Comerica Incorporated Fourth Quarter 2015Financial Review January 19, 2016 2 Safe Harbor Statement Any statements in this presentation that are not historical facts are forward-looking statements as defined in the Private Securities LitigationReform Act of 1995. Words such as “anticipates,” “believes,” “contemplates,” “feels,” “expects,” “estimates,” “seeks,” “strives,” “plans,” “intends,”“outlook,” “forecast,” “position,” “target,” “mission,” “assume,” “achievable,” “potential,” “strategy,” “goal,” “aspiration,” “opportunity,” “initiative,”“outcome,” “continue,” “remain,” “maintain,” “on course,” “trend,” “objective,” “looks forward,” “projects,” “models” and variations of such words andsimilar expressions, or future or conditional verbs such as “will,” “would,” “should,” “could,” “might,” “can,” “may” or similar expressions, as theyrelate to Comerica or its management, are intended to identify forward-looking statements. These forward-looking statements are predicated onthe beliefs and assumptions of Comerica's management based on information known to Comerica's management as of the date of thispresentation and do not purport to speak as of any other date. Forward-looking statements may include descriptions of plans and objectives ofComerica's management for future or past operations, products or services, and forecasts of Comerica's revenue, earnings or other measures ofeconomic performance, including statements of profitability, business segments and subsidiaries, estimates of credit trends and global stability.Such statements reflect the view of Comerica's management as of this date with respect to future events and are subject to risks anduncertainties. Should one or more of these risks materialize or should underlying beliefs or assumptions prove incorrect, Comerica's actual resultscould differ materially from those discussed. Factors that could cause or contribute to such differences are changes in general economic, politicalor industry conditions; changes in monetary and fiscal policies, including changes in interest rates; changes in regulation or oversight; Comerica'sability to maintain adequate sources of funding and liquidity; the effects of more stringent capital or liquidity requirements; declines or otherchanges in the businesses or industries of Comerica's customers, including the energy industry; operational difficulties, failure of technologyinfrastructure or information security incidents; reliance on other companies to provide certain key components of business infrastructure; factorsimpacting noninterest expenses which are beyond Comerica's control; changes in the financial markets, including fluctuations in interest rates andtheir impact on deposit pricing; changes in Comerica's credit rating; unfavorable developments concerning credit quality; the interdependence offinancial service companies; the implementation of Comerica's strategies and business initiatives; Comerica's ability to utilize technology toefficiently and effectively develop, market and deliver new products and services; competitive product and pricing pressures among financialinstitutions within Comerica's markets; changes in customer behavior; any future strategic acquisitions or divestitures; management's ability tomaintain and expand customer relationships; management's ability to retain key officers and employees; the impact of legal and regulatoryproceedings or determinations; the effectiveness of methods of reducing risk exposures; the effects of terrorist activities and other hostilities; theeffects of catastrophic events including, but not limited to, hurricanes, tornadoes, earthquakes, fires, droughts and floods; changes in accountingstandards and the critical nature of Comerica's accounting policies. Comerica cautions that the foregoing list of factors is not exclusive. Fordiscussion of factors that may cause actual results to differ from expectations, please refer to our filings with the Securities and ExchangeCommission. In particular, please refer to “Item 1A. Risk Factors” beginning on page 12 of Comerica's Annual Report on Form 10-K for the yearended December 31, 2014. Forward-looking statements speak only as of the date they are made. Comerica does not undertake to updateforward-looking statements to reflect facts, circumstances, assumptions or events that occur after the date the forward-looking statements aremade. For any forward-looking statements made in this presentation or in any documents, Comerica claims the protection of the safe harbor forforward-looking statements contained in the Private Securities Litigation Reform Act of 1995.

3 Financial Summary $ in millions, except per share data ● n/a – not applicable ● 1Including $45MM,$48MM & $181MM impact of accountingpresentation of a card program in 4Q15, 3Q15 & 2015, respectively. ● 2Basel III capital rules (standardized approach) became effective for Comerica on 1/1/15. The ratio reflects transitional treatment for certain regulatory deductions and adjustments. Capital ratios for prior periods are based on Basel I rules. ● 3See slide 30 for a reconciliation of non-GAAP financial measures. ● 4Estimated 4Q15 3Q15 2015 2014 Diluted income per common share $0.71 $0.74 $2.92 $3.16 Net interest income $433 $422 $1,689 $1,655 Provision for credit losses 35 26 122 27 Noninterest income1 270 264 1,050 868 Noninterest expenses1 489 461 1,845 1,626 Net income 130 136 535 593 Total average loans $48,548 $48,972 $48,628 $46,588 Total average deposits 59,736 59,140 58,326 54,784 Basel III common equity Tier 1 capital ratio3 10.53%4 10.51% 10.53%4 n/a Tier 1 common capital ratio2,3 n/a n/a n/a 10.50% Average diluted shares (millions) 179 181 181 185 4 Full-Year 2015 Results $ in millions, except per share data ● n/m – not meaningful ● 2015 compared to 2014 ● 1Excludes $181MM impact of accounting presentation of a card program in 2015. The Corporation believes this information will assist investors, regulators,management and others in comparing results to prior quarters. ● 2EPS based on diluted income per share. ● 3See slide 30 for a reconciliation of non-GAAP financial measures. ● 4FY15 repurchases under the equity repurchase program. FY15 From FY14Chg $ Chg %Total average loans $48,628 $2,040 4% Total average deposits 58,326 3,542 6% Net interest income 1,689 34 2% Loan accretion 7 (27) n/m Provision for credit losses 122 95 n/m Net charge-offs 75 50 n/m Noninterest income 1,050 182 21% Excl. impact of acct. presentation1 869 1 - Noninterest expenses 1,845 219 13% Excl. impact of acct. presentation1 1,664 38 2% Net income 535 (58) (10)% Earnings per share (EPS)2 2.92 (0.24) (8)% Tangible Book Value Per Share3 39.41 1.69 4% Equity repurchases4 5.1MM shares & 500,000 warrants or $242MM Key YoY Performance Drivers Broad-based loan & deposit growth Net interest income increased with loan growth partially offset by accretion decline Provision increased from historically low level; Net charge-offs remain low at 15 bps Noninterest income stable1 with increases in card fees, offset by decreases in derivative income & letters of credit fees Expense increase1 due to rise in technology, regulatory, outside processing & pension partially offset by litigation reserve release Equity repurchases4 combined with dividends, returned $389MM or 73% to shareholders

5 Fourth Quarter 2015 Results $ in millions, except per share data ● 4Q15 compared to 3Q15 ● 1Including the $45MM & $48MM impact of accounting presentation of a card program in 4Q15 & 3Q15, respectively. ● 2EPS based on diluted income per share. ● 3See slide 30 for a reconciliation of non-GAAP financial measures. ● 44Q15 repurchases under the equity repurchase program. 4Q15 Change From3Q15 4Q14Total average loans $48,548 $(424) $1,187 Total average deposits 59,736 596 1,976 Net interest income 433 11 18 Provision for credit losses 35 9 33 Net charge-offs 26 3 25 Noninterest income1 270 6 45 Noninterest expenses1 489 28 70 Net income 130 (6) (19) Earnings per share (EPS)2 0.71 (0.03) (0.09) Tangible Book Value Per Share3 39.41 0.05 1.69 Equity repurchases4 1.5MM shares or $65MM Key QoQ Performance DriversLoans relatively stable, as expected Deposit growth continues Net interest income up 3% with higher nonaccrual interest & rise in rates Provision reflected modest reserve build; Net charge-offs remain below normal at 21 bps Noninterest income up 2% with higher commercial lending fees Expense increase, as expected, due to technology & regulatory costs & certain items that benefitted 3Q15 Tax rate lower with termination of leveraged leases Equity repurchases4 increased $6MM, combined with dividends, returned $102MM or 79% to shareholders 7.8 10.0 10.2 10.8 10.9 2011 2012 2013 2014 2015 6 Diverse Footprint Drives GrowthRobust growth in California $ in billions ● 1Includes Sterling Bancshares from July 2011 acquisition. 7.7 9.6 10.0 11.0 11.2 2011 2012 2013 2014 2015 Average Loans Average Deposits 11.8 12.7 14.0 15.4 16.6 2011 2012 2013 2014 2015 Average Loans 12.7 14.6 14.7 16.1 17.8 2011 2012 2013 2014 2015 Average Deposits 13.9 13.6 13.5 13.3 13.2 2011 2012 2013 2014 2015 Average Loans 18.5 19.6 20.3 21.0 21.9 2011 2012 2013 2014 2015 Average Deposits CAGR+10% CAGR+9% CAGR+9% CAGR+9% CAGR+4% CAGR-1% +2% +1% +8% +10% +4% -1% 1 1

7 Average Loans Relatively Stable, As ExpectedYields increase; Maintaining pricing and structure discipline 4Q15 compared to 3Q15 ● 1Utilization of commercial commitments as a percentage of total commercial commitments at period-end. Total Loans($ in billions) 47.4 48.2 48.8 49.0 48.5 48.9 49.1 3.22 3.19 3.20 3.17 3.24 4Q14 1Q15 2Q15 3Q15 4Q15 3Q15 4Q15 Loan Yields Average Balances Period-end Average loans decreased $424MM - Mortgage Banker Finance- General Middle Market - Energy+ Commercial Real Estate+ National Dealer Services Period-end loans increased $167MM  Commitments down ~1% to $56.1B  Line utilization1 stable at 50%  Loan pipeline remains strongLoan yields +7 bps  Increase in nonaccrual interest received  Short-term rates increased ~25 bps as of quarter end 8 Deposit Growth ContinuesDeposit pricing stable 4Q15 compared to 3Q15 ● 1Interest costs on interest-bearing deposits ● 2At 12/31/15 Average Balances Period-end Strong Deposit Base($ in billions) 57.8 57.0 57.4 59.1 59.7 58.8 59.9 0.15 0.15 0.14 0.14 0.14 4Q14 1Q15 2Q15 3Q15 4Q15 3Q15 4Q15 Deposit Rates 1 Total average deposits increased $596MM or 1% + Corporate Banking+ Private Banking- Technology and Life Sciences- General Middle Market  Noninterest-bearing deposits increased $1.0B to $29.6B  Interest-bearing deposits decreased $408MM to $30.1B  About 2/3 of total deposits are commercial Loan to Deposit Ratio2 of 82%

9 At 12/31/15 ● 1Estimated as of 12/31/15. Excludes auction rate securities (ARS). ● 2Net unrealized pre-tax gain on the available-for-sale (AFS) portfolio. ● 3Net unamortized premium on the MBS portfolio. Securities portfolio increased to $12.5B  During 4Q15, invested $1.9B of excess reserves into higher yielding, high quality securities while maintaining asset sensitive position  Duration of 3.7 years1 • Extends to 4.4 years under a 200 bps instantaneous rate increase1  Net unrealized pre-tax gain of $28MM2  Net unamortized premium of $37MM3  GNMA ~40% of MBS portfolio 9.0 9.1 9.1 9.1 9.2 9.4 9.5 9.4 9.9 9.9 10.2 10.9 10.6 12.5 2.19 2.16 2.13 2.11 2.11 4Q14 1Q15 2Q15 3Q15 4Q15 3Q15 4Q15 Treasury Securities & OtherMortgage-backed Securities (MBS)Securities Yields Securities Portfolio($ in billions) Average Balances Period-end Increased Securities PortfolioYield stable Net Interest Income($ in millions) 10 Net Interest Income Increased 3%NIM expands 4 bps 4Q15 compared to 3Q15 415 413 421 422 433 2.57 2.64 2.65 2.54 2.58 4Q14 1Q15 2Q15 3Q15 4Q15 NIM Net Interest Income and Rate NIM $422MM 3Q15 2.54% +5MM Loan impacts:+ $6MM nonaccrual interest+ $3MM higher yields- $3MM lower loan balances- $1MM lower accretion +0.05 +2MM Higher securities balance +2MM Lower funding costs +2MM Short-term investments, including higher Fed balances -0.01 $433MM 4Q15 2.58%

1 8 18 23 26 1 7 15 19 21 4Q14 1Q15 2Q15 3Q15 4Q15 NCO Ratio 11 Credit Quality Remains SolidContinued to build reserve for energy loans At 12/31/15 ● 1“Normal” estimates are based on internal historical analysis & management judgement.● 2Criticized loans are consistent with regulatory defined Special Mention, Substandard, Doubtful & Loss loan classifications. ● 3This information includes all loans related to energy at 12/31/15, ~$3.1B of loans in our Energy business line & ~$625MM loans in other businesses that have a sizable portion of their revenue related to energy or could be otherwise disproportionately negatively impacted by prolonged low oil and gas prices. ● 4The bank's entire allowance is available to cover any & all losses. The allocation of allowance for energy loans reflects our robust allowance methodology which contains quantitative and qualitative components. Net Loan Charge-offs($ in millions) (bps) Normal Net Charge-Offs ~40 bps1 273 266 349 357 367 1,893 2,067 2,361 2,898 3,193 3.9 4.2 4.7 5.9 6.5 4Q14 1Q15 2Q15 3Q15 4Q15 NALsCriticized as a % of Total Loans Criticized Loans2($ in millions)Normal Criticized Loans of ~8.5% of Total Loans1 Allowance for Credit Losses($ in millions) Net charge-offs of $26MM• $33MM in energy3• Strong recoveries in other businessesCriticized loans up $295MM• $372MM increase in energy3 to $1.4BNALs of $367MM or 0.8% of total loans • $35MM increase in energy3 to $161MMAllowance up $9MM to 1.29% of total loans• Energy reserve4 up, to >4% of energy3 loans 635 640 668 670 679 1.22 1.22 1.24 1.27 1.29 4Q14 1Q15 2Q15 3Q15 4Q15 Allowance for Loan Losses as a % of total loans 12 Noninterest Income Increased 2%Strong Commercial Lending fees 4Q15 compared to 3Q15 ● 1Including impact of accounting presentation of a card program of $45MM in 4Q15, $48MM in 3Q15 & $44MM in both 2Q15 & 1Q15. ● 2Impact of changes in interest rate curve on the credit spread of debt that is swapped from fixed to floating interest rate. 225 255 261 264 270 4Q14 1Q15 2Q15 3Q15 4Q15 Noninterest Income1($ in millions) Noninterest income increased $6MM + $8MM Commercial Lending fees (primarily syndication fees) + $3MM Card fees - $2MM Service Charges on Deposits - $2MM Fiduciary - $3MM Other noninterest income+ $6MM Deferred comp (offset in expenses)- $4MM Warrant income- $3MM Hedge ineffectiveness income2

13 Noninterest Expenses IncreaseReflects Technology & Regulatory Headwinds 4Q15 compared to 3Q15 ● 1Including impact of accounting presentation of a card program of $45MM in 4Q15, $48MM in 3Q15 & $44MM in both 2Q15 & 1Q15. Noninterest expenses increased $28MM + $ 22MM Salaries & benefits expense + Technology-related contract labor+ Regulatory-related staffing+ $ 4MM Staff insurance (seasonal)+ $ 6MM Deferred comp (offset in net interest income) + $ 3MM 3Q15 Stock comp forfeiture + $3MM Litigation-related release in 3Q15 + $2MM Consultant Fees (other expense) 419 459 436 461 489 4Q14 1Q15 2Q15 3Q15 4Q15 Noninterest Expenses1($ in millions) 14 19% 21% 23% 24% 29% 28% 58% 53% 42% 50%47% 79% 76% 66% 79% 2011 2012 2013 2014 4Q15 Dividends Equity Repurchases Active Capital ManagementIncreased shares repurchased 1Outlook as of 1/19/16 ● 2See Supplemental Financial Data slides for a reconciliation of non-GAAP financial measures. ●3Shares & warrants repurchased under equity repurchase program. Shareholder Payout2015 Capital Plan Target1: Up to $393MM equity repurchases over five quarters (2Q15 through 2Q16)  4Q15: 1.5MM shares for $65MM  3Q15: 1.2MM shares for $59MM  2Q15: 1.0MM shares & 500,000 warrants for $59MM  Pace of buyback linked to financial performance & balance sheet movement $31.40 $33.36 $35.64 $37.72 $39.41 2011 2012 2013 2014 2015 Tangible Book Value Per Share2 3 Dividends Per Share Growth 0.40 0.55 0.68 0.79 0.83 2011 2012 2013 2014 2015

15 Outlook as of 1/19/16 FY16 compared to FY15 Average loans Modest growth, in line with GDP growth • Continued decline in Energy more than offset by increases in most remaining businesses• Continued focus on pricing and structure discipline Net interest income Higher• Benefit from December 2015 rise in short-term rates• Loan growth and slightly larger securities portfolio more than offset higher funding costs Provision Higher• Increase in net charge-offs, but remain below historical normal levels• Reserve build for loan growth and potential further deterioration from cyclically strong levels Noninterest income Modest growth • Growth primarily in Merchant Processing Services, Government Card and Commercial Card fees • Continued focus on cross-sell opportunities, including wealth management products such as fiduciary and brokerage services Noninterest expenses Higher, with continued expense discipline & focus on driving efficiencies • FY15 benefitted from $33MM legal reserve release which is offset by lower pension expense• Increases in technology projects & regulatory expenses• Increase in outside processing in line with growing revenue• FDIC surcharge related to recent regulatory proposal • Typical inflationary pressures (merit raises, staff insurance, occupancy, etc.) Management 2016 OutlookAssuming continuation of current economic & low rate environment 16 Interest Rate SensitivityRemain well positioned for rising rates At 12/31/15 ● 1Source: Bloomberg ● For methodology see the Company’s Form 10-Q, as filed with the SEC. Estimates are based on simulation modeling analysis. Estimated Net Interest Income: Annual (12 month) SensitivitiesBased on Various AssumptionsAdditional Scenarios are Relative to 4Q15 Standard Model($ in millions) ~110 ~180 ~190 ~200 ~210 ~250 ~310 Up 100bps Addl. $3BDepositDecline Addl.20%Increasein Beta Addl. $1BDepositDecline 4Q15StandardModel Addl.~3%LoanGrowth Up 300bps Estimated Net Interest Income: 2016 Sensitivity Based on Market Expectations for 1 Month LIBOR($ in millions) ~2 ~10 ~20 ~25 1Q16 2Q16 3Q16 4Q16 ~90 bps Avg. 1 month LIBOR from Implied Forward Curve1Projected Quarterly Increase to Net Interest Income ~45 bps ~60 bps ~75 bps

Appendix 18 Loans by Business and Market Average $ in billions ● 1Other Markets includes Florida, Arizona, the International Finance Division and businesses that have a significant presence outside of the three primary geographic markets.  Middle Market: Serving companies with revenues generally between $20-$500MM  Corporate Banking: Serving companies (and their U.S. based subsidiaries) with revenues generally over $500MM  Small Business: Serving companies with revenues generally under $20MM By Line of Business 4Q15 3Q15 4Q14 Middle MarketGeneralEnergyNational Dealer ServicesEntertainmentTech. & Life SciencesEnvironmental Services $13.03.26.20.73.30.9 $13.33.36.00.73.30.9 $13.33.55.70.62.71.0 Total Middle Market $27.3 $27.5 $26.8 Corporate BankingUS BankingInternational 2.41.7 2.41.7 2.71.8 Mortgage Banker Finance 1.7 2.1 1.4 Commercial Real Estate 4.6 4.4 4.2 BUSINESS BANK $37.7 $38.1 $36.9 Small Business 3.9 4.0 3.8 Retail Banking 1.9 1.9 1.8 RETAIL BANK $5.8 $5.9 $5.6 Private Banking 5.0 5.0 4.9 WEALTH MANAGEMENT 5.0 $5.0 $4.9 TOTAL $48.5 $49.0 $47.4 By Market 4Q15 3Q15 4Q14 Michigan $13.0 $13.2 $13.2 California 17.0 16.8 15.8 Texas 10.9 11.0 11.3 Other Markets1 7.6 8.0 7.1 TOTAL $48.5 $49.0 $47.4

19 Loans by Business and Market Average $ in billions ● 1Other Markets includes Florida, Arizona, the International Finance Division and businesses that have a significant presence outside of the three primary geographic markets.  Middle Market: Serving companies with revenues generally between $20-$500MM  Corporate Banking: Serving companies (and their U.S. based subsidiaries) with revenues generally over $500MM  Small Business: Serving companies with revenues generally under $20MM By Line of Business 2015 2014 Middle MarketGeneralEnergyNational Dealer ServicesEntertainmentTech. & Life SciencesEnvironmental Services $13.33.46.00.73.10.9 $13.43.35.60.62.50.9 Total Middle Market $27.4 $26.3 Corporate BankingUS BankingInternational 2.51.8 2.71.8 Mortgage Banker Finance 1.8 1.3 Commercial Real Estate 4.4 4.1 BUSINESS BANK $37.9 $36.2 Small Business 3.9 3.8 Retail Banking 1.9 1.8 RETAIL BANK $5.8 $5.6 Private Banking 4.9 4.8 WEALTH MANAGEMENT $4.9 $4.8 TOTAL $48.6 $46.6 By Market 2015 2014 Michigan $13.2 $13.3 California 16.6 15.4 Texas 11.2 11.0 Other Markets1 7.6 6.9 TOTAL $48.6 $46.6 20 Deposits by Business and Market Average $ in billions ● 1Other Markets includes Florida, Arizona, the International Finance Division and businesses that have a significant presence outside of the three primary geographic markets. ● 2Finance/ Other includes items not directly associated with the geographic markets or the three major business segments.  Middle Market: Serving companies with revenues generally between $20-$500MM  Corporate Banking: Serving companies (and their U.S. based subsidiaries) with revenues generally over $500MM  Small Business: Serving companies with revenues generally under $20MM By Line of Business 4Q15 3Q15 4Q14 Middle MarketGeneralEnergyNational Dealer ServicesEntertainmentTech. & Life SciencesEnvironmental Services $16.00.70.30.16.30.2 $16.20.60.20.16.70.2 $15.80.70.20.16.20.1 Total Middle Market $23.6 $24.0 $23.1 Corporate BankingUS BankingInternational $3.32.4 2.72.2 3.31.9 Mortgage Banker Finance 0.6 0.7 0.5 Commercial Real Estate 1.8 1.8 2.1 BUSINESS BANK $31.7 $31.4 $30.9 Small Business 3.2 3.1 2.9 Retail Banking 20.0 19.9 19.4 RETAIL BANK $23.2 $23.0 $22.3 Private Banking 4.4 4.2 4.1 WEALTH MANAGEMENT $4.4 $4.2 $4.1 Finance/ Other2 0.4 0.5 0.5 TOTAL $59.7 $59.1 $57.8 By Market 4Q15 3Q15 4Q14 Michigan $22.1 $21.9 $21.6 California 18.5 18.4 18.0 Texas 10.8 10.8 10.8 Other Markets1 7.9 7.5 6.9 Finance/ Other2 0.4 0.5 0.5 TOTAL $59.7 $59.1 $57.8

21 Deposits by Business and Market Average $ in billions ● 1Other Markets includes Florida, Arizona, the International Finance Division and businesses that have a significant presence outside of the three primary geographic markets. ● 2Finance/ Other includes items not directly associated with the geographic markets or the three major business segments.  Middle Market: Serving companies with revenues generally between $20-$500MM  Corporate Banking: Serving companies (and their U.S. based subsidiaries) with revenues generally over $500MM  Small Business: Serving companies with revenues generally under $20MM By Line of Business 2015 2014 Middle MarketGeneralEnergyNational Dealer ServicesEntertainmentTech. & Life SciencesEnvironmental Services $15.90.70.20.16.30.2 $14.90.60.20.15.80.1 Total Middle Market $23.4 $21.7 Corporate BankingUS BankingInternational 2.82.2 2.81.8 Mortgage Banker Finance 0.6 0.5 Commercial Real Estate 1.9 1.7 BUSINESS BANK $30.9 $28.5 Small Business 3.1 2.8 Retail Banking 19.8 19.2 RETAIL BANK $22.9 $22.0 Private Banking 4.1 3.8 WEALTH MANAGEMENT $4.1 $3.8 Finance/ Other2 0.4 0.5 TOTAL $58.3 $54.8 By Market 2015 2014 Michigan $21.9 $21.0 California 17.8 16.1 Texas 10.9 10.8 Other Markets1 7.3 6.4 Finance/ Other2 0.4 0.5 TOTAL $58.3 $54.8 22 Energy Line of Business30+ Years experience with strong performance through past cycles At 12/31/15 Natural Gas 13% Oil40% Mixed17% 454 535 463 481 460566 535 530 513 491 2,539 2,496 2,316 2,249 2,119 3,559 3,566 3,309 3,243 3,070 4Q14 1Q15 2Q15 3Q15 4Q15 Midstream Services Exploration & Production Energy Business Line Loans ($ in millions; Period-end) Exploration & Production 69% Midstream15% Services16% Natural Gas 11% Oil40% Mixed18% Diverse Customer Base(Based on period-end outstandings)  Granular portfolio: ~200 customers  $3.1B in loans at 12/31/15, decreased $173MM, or 5%, from 9/30/15  49% line utilization at 12/31/15  Negative credit migration continuing with low prices  Criticized loans $1.2B, or 40% • Prudently downgrading loans based on distressed cash flows due to fall in energy prices• Overall, collateral coverage remains strong  Nonaccrual loans $132MM  Net charge-offs $27MM in 4Q15  Appropriately increased reserves for energy loans for past 4 quarters

23 At 12/31/15 ● 1Source: Mortgage Bankers Association (MBA) Mortgage Finance Forecast as of 12/18/15 ● 2$ in billions; 4Q15 estimated ● 3Based on MBA annual mortgage origination estimates 566 614 923 1,53 5 1,48 3 1,50 7 1,9 96 2,09 4 1,73 7 1,81 5 1,60 5 1,10 9 886 1 ,319 1, 595 1,39 7 1,39 9 2 ,089 2,13 6 1,74 2 200 300 400 500 600 700 800 900 1Q1 1 2Q1 1 3Q1 1 4Q1 1 1Q1 2 2Q1 2 3Q1 2 4Q1 2 1Q1 3 2Q1 3 3Q1 3 4Q1 3 1Q1 4 2Q1 4 3Q1 4 4Q1 4 1Q1 5 2Q1 5 3Q1 5 4Q1 5 Actual MBAMortgageOriginationVolumes Average Loans($ in millions) Mortgage Banker Finance50 Years experience with reputation for consistent, reliable approach MBA Mortgage Originations Forecast1($ in billions) 330 395 381 360 293 360 355 312 1Q15Actual 2Q15Actual 3Q15Actual 4Q15 1Q16 2Q16 3Q16 4Q16 Purchase Refinance 1,2  Provide warehouse financing: bridge from residential mortgage origination to sale to end market  Extensive backroom provides collateral monitoring and customer service  Focus on full banking relationships  Granular portfolio with 100+ relationships  Market share approx. doubled over past five years3  Underlying mortgages are typically related to home purchases as opposed to refinancesAs of 4Q15: • Comerica: ~75% purchase • Industry: 56% purchase1 24 National Dealer Services65+ years of floor plan lending At 12/31/15 ● 1Other includes obligations where a primary franchise is indeterminable (rental car and leasing companies, heavy truck, recreational vehicles, and non-floor plan loans) Toyota/Lexus15% Honda/Acura 13% Ford 10% GM 8% Chrysler 11% Mercedes 3% Nissan/ Infiniti 7%Other European 12% Other Asian 12% Other19% Franchise Distribution(Based on period-end loan outstandings) Geographic DispersionCalifornia 64% Texas 7%Michigan 18% Other 11% Average Loans($ in billions)  Top tier strategy  Focus on “Mega Dealer” (five or more dealerships in group)  Strong credit quality  Robust monitoring of company inventory and performance 1.9 1.7 1.3 1.5 1.9 2.3 2.3 2.5 2.8 3.1 2.9 3.2 3.2 3.5 3.2 3.4 3.5 3.6 3.5 3.7 3.8 3.6 3.1 3.4 3.8 4.3 4.3 4.6 4.9 5.1 4.9 5.3 5.3 5.7 5.5 5.7 5.9 6.0 6.0 6.2 1Q1 1 2Q1 1 3Q1 1 4Q1 1 1Q1 2 2Q1 2 3Q1 2 4Q1 2 1Q1 3 2Q1 3 3Q1 3 4Q1 3 1Q1 4 2Q1 4 3Q1 4 4Q1 4 1Q1 5 2Q1 5 3Q1 5 4Q1 5 Floor Plan

25 Technology and Life Sciences20+ Years experience provides competitive advantage At 12/31/15 ● 1TLS net charge-offs to avg. TLS loans  National business headquartered in Palo Alto, CA, with 14 offices in U.S. & Toronto  Products & services tailored to meet needs of companies throughout their lifecycle  Equity Funds Services helps drive avg. loan growth (up ~$1B over past 4 years)  Strong relationships with top-tier investors  Granular portfolio  Closely monitor cash balances 1.3 1.8 2.0 2.5 3.1 4.1 5.0 5.1 5.8 6.3 2011 2012 2013 2014 2015 Average Loans Average Deposits Average Loans & Deposits ($ in billions) Net Charge-offs1(In basis points) (27) 49 - 26 69 168 24 80 57 61 89 108 200 4 200 5 200 6 200 7 200 8 200 9 201 0 201 1 201 2 201 3 201 4 201 5 Early Stage~10% Growth~35% Late Stage~10% Leveraged Finance~5% Customer Segment Overview(based on period-end loans) Equity Fund Services~40% Total $3.4B Michigan$267 7% California$1,709 45% Texas$1,113 29%Florida$96 3% Other$623 16% CRE by Market2($ in millions; Based on location of property) 26 Commercial Real Estate Line of Business At 12/31/15 ● 1Includes CRE line of business loans not secured by real estate. ● 2Excludes CRE line of business loans not secured by real estate. 4.0 4.4 4.6 4.4 4.3 3.9 3.7 3.7 3.8 3.8 3.7 4 .0 4.1 4.2 4.2 4.2 4.2 4 .4 4.6 2Q1 1 3Q1 1 4Q1 1 1Q1 2 2Q1 2 3Q1 2 4Q1 2 1Q1 3 2Q1 3 3Q1 3 4Q1 3 1Q1 4 2Q1 4 3Q1 4 4Q1 4 1Q1 5 2Q1 5 3Q1 5 4Q1 5 Commercial & OtherReal Estate ConstructionCommercial Mortgages Average Loans($ in billions) 6.4 6.4 6.6 6.9 7.3 4Q14 1Q15 2Q15 3Q15 4Q15 Commitments($ in billions; Based on period-end) 14% 1 Total$3,808

27 Shared National Credit (SNC) Relationships At 12/31/15 ● SNCs are not a line of business. The balances shown above are included in the line of business balances. ●SNCs are facilities greater than $20 million shared by three or more federally supervised financial institutions which are reviewed by regulatory authorities at the agent bank level.  SNC relationships included in business line balances  Approximately 773 borrowers  Comerica is agent for approx. 20%  Strategy: Pursue full relationships with ancillary business  Adhere to same credit underwriting standards as rest of loan book Period-end Loans($ in billions) Commercial Real Estate$0.67% Corporate $2.323% General$2.020%National Dealer $0.55% Energy$2.930% Entertainment$0.43% Tech. & Life Sciences$0.44% Environmental Services$0.3 3% Mortgage Banker$0.45% = Total Middle Market (65%) Total $9.8 28 Funding and Maturity Profile At 12/31/15 ● 1Face value at maturity.  Wholesale debt markets  Federal Home Loan Bank of Dallas• $-0- outstanding • $6B borrowing capacity  Brokered deposits• $-0-outstanding  Fed funds/ Repo markets Multiple Funding Sources Debt Profile by Maturity1($ in millions) 650 500 350 1,425 2016 2017 2019 2020+ Subordinated NotesSenior Notes Equity$7.6 11% Interest-Bearing Deposits$29.0 41% Noninterest-Bearing Deposits$30.8 44% Wholesale Debt$3.1 4% Funding ProfileAt December 31, 2015($ in billions)

Senior Unsecured/Long-Term Issuer Rating S&P Moody’s Fitch Cullen Frost A A2 -- BB&T A- A2 A+ BOK Financial A- A2 A Comerica A- A3 A M&T Bank A- A3 A KeyCorp BBB+ Baa1 A- Fifth Third BBB+ Baa1 A SunTrust BBB+ Baa1 A- Huntington BBB Baa1 A- Regions Financial BBB Baa3 BBB Zions Bancorporation BBB- Ba1 BBB- First Horizon National Corp BB+ Baa3 BBB- Wells Fargo & Company A A2 AA- U.S. Bancorp A+ A1 AA JP Morgan A- A3 A+ PNC Financial Services Group A- A3 A+ Bank of America BBB+ Baa1 A 29 Holding Company Debt Rating As of 1/14/16 ● Source: SNL Financial ● Debt Ratings are not a recommendation to buy, sell, or hold securities. Pee r Ba nks Larg e Ba nks Supplemental Financial DataReconciliation of non-GAAP financial measures with financial measures defined by GAAP ($ in millions) The Tier 1 common capital ratio removes preferred stock and qualifying trust preferred securities from Tier 1 capital as defined by and calculated in conformity with Basel I risk-based capital rules in effect through 12/31/14. Effective 1/1/15, regulatory capital components and risk-weighted assets are defined by and calculated in conformity with Basel III risk-based capital rules. The tangible common equity ratio removes preferred stock and the effect of intangible assets from capital and the effect of intangible assets from total assets. Tangible common equity per share of common stock removes the effect of intangible assets from common shareholders equity per share of common stock.● The Corporation believes these measurements are meaningful measures of capital adequacy used by investors, regulators, management and others to evaluate the adequacy of common equity and to compare against other companies in the industry. ● n/a – not applicable. ● 1Tier 1 Capital and risk-weighted assets as defined by Basel I risk-based capital rules. 12/31/15 9/30/15 12/31/14 12/31/13 12/31/12 12/31/11 Tier 1 and Tier 1 common capital1Risk-weighted assets1Tier 1 and Tier 1 common capital ratio n/an/an/a n/an/an/a 7,16968,26910.50% 6,89564,82510.64% 6,70566,11510.14% Common shareholders’ equityLess: GoodwillLess: Other intangible assets $7,57463514 $7,62263514 $7,40263515 $7,15063517 $6,93963522 $6,86563532 Tangible common equity $6,925 $6,973 $6,752 $6,498 $6,282 $6,198 Total assetsLess: GoodwillLess: Other intangible assets $71,89563514 $71,01263514 $69,18663515 $65,22463517 $65,06663522 $61,00563532 Tangible assets $71,246 70,363 $68,536 $64,572 $64,409 $60,338Common equity ratio 10.54% 10.73% 10.70% 10.97% 10.67% 11.26%Tangible common equity ratio 9.72 9.91 9.85 10.07 9.76 10.27 Common shareholders’ equity $7,574 $7,622 $7,402 $7,150 $6,939 $6,865Tangible common equity 6,925 6,973 $6,752 $6,498 $6,282 $6,198Shares of common stock outstanding (in millions) 176 177 179 182 188 197 Common shareholders’ equity per share of common stock $43.11 $43.02 $41.35 $39.22 $36.86 $34.79 Tangible common equity per share of common stock 39.41 39.36 37.72 35.64 33.36 31.40 30