the exchange price that would be received to sell an asset or paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction (i.e., not a forced transaction, such as a liquidation or distressed sale) between market participants at the measurement date. Fair value is based on the assumptions market participants would use when pricing an asset or liability. GAAP establishes a three-level fair value hierarchy that prioritizes the information used to estimate fair value. The fair value hierarchy gives the highest priority to quoted prices in active markets and the lowest priority to unobservable data. Fair value measurements are separately disclosed by level within the fair value hierarchy. For assets recorded at fair value, it is the Plan's policy to maximize the use of observable inputs and minimize the use of unobservable inputs when estimating fair value measurements for those items for which there is an active market.

Investment contracts held by a qualified plan are reported at fair value, except for fully benefit-responsive investment contracts, which are reported at contract value. The contract value represents contributions and allocations plus earnings at the crediting rate, less participant withdrawals and administrative expenses.

Securities transactions are recorded on a trade-date basis. Realized gains and losses are reported based on the average cost of securities sold. Dividend income is recorded on the ex-dividend date. Interest income is accounted for on the accrual basis.

Notes Receivable from Participants

Notes receivable from participants represent participant loans that are recorded at their unpaid principal balance plus accrued but unpaid interest. Interest income on notes receivable from participants is recorded when it is earned. Related fees are recorded as transaction fees and expenses and are expensed when they are incurred. No allowance for credit losses was recorded as of December 31, 2021 and 2020. If a participant ceases to make loan repayments and the plan administrator deems the participant loan to be a distribution, the participant loan balance is reduced and a benefit payment is recorded.

3. Fair Value

Fair value measurements are utilized to record fair value adjustments to certain assets and to determine fair value disclosures. Mutual funds, collective trust funds and Comerica Incorporated common stock are recorded at fair value on a recurring basis.

Assets at fair value in the Plan are categorized into a three-level hierarchy based on the markets in which the assets are traded and the reliability of the assumptions used to determine fair value. These levels are:

Level 1	Valuation is based upon quoted prices for identical instruments traded in active markets.
Level 2	Valuation is based upon quoted prices for similar instruments in active markets, quoted prices for identical or similar instruments in markets that are less active, and model-based valuation techniques for which all significant assumptions are observable in the market.
Level 3	Valuation is generated from model-based techniques that use at least one significant assumption not observable in the market. These unobservable assumptions reflect estimates of assumptions that market participants would use in pricing the asset or liability. Valuation techniques include use of option pricing models, discounted cash flow models and similar techniques.

Following is a description of valuation methodologies and key inputs used to measure assets recorded at fair value, including an indication of the level of the fair value hierarchy in which the assets are classified. Transfers of assets between levels of the fair value hierarchy are recognized at the beginning of the reporting period, when applicable.

Mutual funds: Mutual funds are valued at the daily closing price as reported by the fund. Mutual funds held by the Plan are quoted in an active market and are classified in Level 1 of the fair value hierarchy.

Comerica Incorporated common stock: Fair value measurement of Comerica Incorporated common stock is based upon the closing price reported on the New York Stock Exchange and is classified in Level 1 of the fair value hierarchy.

Collective trust funds: Collective trust funds are valued using the net asset value (NAV) provided by the administrator of the fund as a practical expedient to estimate fair value and, therefore, are not categorized into the fair value

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hierarchy. The Stable Value Fund primarily invests in fully benefit-responsive separate account and security-backed guaranteed investment contracts, as well as collective trust funds. The collective trust funds within the Stable Value Fund are also valued at the NAV provided by the administrators of the funds.

The methods described above may produce a fair value that may not be indicative of net realizable value or reflective of future fair values. Furthermore, while the Plan believes its valuation methods are appropriate and consistent with other market participants, the use of different methodologies or assumptions to determine the fair value of certain financial instruments could result in a different fair value measurement at the reporting date.

The following table presents, by level within the fair value hierarchy, the recorded amount of the Plan's assets measured at fair value on a recurring basis. The Plan had no assets classified within Level 2 or Level 3 of the fair value hierarchy at December 31, 2021 and 2020. There were no liabilities measured at fair value at December 31, 2021 and 2020.

(in millions)	Total		Level 1
December 31, 2021
Investments at fair value:
Mutual funds	$	996	$	996
Comerica Incorporated common stock	123		123
Total investments in the fair value hierarchy	1,119		1,119
Collective trust funds, measured at net asset value	724
Total investments at fair value	$	1,843
December 31, 2020
Investments at fair value:
Mutual funds	$	914	$	914
Comerica Incorporated common stock	87		87
Total investments in the fair value hierarchy	1,001		1,001
Collective trust funds, measured at net asset value	605
	$	1,606

The following table summarizes investments for which fair value is measured using the net asset value per share practical expedient as of December 31, 2021 and 2020. There are no participant redemption restrictions for these investments; the redemption notice period is applicable only to the Plan.

(in millions)	December 31,
Collective trust funds:	2021 Fair Value		2020 Fair Value		Unfunded Commitments	Redemption Frequency	Redemption Notice Period
Asset allocation funds	$	385	$	335	None	Daily	None
Large cap fund	335		267		None	Daily	None
Short-term investment fund	4		3		None	Daily	None
Total collective trust funds	$	724	$	605

4. Fully Benefit-Responsive Investment Contracts

    The Plan holds a portfolio of investment contracts which includes a portfolio of separate account and synthetic guaranteed investment contracts. These contracts meet the fully benefit-responsive investment contract criteria and, therefore, are reported at contract value. Contract value is the relevant measure for fully benefit-responsive investment contracts because this is the amount received by participants when they initiate permitted transactions under the terms of the Plan. Contract value represents contributions and allocations made under each contract, plus earnings, less withdrawals. The following represents the disaggregation of contract value between types of investment contracts held by the Plan.

(in millions)	December 31,
Contract Value	2021		2020
Separate account guaranteed investment contracts	$	33	$	34
Synthetic guaranteed investment contracts	132		138
Total	$	165	$	172

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    Separate account and security-backed guaranteed investment contracts are issued by insurance companies or other financial institutions, backed by a portfolio of bonds. The bond portfolio may be structured as a fixed income separate account or collective fund and is either owned by the contract issuer and segregated in a separate account for the benefit of the Plan (separate account guaranteed investment contract) or owned directly by the Plan (synthetic guaranteed investment contract). The issuer guarantees that all qualified participant withdrawals will be at contract value and that the crediting rate applied will not be less than zero percent. Crediting rates are typically reset quarterly to account for the difference between the contract value and the fair value of the underlying portfolio.

    If the Plan defaults in its obligations under the contract (including the issuer’s determination that the agreement constitutes a nonexempt prohibited transaction as defined under ERISA), and such default is not corrected within the time permitted by the contract, then the contract may be terminated by the issuer and the Plan will receive the fair value as of the date of termination. Each contract recognizes certain “events of default” which can invalidate the contracts’ coverage. Among these are investments outside of the range of instruments which are permitted under the investment guidelines contained in the investment contract, fraudulent or other material misrepresentations made to the issuer, changes of control of the investment adviser not approved by the contract issuer, changes in certain key regulatory requirements, or failure of the Plan to be tax qualified.

    The contracts also generally provide for withdrawals associated with certain events which are not in the ordinary course of Plan operations. These withdrawals are paid with a market value adjustment applied to the withdrawal as defined in the investment contract. Each contract issuer specifies the events which may trigger a market value adjustment; however, such events may include, but may not be limited to, the following:

•material amendments to the Plan’s structure or administration;

•complete or partial termination of the Plan, including a merger with another plan;

•the failure of the Plan to qualify for exemption from federal income taxes or any required prohibited transaction exemption under ERISA;

•the redemption of all or a portion of the interests in the Plan at the direction of the plan sponsor, including withdrawals due to the removal of a specifically identifiable group of employees from coverage under the plan (such as a group layoff or early retirement incentive program), the closing or sale of a subsidiary, employing unit, or affiliate, the bankruptcy or insolvency of the plan sponsor, the merger of the plan with another plan, or the plan sponsor’s establishment of another tax qualified defined contribution plan;

•any change in law, regulation, ruling, administrative or judicial position, or accounting requirement, applicable to the Plan;

•changes to competing investment options;

•the delivery of any communication to plan participants designed to influence a participant not to invest in the stable value option.

At this time, the occurrence of any such market value adjustment event is not probable.

5. Transactions With Parties-in-Interest

Certain Plan investments are shares of collective trust funds managed by Comerica Bank (the Bank), a subsidiary of the Corporation. The Bank serves as trustee of the Plan. Transactions involving funds administered by the trustee qualify as exempt party-in-interest transactions. Participants direct how their contributions and matching contributions are invested within the Plan.

The Bank provides the Plan with certain accounting and administrative services for which no fees are charged.

On December 31, 2021 and 2020, the Plan held approximately 1 million and 2 million shares of Comerica Incorporated common stock with fair values of $123 and $87 million, respectively. The Plan recorded dividend income from Comerica Incorporated common stock of $4 million during each of the years ended December 31, 2021 and 2020.

6. Tax Status

The Plan received a determination letter from the IRS dated December 15, 2017, stating that the Plan is qualified under Section 401(a) of the Internal Revenue Code (the Code) and, therefore, the related trust is exempt from taxation. Additionally, the Retirement Account Plan received a determination letter from the IRS dated January 30, 2018, stating that the Retirement

8

Account Plan is qualified under Section 401(a) of the Code and, therefore, the related trust is exempt from taxation. Once qualified, the Plan is required to operate in conformity with the Code to maintain its qualification. The plan administrator has indicated that it will take the necessary steps, if any, to keep the Plan's operations in compliance with the Code.

GAAP requires plan management to evaluate uncertain tax positions taken by the Plan. The financial statement effects of a tax position are recognized when the position is more likely than not, based on the technical merits, to be sustained upon examination by the IRS. The plan administrator has analyzed the tax positions taken by the Plan, and has concluded that as of December 31, 2021, there are no uncertain positions taken or expected to be taken. The Plan has recognized no interest or penalties related to uncertain tax positions. The Plan is subject to routine audits by taxing jurisdictions; however, there are currently no audits for any tax periods in progress.

7. Reconciliation of Financial Statements to Form 5500

The following is a reconciliation of total net assets available for benefits and the increase in net assets available for benefits per the financial statements to amounts reported on Form 5500 for the years ended December 31, 2021 and 2020.

(in millions)
December 31	2021		2020
Net assets available for benefits per financial statements	$	2,031	$	1,801
Adjustment from contract value to fair value for fully benefit-responsive investment contracts	—		7
Net assets per Form 5500	$	2,031	$	1,808
Increase in net assets per financial statements	$	230	$	169
Net adjustment from contract value to fair value for fully benefit-responsive investment contracts	(7)		5
Increase in net assets per Form 5500	$	223	$	174

8. Risks and Uncertainties

Plan participants invest in various investment securities. Investment securities are exposed to various risks such as interest rate, market and credit risks. Due to the level of risk associated with certain investment securities, it is reasonably possible that changes in the values of investment securities will occur in the near term and that such changes could materially affect participants' account balances and the amounts reported in the Statements of Net Assets Available for Benefits.

9

SUPPLEMENTAL SCHEDULE

Comerica Incorporated Preferred Savings Plan

EIN: #38-1998421 Plan #002

Schedule H, Line 4i - Schedule of Assets (Held at End of Year)

December 31, 2021

(dollars in millions)
Identity of Issue, Borrower, Lessor, or Similar Party	Description of Investment Including Maturity Date, Rate of Interest, Collateral, Par, or Maturity Value	Current Value
Mutual Funds
Allspring Global Investments	Allspring Special Mid Cap Value Fund - 546,040 shares	$	27
American Funds	The Growth Fund of America - 2,109,470 shares	157
	Capital World Growth and Income Fund - 1,189,770 shares	76
	EuroPacific Growth Fund - 922,110 shares	60
BlackRock Funds	BlackRock Mid-Cap Growth Equity Fund - 1,679,204 shares	81
Franklin/Templeton Investments	Franklin Rising Dividends Fund - 669,875 shares	65
Gabelli Funds	Gabelli Treasury Money Market Fund - 35,971,266 shares	36
Invesco Funds	Invesco Diversified Dividend Fund -2,908,259 shares	58
	Invesco Developing Markets Fund - 435,517 shares	20
Metropolitan West Funds	Metropolitan West Total Return Bond Plan - 5,603,341 shares	57
Neuberger Berman Funds	Neuberger Berman Genesis Fund - 1,782,468 shares	133
T. Rowe Price Funds	T. Rowe Price Retirement Balanced Fund - 1,380,292 shares	39
Vanguard Funds	Vanguard Mid-Cap Index Fund - 1,377,549 shares	96
	Vanguard Small-Cap Index Fund - 598,753 shares	65
	Vanguard Total Bond Market Index Fund - 2,328,366 shares	26
Total Mutual Funds		996
Collective Trust Funds
Fidelity Investments	Fidelity TD Income Fund - 604,885 shares	10
	Fidelity TD 2005 Fund - 275 units	—
	Fidelity TD 2010 Fund - 318 units	—
	Fidelity TD 2015 Fund - 1,215,466 units	26
	Fidelity TD 2020 Fund - 31,805 units	1
	Fidelity TD 2025 Fund - 4,905,052 units	118
	Fidelity TD 2030 Fund - 145,436 units	4
	Fidelity TD 2035 Fund - 3,871,717 units	105
	Fidelity TD 2040 Fund - 29,840 units	1
	Fidelity TD 2045 Fund - 3,118,089 units	87
	Fidelity TD 2050 Fund - 37,128 units	1
	Fidelity TD 2055 Fund - 745,294 units	21
	Fidelity TD 2060 Fund - 522,812 units	11
	Fidelity TD 2065 Fund - 20,121 units	—
BlackRock	BlackRock Equity Index - 15,244,528 units	335
Wells Fargo/BlackRock	WF/BlackRock Short-Term Investment Fund S - 3,830,067 units	4
Total Collective Trust Funds		724
Comerica Incorporated (a)	Common Stock - 1,410,111 shares	123
Fully Benefit-Responsive Investment Contracts
Metropolitan Life Insurance Company	Separate Account Guaranteed Investment Contract, 1.64%	33
Prudential Insurance Company	Security-Backed (Synthetic) Investment Contract, 1.95%	54
State Street Bank and Trust	Security-Backed (Synthetic) Investment Contract, 2.03%	36
Voya Retirement Insurance and Annuity Company	Security-Backed (Synthetic) Investment Contract, 2.05%	45
Metropolitan Life Insurance Company/Prudential Life Insurance Company/State Street Bank and Trust/Voya Retirement Insurance and Annuity Company	Wrapper contracts	(3)
Total Fully Benefit-Responsive Investment Contracts		165
Total Investments		2,008
Participant Loans (a)	Interest rate range: 4.25% to 11.74%, with various maturity dates	22
Total Investments and Participant Loans		$	2,030

(a)    Party-in-interest.

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SIGNATURE

    Pursuant to the requirements of the Securities Exchange Act of 1934, the trustees (or other persons who administer the Comerica Incorporated Preferred Savings Plan) have duly caused this annual report to be signed on its behalf by the undersigned hereunto duly authorized.

Comerica Incorporated Preferred Savings Plan

By: Comerica Bank, Trustee

/s/ Von E. Hays

Von E. Hays

Senior Vice President - Interim Chief Legal Officer

Dated: May 26, 2022

EXHIBIT INDEX

Exhibit No.	Description
23.1	Consent of Independent Registered Public Accounting Firm (Ernst & Young LLP)

EX-23.1

Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statements listed below pertaining to the Comerica Incorporated Preferred Savings Plan of our report dated May 26, 2022, with respect to the financial statements and schedule of the Comerica Incorporated Preferred Savings Plan included in this Annual Report on Form 11-K for the year ended December 31, 2021:

Registration Statement No. 33-42485 on Form S-8 dated August 29, 1991

Registration Statement No. 33-53220 on Form S-8 dated October 13, 1992

Registration Statement No. 33-53222 on Form S-8 dated October 13, 1992

Registration Statement No. 333-00839 on Form S-8 dated February 9, 1996

Registration Statement No. 333-24567 on Form S-8 dated April 4, 1997

Registration Statement No. 333-50966 on Form S-8 dated November 30, 2000

Registration Statement No. 333-228259 on Form S-8 dated November 7, 2018

/s/ Ernst & Young LLP

Dallas, Texas

May 26, 2022