1© 2022, Comerica Bank. All rights reserved. Comerica Incorporated First Quarter 2022 Financial Review April 20, 2022 2© 2022, Comerica Bank. All rights reserved. Any statements in this presentation that are not historical facts are forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995. Words such as “anticipates,” “believes,” “contemplates,” “feels,” “expects,” “estimates,” “seeks,” “strives,” “plans,” “intends,” “outlook,” “forecast,” “position,” “target,” “mission,” “assume,” “achievable,” “potential,” “strategy,” “goal,” “aspiration,” “opportunity,” “initiative,” “outcome,” “continue,” “remain,” “maintain,” “on track,” “trend,” “objective,” “looks forward,” “projects,” “models” and variations of such words and similar expressions, or future or conditional verbs such as “will,” “would,” “should,” “could,” “might,” “can,” “may” or similar expressions, as they relate to Comerica or its management, are intended to identify forward-looking statements. These forward-looking statements are predicated on the beliefs and assumptions of Comerica's management based on information known to Comerica's management as of the date of this presentation and do not purport to speak as of any other date. Forward-looking statements may include descriptions of plans and objectives of Comerica's management for future or past operations, products or services, and forecasts of Comerica's revenue, earnings or other measures of economic performance, including statements of profitability, business segments and subsidiaries as well as estimates of credit trends and global stability. Such statements reflect the view of Comerica's management as of this date with respect to future events and are subject to risks and uncertainties. Should one or more of these risks materialize or should underlying beliefs or assumptions prove incorrect, Comerica's actual results could differ materially from those discussed. Factors that could cause or contribute to such differences include credit risks (unfavorable developments concerning credit quality; declines or other changes in the businesses or industries of Comerica's customers; and changes in customer behavior); market risks (changes in monetary and fiscal policies; fluctuations in interest rates and their impact on deposit pricing; and transitions away from LIBOR towards new interest rate benchmarks); liquidity risks (Comerica's ability to maintain adequate sources of funding and liquidity; reductions in Comerica's credit rating; and the interdependence of financial service companies); technology risks (cybersecurity risks and heightened legislative and regulatory focus on cybersecurity and data privacy); operational risks (operational, systems or infrastructure failures; reliance on other companies to provide certain key components of business infrastructure; the impact of legal and regulatory proceedings or determinations; losses due to fraud; and controls and procedures failures); compliance risks (changes in regulation or oversight, or changes in Comerica’s status with respect to existing regulations or oversight; the effects of stringent capital requirements; and the impacts of future legislative, administrative or judicial changes to tax regulations); strategic risks (damage to Comerica's reputation; Comerica's ability to utilize technology to efficiently and effectively develop, market and deliver new products and services; competitive product and pricing pressures among financial institutions within Comerica's markets; the implementation of Comerica's strategies and business initiatives; management's ability to maintain and expand customer relationships; management's ability to retain key officers and employees; and any future strategic acquisitions or divestitures); and other general risks (impacts from the COVID-19 global pandemic; changes in general economic, political or industry conditions; the effectiveness of methods of reducing risk exposures; the effects of catastrophic events; changes in accounting standards; the critical nature of Comerica's accounting policies; and the volatility of Comerica’s stock price). Comerica cautions that the foregoing list of factors is not all-inclusive. For discussion of factors that may cause actual results to differ from expectations, please refer to our filings with the Securities and Exchange Commission. In particular, please refer to “Item 1A. Risk Factors” beginning on page 13 of Comerica's Annual Report on Form 10-K for the year ended December 31, 2021. Forward-looking statements speak only as of the date they are made. Comerica does not undertake to update forward-looking statements to reflect facts, circumstances, assumptions or events that occur after the date the forward-looking statements are made. For any forward-looking statements made in this presentation or in any documents, Comerica claims the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Safe Harbor Statement

3© 2022, Comerica Bank. All rights reserved. 1Q22 Review 50% of executive officers are women or racial/ethnic minorities Named 2022 Best Places to Work for LGBTQ+ Equality by the Human Rights Campaign Environmental Sustainability $1.8B in green loans & commitments (3/31/22), up 52% over 3/31/21 Reporting GHG data since 2009 & externally assured since 2013 GHG Goals: reduce scope 1 & 2 emissions 50% by 2025 (already met), 65% by 2030 & 100% by 2050 Member of Partnership for Carbon Accounting Financials Customized, in-house employee education and engagement program on sustainability & climate topics Diversity, Equity & Inclusion Community Committed $95MM to assist low- to moderate-income housing in 2022 through low-income housing tax credits Collected ~1,500 prom dresses for teens served by local nonprofits ~100 Comerica volunteers held a book drive for elementary school students 71.4 79.1 1Q21 1Q22 Deposits1 Transform retail delivery • Align resources to best serve customers • Enhance small business focus Align corporate facilities • Right size & modernize footprint • Increase brand awareness • Focus on community presence Optimize Technology • Accelerate cloud migration • Enhance customer experience • Increase colleague productivity Modernization 11.9 12.4 10.6 12.2 1Q21 1Q22 Loans w/ PPP Loans ex. PPP General Middle Market Loans1 4.3 5.2 1Q21 1Q22 Large Corporate Loans1 1Average; Dollars in billions 2Paycheck Protection Program (PPP) 11% 16% 20% 2 4% 4© 2022, Comerica Bank. All rights reserved. 1Q22 Results Solid loan growth; Seasonality impacted deposits, revenue & expenses 1Includes gains/(losses) related to deferred comp asset returns of ($7MM) 1Q22, $5MM 4Q21, $3MM 1Q21 2Diluted earnings per common share 31Q22 estimated; 1Q21 reflects deferral of CECL standard impact as calculated per regulatory guidance 4Shares repurchased under share repurchase program (millions, except per share data) 1Q22 4Q21 1Q21 Change From 4Q21 1Q21 Average loans $48,273 $47,825 $50,589 $448 $(2,316) Average loans, ex. PPP 47,938 47,136 47,013 802 925 Average deposits 79,103 84,537 71,392 (5,434) 7,711 Net interest income 456 461 443 (5) 13 Provision for credit losses (11) (25) (182) 14 171 Noninterest income1 244 289 270 (45) (26) Noninterest expenses1 473 486 447 (13) 26 Provision for income tax 49 61 98 (12) (49) Net income 189 228 350 (39) (161) Earnings per share2 $1.37 $1.66 $2.43 $(0.29) ($1.06) CET13 9.93% 10.13% 11.02% Key Performance Drivers 1Q22 compared to 4Q21 • Loan growth momentum in many businesses, partly offset by decreases in Mortgage Banker & PPP • Deposits reflect seasonality • MBS & swap portfolios increased to deploy excess liquidity & lock in higher yields • Net interest income benefit from loan & securities growth offset by PPP decrease • Reserves released; Reserve ratio 1.21%; Net charge-offs of 6 bps • Noninterest income impacted by large decreases in warrant income & deferred comp as well as seasonal decline in customer activity • Expense discipline continued; also, included decrease in deferred comp & seasonal increase • Repurchased $35MM shares4

5© 2022, Comerica Bank. All rights reserved. 50.6 49.8 48.1 47.8 48.3 49.3 49.6 3.09 3.25 3.39 3.26 3.22 1Q21 2Q21 3Q21 4Q21 1Q22 4Q21 1Q22 Loans Strong momentum in many businesses, partly offset by Mortgage Banker & PPP 1Q22 compared to 4Q21 1See Average Loans slide in Appendix for more details Loans ($ in billions) Average loans increased $448MM1 + $423MM General Middle Market + $407MM Corporate Banking + $363MM Equity Fund Services + $199MM National Dealer Services + $120MM Environmental Services - $852MM Mortgage Banker Ex. PPP, average loans grew $802MM, or 2% • Ex-PPP, General Middle Market grew 5% • PPP average loans $335MM, $354MM decrease Line Utilization stable at 46% Loan yields decreased 4 bps - 6 bps impact of PPP - 1 bps lower nonaccrual activity + 3 bps higher rates Loan Yields % Average Balances Period-end 6© 2022, Comerica Bank. All rights reserved. Deposits Reflects seasonality & customers using funds in businesses; Up 11% relative to 1Q21 1Q22 compared to 4Q21 1Interest costs on interest-bearing deposits 2At 3/31/22 3Interest incurred on liabilities as a percent of average noninterest–bearing deposits & interest-bearing liabilities 4Source for peer data: S&P Global Market Intelligence 71.4 75.5 79.1 84.5 79.1 82.3 77.6 0.08 0.06 0.06 0.05 0.05 1Q21 2Q21 3Q21 4Q21 1Q22 4Q21 1Q22 Deposits ($ in billions) Deposit Rate1 % Average Balances Period-end Average deposits decreased $5.4B - $2.6B noninterest-bearing - $2.9B interest-bearing Loan to deposit ratio2 64% Total funding costs steady at 6 bps3 7 5 5 5 4 3 3 3 2 1 1 0 C M A B O K F Z IO N C F R R F S N V F IT B K E Y M T B F H N C F G H B A N 4Q21 Deposit Growth Highest Among Peers4 (percentages; 4Q21 vs 3Q21; average)

7© 2022, Comerica Bank. All rights reserved. Securities Portfolio Goal: Reduce asset sensitivity by gradually deploying excess liquidity over time as rates rise 3/31/22 1Outlook as of 4/20/22 2Estimated as of 3/31/22 3On the MBS portfolio Securities Portfolio ($ in billions) 10.3 11.1 12.3 13.3 14.4 14.0 16.0 14.9 15.4 16.0 16.6 17.3 17.0 18.8 1.89 1.82 1.76 1.71 1.74 1Q21 2Q21 3Q21 4Q21 1Q22 4Q21 1Q22 Treasury Securities Mortgage-backed Securities (MBS) Securities Yields % Average portfolio increased $721MM • Period-end increased $1.8B + $3.6B MBS purchases - $740MM MBS payments & $70MM Treasury maturities - $965MM Fair value change • 2Q22: Estimate ~$725MM-$775MM MBS repayments1 • Duration of 4.6 years2 • Extends to 6.1 years under 200bps instantaneous rate increase2 • Net unrealized pre-tax loss of $1,095MM • Net unamortized premium of $50MM3 Average Balances Period-end 69 71 77 1Q21 4Q21 1Q22 Securities Income ($ in millions) Cash / Assets (PE; percentages) 8 15 CMA 2010-2019 Average CMA 1Q22 8© 2022, Comerica Bank. All rights reserved. Net Interest Income Benefit from loan & securities growth more than offset by decline in PPP revenue & 2 fewer days 1Q22 compared to 4Q21 1See Paycheck Protection Program (PPP) slide in appendix for more detail Net Interest Income ($ in millions) 443 465 475 461 456 2.29 2.29 2.23 2.04 2.19 1Q21 2Q21 3Q21 4Q21 1Q22 Net Interest Margin % $461MM 4Q21 2.04% -10MM - 10MM - 6MM - 3MM + 4MM + 5MM Loans PPP1 forgiveness Two fewer days Nonaccrual activity Rates, incl. swaps & floors Balances, ex. PPP - 0.02 - 0.04 - 0.01 + 0.02 + 0.01 + 6MM Securities Balances -- - 1MM Fed Deposits + 0.17 $456MM 1Q22 2.19% 52 bps negative impact on NIM from Fed balances

9© 2022, Comerica Bank. All rights reserved. 325 320 296 269 274 0.64 0.64 0.62 0.55 0.55 - 0.20 0.40 0.60 0.80 1.00 1.20 1.40 1.60 1.80 2.00 1Q21 2Q21 3Q21 4Q21 1Q22 NPA/Loans % Credit Quality Credit metrics remain strong 1Q22 compared to 4Q21 1Criticized loans are consistent with regulatory defined Special Mention, Substandard, & Doubtful categories Nonperforming Assets Remain Low ($ in millions) Criticized Loans1 Well Below Historic Average ($ in millions) 807 683 639 618 599 1.59 1.36 1.33 1.26 1.21 - 1.00 2.00 3.00 4.00 5.00 6.00 1Q21 2Q21 3Q21 4Q21 1Q22 ACL/Loans % Reserve Continued to Decline Gradually ($ in millions) • $8MM of net charge-offs, or 6 bps • $18MM gross charge-offs ($20MM 4Q21) • $6MM legacy Energy Services • $10MM recoveries ($24MM 4Q21) • $5MM increase in nonperforming assets + $22MM retail (COVID-19-related deferrals ended 12/31/21) - $17MM commercial 2,581 2,176 1,818 1,573 1,647 5.1 4.3 3.8 3.2 3.3 - 2.00 4.00 6.00 8.00 10.00 12.00 1Q21 2Q21 3Q21 4Q21 1Q22 Criticized/Loans % 10© 2022, Comerica Bank. All rights reserved. Noninterest Income Large decrease in warrant income & deferred comp as well as seasonal decline in customer activity 1Q22 compared to 4Q21 1Gains/(losses) related to deferred comp asset returns of $3MM 1Q21, $6MM 2Q21, -0- 3Q21, $5MM 4Q21, ($7MM) 1Q22 (offset in noninterest expense) 2 Credit Valuation Adjustment (CVA) $10MM 1Q21, $1MM 2Q21, $3MM 3Q21, $4MM 4Q21, ($2MM) 1Q22 Noninterest Income1 ($ in millions) 270 284 280 289 244 1Q21 2Q21 3Q21 4Q21 1Q22 Decreased $45MM - $14MM Warrant-related Income (other noninterest income) - $12MM Deferred Comp (other noninterest income; offset in noninterest expense) - $ 6MM Commercial Lending (syndication/seasonal) - $ 5MM Derivative Income2 (CVA -$2MM, -$6MM change) - $ 2MM Service Charges on Deposits (seasonal) - $ 2MM Fiduciary - $ 2MM Card (seasonal) + $ 2MM Bank Owned Life Insurance (BOLI)

11© 2022, Comerica Bank. All rights reserved. 447 463 465 486 473 1Q21 2Q21 3Q21 4Q21 1Q22 Noninterest Expenses1 ($ in millions) Noninterest Expenses Continue to maintain our expense discipline as we position for future growth 1Q22 compared to 4Q21 1Gains/(losses) related to deferred comp plan of $3MM 1Q21, $6MM 2Q21, -0- 3Q21, $5MM 4Q21, ($7MM) 1Q22 (offset in noninterest income) Decreased $13MM - $3MM Salaries & benefits - $12MM Deferred comp1 (offset in noninterest income) - $10MM Staff insurance (mostly seasonal) - $ 8MM Performance-based incentives + $23MM Annual stock comp + $ 7MM Payroll taxes (seasonal) - $6MM Occupancy (seasonal) - $4MM Legal Fees (other noninterest expenses) - $4MM Outside Processing (seasonal) - $3MM Advertising (seasonal) + $8MM Operational Losses (other noninterest expenses) + $3MM FDIC expenseNew modernization initiatives totaling $6MM, including: • Consulting • Severance • Asset impairment 12© 2022, Comerica Bank. All rights reserved. 140 131 3/31/2021 3/31/2022 Capital Management Continue to focus on CET1 target of ~10%1 3/31/22 1Outlook as of 4/20/22 21Q22 estimated 3Shares repurchased under share repurchase program 4See Holding Company Debt Rating slide 5Source for peer data: S&P Global Market Intelligence 10.13% 9.93% 7.0% 4Q21 1Q22 CET12 Tier 12 10.70% 10.47% 8.5% 4Q21 1Q22 Capital management priorities • Support customers; drive growth • Provide attractive dividend • $0.68/share or $89MM • Return excess capital to shareholders • $35MM or 377,849 shares repurchased3 • Maintain strong debt ratings4 • CET1 target of ~10%1 Regulatory Minimum + Capital Conservation Buffer (CCB) Attractive Dividend Yield5 (percentages; 3/31/22) 3.01 2.85 1.37 CMA Peer Avg. S&P 500 Shares Outstanding (millions) -6%

13© 2022, Comerica Bank. All rights reserved. ~180 ~310 ~85 ~125 ~130 160 ~170 25 bp Shock 50% Deposit Beta $5B DDA Runoff 1Q22 Standard Model 50 bps Shock 10% Deposit Beta 200 bps increase Interest Rate Sensitivity Positioned for a rising rate environment 0.1SSS Loan Balances Modest increase Loan Spreads Held at current levels Deposit Balances Moderate decrease Deposit Beta ~30% Securities Portfolio Held flat at current level Hedging (Swaps) No additions modeled Standard Model Assumptions1 100 bps (50 bps avg) linear, non-parallel rise Sensitivity Analysis Estimated Increase in Net Interest Income Over 12 months Additional Scenarios are Relative to 1Q22 Standard Model ($ in millions) 3/31/22 1For methodology see Company’s Form 10-K, as filed with the SEC. Estimates are based on simulation modeling analysis 2Outlook as of 4/20/22 3Received fixed/pay floating; swap positions & rates as of 3/31/22 & historical results for 12/31/21 & 3/31/22; maturities extend through 3Q28 22.6 22.8 15.3 16.1 15.5 15.9 14.2 12.8 11.9 10.3 13.7 14.5 14.2 14.4 14.5 14.5 25.6 29.8 30.0 30.1 28.6 27.3 26.4 4Q21 1Q22 2Q22 3Q22 4Q22 1Q23 2Q23 3Q23 4Q23 31-Dec Added in 1Q22 Projected Swap Benefit $11.15B total swaps, includes $3.5B added in 1Q223; Excludes future rate increases ($ in millions; as of 3/31/22) Management Outlook for Net Interest Income2 • >13% increase for FY22, relative to FY21 (including PPP) • ~15% increase for 2Q22, relative to 1Q22 (including PPP) • Assumptions • Rate increases March (25 bps) & May (50 bps) • Loan & deposit as outlined on slide 14 • Swaps & securities at 3/31/22 14© 2022, Comerica Bank. All rights reserved. Management Outlook Assumes economy remains strong Outlook as of 4/20/22 FY22 vs FY21 Average loans + Mid single-digit growth, ex-PPP; driven by nearly every business, partly offset by decreases in Mortgage Banker & National Dealer; Including PPP, loans stable • Relative to 1Q22, increase 1-2% every quarter, with growth across most businesses Average deposits = Stable • Relative to 1Q22, modest decline remainder of the year Net interest income + See slide 13; Additional hedging & rate increases could provide further upside Credit Quality • Net charge-offs lower end of normal range; Nonaccrual & criticized loans remain low Noninterest income - Decline in card, derivatives (FY21 CVA $18MM), warrants, deferred comp (FY21 $15MM), partly offset by growth in several customer-related categories, e.g., fiduciary, deposit service charges • Relative to 1Q22, deferred comp (1Q22 -$7MM) & CVA (-$2MM) not expected to repeat; stronger customer activity as year progresses Noninterest expenses + Low single-digit growth driven by comp, technology investments, T&E & insurance • Relative to 1Q22, relatively stable; salary & benefits modestly lower; Higher advertising & technology expenses mostly offset by lower operating losses Tax • FY tax rate 22-23%, excluding discrete items Capital • Target CET1 of ~10%

15© 2022, Comerica Bank. All rights reserved. Key Strengths Poised to support growth Relationship Focused • Expertise in specialty businesses • Long-tenured, experienced team Diversified • Footprint includes faster growth markets • Balanced exposure to a wide variety of industries Revenue Opportunities • High-caliber, robust Cash Management suite, including Card programs • Collaboration between 3 revenue divisions Credit Discipline • Consistent, conservative underwriting standards • Superior credit performance through last recession Expense Control • Continuous improvement culture • Invest for the future • Leveraging technology to drive productivity & growth Uniquely Positioned • Nimble asset size • Weighted to commercial banking • Strong deposit base Appendix

17© 2022, Comerica Bank. All rights reserved. Quarterly Average Loans $ in billions Totals shown above may not foot due to rounding 1Other Markets includes Florida, Arizona, the International Finance Division and businesses that have a significant presence outside of the three primary geographic markets 2Fixed rate loans include $5.7B receive fixed/pay floating (30-day) LIBOR , BSBY & SOFR interest rate swaps Business Line 1Q22 4Q21 1Q21 Middle Market General $12.4 $11.9 $11.9 Energy 1.3 1.3 1.5 National Dealer Services 4.1 3.9 5.3 Entertainment 1.1 1.2 0.8 Tech. & Life Sciences 0.9 0.8 1.0 Equity Fund Services 3.2 2.8 2.6 Environmental Services 2.0 1.8 1.5 Total Middle Market $24.9 $23.9 $24.7 Corporate Banking US Banking 3.7 3.3 3.0 International 1.5 1.5 1.3 Commercial Real Estate 6.6 6.6 6.7 Mortgage Banker Finance 1.6 2.4 3.2 Business Banking 3.3 3.3 4.1 Commercial Bank $41.5 $41.0 $42.9 Retail Bank $2.0 $2.1 $2.6 Wealth Management $4.7 $4.8 $5.1 TOTAL $48.3 $47.8 $50.6 By Market 1Q22 4Q21 1Q21 Michigan $11.7 $11.4 $12.3 California 17.2 17.1 17.9 Texas 9.8 9.5 10.1 Other Markets1 9.7 9.8 10.2 TOTAL $48.3 $47.8 $50.6 Fixed Rate 22% 30-Day Rate 61% 60-Day+ Rate 5% Prime-based 12% 2 $49.6B Loan Portfolio (1Q22 Period-end) Includes $15.8B with average floors at 0.59% 18© 2022, Comerica Bank. All rights reserved. Quarterly Average Deposits $ in billions Totals shown above may not foot due to rounding 1Finance/Other includes items not directly associated with the geographic markets or the three major business segments 2Other Markets includes Florida, Arizona, the International Finance Division and businesses that have a significant presence outside of the three primary geographic markets Business Line 1Q22 4Q21 1Q21 Middle Market General $22.2 $24.7 $20.4 Energy 0.6 0.6 0.6 National Dealer Services 1.9 2.1 0.5 Entertainment 0.3 0.2 0.2 Tech. & Life Sciences 7.3 8.3 6.2 Equity Fund Services 1.2 1.5 0.9 Environmental Services 0.3 0.4 0.2 Total Middle Market $33.9 $37.8 $28.9 Corporate Banking US Banking 2.7 3.4 3.1 International 2.3 2.2 2.3 Commercial Real Estate 2.2 2.1 1.9 Mortgage Banker Finance 0.6 0.7 0.9 Business Banking 4.4 4.6 4.1 Commercial Bank $46.0 $50.8 $41.1 Retail Bank $26.9 $26.7 $24.3 Wealth Management $5.3 $5.7 $4.8 Finance / Other1 $0.9 $1.3 $1.1 TOTAL $79.1 $84.5 $71.4 By Market 1Q22 4Q21 1Q21 Michigan $28.1 $28.5 $25.7 California 23.5 26.5 19.9 Texas 11.8 12.0 10.8 Other Markets2 14.7 16.2 14.0 Finance / Other1 0.9 1.3 1.1 TOTAL $79.1 $84.5 $71.4 Commercial Noninterest- bearing 45% Commercial Interest- bearing 19% Retail Interest- bearing 26% Retail Noninterest- bearing 10% Total $79.1B Beneficial Deposit Mix (1Q22 Average)

19© 2022, Comerica Bank. All rights reserved. Paycheck Protection Program (PPP) Supporting our customers 3/31/22 1Program to Date through 3/31/22 2PPP income is reflected in net interest income 3,576 3,459 1,659 689 335 459 233 1Q21 2Q21 3Q21 4Q21 1Q22 4Q21 1Q22 PPP Loans ($ in millions) Average Balances Period-end PPP Loans Since Inception1 • $4.9B funded / >20,000 applications processed • $4.6B repaid, mostly forgiven • FY20: PPP income $ 63MM ($2.5B average loans) • FY21: PPP income $111MM ($2.3B average loans) PPP Income2 ($ in millions) 30.6 31.6 33.6 15.6 5.4 0.0 5.0 10.0 15.0 20.0 25.0 30.0 35.0 40.0 1Q21 2Q21 3Q21 4Q21 1Q22 20© 2022, Comerica Bank. All rights reserved. Energy Business Line Credit quality continued to improve 3/31/22 1Criticized loans are consistent with regulatory defined Special Mention, Substandard, & Doubtful categories 2Net credit-related charge-offs (recoveries) Period-end Loans ($ in millions) 1,077 1,025 1,008 971 1,046 270 277 244 212 203 19 18 25 21 14 1,366 1,320 1,277 1,204 1,263 1Q21 2Q21 3Q21 4Q21 1Q22 Services Midstream Exploration & Production • Exposure $3.1B / 41% utilization • $6MM NCO related to legacy Energy Services • Decreases in Criticized & Nonaccrual • Spring redeterminations 22% completed • Most borrowing bases are increasing • Hedged 50% or more of production • At least one year: 77% of customers • At least two years: 44% of customers • Focus on larger, sophisticated E&P and Midstream companies • E&P: 53% Oil, 21% Gas, 26% Oil/Gas ($ in millions; Period-end) 1Q22 4Q21 1Q21 Total PE loans $1,263 $1,204 $1,366 % of total CMA 2.5% 2.4% 2.7% Criticized1 $51 $58 $389 Ratio 4.0% 4.8% 28.5% Nonaccrual $12 $14 $93 Ratio 1.0% 1.2% 6.8% Net charge-offs (recoveries)2 $6 $(19) $(1)

21© 2022, Comerica Bank. All rights reserved. Mortgage Banker Finance 55+ years experience with reputation for consistent, reliable approach 3/31/22 1Source: Mortgage Bankers Association (MBA) Mortgage Finance Forecast as of 3/21/22; 4Q21 actual • Provide warehouse financing: bridge from residential mortgage origination to sale to end market • Extensive backroom provides collateral monitoring & customer service • Focus on full banking relationships • As of 1Q22: • Comerica: 71% purchase • Industry: 55% purchase1 • Strong credit quality • No charge-offs since 2010 • Period-end loans: $2.2B (4Q21 $3.0B) Average Loans ($ in millions) 1 ,4 35 1 ,7 84 1 ,9 61 1 ,6 77 1 ,3 35 2 ,0 44 2 ,5 21 2 ,6 81 2 ,0 42 3 ,2 78 3 ,5 85 3 ,7 91 3 ,2 11 2 ,9 24 2 ,7 57 2 ,4 50 1 ,5 97 0 500 1000 1500 2000 1 Q 1 8 2 Q 1 8 3 Q 1 8 4 Q 1 8 1 Q 1 9 2 Q 1 9 3 Q 1 9 4 Q 1 9 1 Q 2 0 2 Q 2 0 3 Q 2 0 4 Q 2 0 1 Q 2 1 2 Q 2 1 3 Q 2 1 4 Q 2 1 1 Q 2 2 Actual MBA Mortgage Origination Volumes1 MBA Mortgage Originations Forecast1 ($ in billions) 893 689 710 625 610 4Q21 1Q22 2Q22 3Q22 4Q22 Purchase Refinance 22© 2022, Comerica Bank. All rights reserved. National Dealer Services 75+ years of floor plan lending 3/31/22 1Other includes obligations where a primary franchise is indeterminable (rental car and leasing companies, heavy truck, recreational vehicles, and non-floor plan loans) Franchise Distribution (Based on period-end loan outstandings) Toyota/Lexus 15% Honda/Acura 8% Ford 9% GM 7% Fiat/Chrysler 9% Mercedes 6% Nissan/ Infiniti 3% Other European 14% Other Asian 12% Other 17% • Top tier strategy • National scope with customers in 42 states • Focus on “Mega Dealer” (five or more dealerships in group) • Strong credit quality; Robust monitoring of company inventory & performance • Floor Plan remained low due to supply chain constraints 4 .1 4 .2 3 .8 4 .0 4 .4 4 .5 4 .1 4 .0 3 .6 2 .8 1 .9 2 .2 2 .0 1 .2 0 .6 0 .6 0 .6 7 .3 7 .4 7 .0 7 .4 7 .8 7 .9 7 .5 7 .3 6 .8 6 .2 5 .3 5 .5 5 .3 4 .4 3 .8 3 .9 4 .1 1 Q 1 8 2 Q 1 8 3 Q 1 8 4 Q 1 8 1 Q 1 9 2 Q 1 9 3 Q 1 9 4 Q 1 9 1 Q 2 0 2 Q 2 0 3 Q 2 0 4 Q 2 0 1 Q 2 1 2 Q 2 1 3 Q 2 1 4 Q 2 1 1 Q 2 2 Floor Plan Average Loans ($ in billions) Total $4.3B 1

23© 2022, Comerica Bank. All rights reserved. 3 2 2 1 1 100 99 99 28 26 1.5% 1.4% 1.5% 0.4% 0.4% 0.0% 0.5% 1.0% 1.5% 2.0% 2.5% 3.0% 1Q21 2Q21 3Q21 4Q21 1Q22 NAL Criticized % Criticized/Loans 5 ,2 59 5 ,3 49 5 ,3 16 5 ,2 23 5 ,3 15 5 ,5 17 5 ,6 58 5 ,8 83 6 ,2 10 6 ,6 59 6 ,6 83 6 ,6 99 6 ,6 90 6 ,8 83 6 ,7 97 6 ,5 79 6 ,6 04 1 Q 1 8 2 Q 1 8 3 Q 1 8 4 Q 1 8 1 Q 1 9 2 Q 1 9 3 Q 1 9 4 Q 1 9 1 Q 2 0 2 Q 2 0 3 Q 2 0 4 Q 2 0 1 Q 2 1 2 Q 2 1 3 Q 2 1 4 Q 2 1 1 Q 2 2 Multifamily 45% Industrial / Storage 26% Retail 9% Office 9% Single Family 2% Other 2% Land Carry 4% Multi use 3% Commercial Real Estate Business Line Very strong credit quality 3/31/22 1Excludes CRE business line loans not secured by real estate 2Period-end loans 3Criticized loans are consistent with regulatory defined Special Mention, Substandard & Doubtful categories Primarily Lower Risk Multifamily1 (1Q22 period-end) Total $5.6B • Long history of working with well-established, proven developers • >90% of new commitments from existing customers • Substantial upfront equity required • 40% of Industrial/ Storage & 38% of Multifamily are construction loans1,2 • Majority high growth markets within footprint: • 42% California • 24% Texas Credit Quality No significant net charge-offs since 2014 ($ in millions) 3 Total CRE Business Line Average Loans ($ in millions) 24© 2022, Comerica Bank. All rights reserved. 6,216 7,093 7,448 8,290 7,341 3,000 4,000 5,000 6,000 7,000 8,000 9,000 1Q21 2Q21 3Q21 4Q21 1Q22 1,048 949 843 841 856 1Q21 2Q21 3Q21 4Q21 1Q22 Technology & Life Sciences ~30 years of deep expertise & strong relationships with top-tier investors 3/31/22 1Includes estimated distribution of PPP loans Average Loans ($ in millions) • Manage concentration to numerous verticals to ensure widely diversified portfolio • Closely monitor cash balances & maintain robust backroom operation • 10 offices throughout US & Canada Average Deposits ($ in millions) Growth 50% Early Stage 17% Late Stage 33% Customer Segment Overview1 (approximate; 1Q22 period-end loans) Total $0.8B

25© 2022, Comerica Bank. All rights reserved. Equity Fund Services Strong relationships with top-tier venture capital & private equity firms 3/31/22 • Customized solutions for venture capital & private equity firms • Credit Facilities • Treasury Management • Capital Markets, including syndication • Customers in the US & Canada • Drives connectivity with other teams • Energy • Middle Market • TLS • Environmental Services • Private Banking • Commercial Real Estate • Strong credit profile • No charge-offs • No criticized loans Average Loans ($ in millions) 2,627 2,696 2,951 2,846 3,209 1Q21 2Q21 3Q21 4Q21 1Q22 26© 2022, Comerica Bank. All rights reserved. Environmental Services Department 15+ years experience; Specialized industry, committed to growth 3/31/22 • Dedicated relationship managers advise & guide customers on profitably growing their business by providing banking solutions • Waste management firms which collect, transport, treat, recycle, process &/or dispose of waste • Recycling & renewable energy companies • Insight & expertise with • Transfer stations, disposal & recycling facilities • Commercial & residential waste collection • Landfill gas to energy; waste to energy • Acquisitions • Growth capital expenditures • Focus on middle market-sized companies with full banking relationships • Historically strong credit quality 1,476 1,683 1,844 1,834 1,954 1Q21 2Q21 3Q21 4Q21 1Q22 Average Loans ($ in millions)

27© 2022, Comerica Bank. All rights reserved. Holding Company Debt Rating As of 4/13/22 Source: S&P Global Market Intelligence; Debt Ratings are not a recommendation to buy, sell, or hold securities; Zions Bancorporation ratings are for the bank Senior Unsecured/Long-Term Issuer Rating Moody’s S&P Fitch Cullen Frost A3 A- - M&T Bank A3 BBB+ A BOK Financial A3 BBB+ A Comerica A3 BBB+ A- Fifth Third Baa1 BBB+ A- Huntington Baa1 BBB+ A- KeyCorp Baa1 BBB+ A- Regions Financial Baa2 BBB+ BBB+ Zions Bancorporation Baa1 BBB+ BBB+ First Horizon National Corp Baa3 BBB- BBB Citizens Financial Group - BBB+ BBB+ Synovus Financial - BBB- BBB