Exhibit 21

ST. JUDE MEDICAL, INC.

SUBSIDIARIES OF THE REGISTRANT

as of December 29, 2007

St. Jude Medical, Inc. Wholly Owned Subsidiaries:

• Pacesetter, Inc. - Sylmar, California, Scottsdale, Arizona, and Maven, South Carolina
(Delaware corporation) (doing business as St. Jude Medical Cardiac Rhythm Management Division)

• St. Jude Medical S.C., Inc. – Austin, Texas (Minnesota corporation)

– Bio-Med Technologies Limited (Pennsylvania corporation)

– San Diego Pace, Inc. (California corporation)

• St. Jude Medical Europe, Inc. - St. Paul, Minnesota (Delaware corporation)

– Brussels, Belgium branch

• St. Jude Medical Canada, Inc. - Mississauga, Ontario and St. Hyacinthe, Quebec
(Ontario, Canada corporation)

• St. Jude Medical (Shanghai) Co., Ltd. – Shanghai, China (Chinese corporation)

– Beijing, Shanghai and Guangzhou representative offices

• St. Jude Medical, Inc., Cardiac Assist Division - St. Paul, Minnesota (Delaware corporation)
(Assets of St. Jude Medical, Inc., Cardiac Assist Division sold to Bard 1/19/96)

• St. Jude Medical Australia Pty., Ltd. – Sydney, Australia (Australian corporation)

• St. Jude Medical Brasil, Ltda. - Sao Paulo and Belo Horizonte, Brazil (Brazilian corporation)

• St. Jude Medical, Atrial Fibrillation Division, Inc. (Formerly St. Jude Medical, Daig Division, Inc.) - Minnesota and California (Minnesota corporation)

– Endocardial Solutions NV/SA (Belgian Corporation)

• St. Jude Medical Colombia, Ltda. - Bogota, Colombia (Colombian corporation)

• St. Jude Medical ATG, Inc. - Maple Grove, Minnesota (Minnesota corporation)

• St. Jude Medical (Thailand) Co., Ltd. – Bangkok, Thailand (Thailand corporation)

• Irvine Biomedical, Inc. – Irvine, California (California corporation)

• Frank Merger Corporation – (Delaware corporation)

• St. Jude Medical, Cardiology Division, Inc. (Formerly Velocimed, Inc.) - Minnesota (Delaware corporation)

• Light Merger Corporation – (Minnesota Corporation)

• St. Jude Medical Argentina S.A. – Buenos Aires, Argentina (Argentinean corporation)

• Advanced Neuromodulation Systems, Inc. – Plano, Texas (Texas Corporation)

– Quest Acquisition Corporation – Plano, Texas (Delaware Corporation)

– Hi-Tronics Designs, Inc. – Budd Lake, New Jersey (New Jersey Corporation)

– Neuro-Regeneration, Inc. – Plano, Texas (Texas Corporation)

– MicroNet Medical, Inc. – Plano, Texas (Minnesota Corporation)

– Hug Centers of America I, Inc. – Plano, Texas (Delaware Corporation)

– SPAC Acquisition Corp. – Wilmington, Delaware (Delaware Corporation)

– Advanced Neuromodulation Systems, UK Limited (United Kingdom corporation)

• SJM International, Inc. - St. Paul, Minnesota (Delaware corporation)

– Tokyo, Japan branch

SJM International, Inc. Wholly Owned Legal Entities (Directly and Indirectly):

• St. Jude Medical Luxembourg S.à r.l. (Luxembourg corporation)

– St. Jude Medical Nederland B.V. (Netherlands corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg S.à r.l.)

– St. Jude Medical Puerto Rico B.V. (Netherlands corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg S.à r.l.)

– St. Jude Medical Puerto Rico LLC (Puerto Rican corporation) (wholly owned subsidiary of St. Jude Medical Puerto Rico B.V.)

– St. Jude Medical AB (Swedish corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg S.à r.l.)

– SJM Coordination Center BVBA (Belgian corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg S.à r.l.)

– St. Jude Medical Holdings B.V. (Netherlands corporation) (wholly owned subsidiary of St. Jude Medical Luxembourg S.à r.l.)

– St. Jude Medical Japan Co., Ltd. (Japanese corporation) (wholly owned subsidiary of St. Jude Medical Holdings B.V.)

– St. Jude Medical India Private Limited (Indian corporation) (wholly owned subsidiary of St. Jude Medical Holdings B.V.)

– St. Jude Medical (Singapore) Pte. Ltd. (Singaporean corporation) (wholly owned subsidiary of St. Jude Medical Holdings B.V.)

– St. Jude Medical (Malaysia) Sdn Bhd (Malaysian corporation) (wholly owned subsidiary of St. Jude Medical Holdings B.V.)

– St. Jude Medical Taiwan Co. (Taiwan corporation) (wholly owned subsidiary of St. Jude Medical Holdings B.V.)

– St. Jude Medical Korea YH (Korean corporation) (wholly owned subsidiary of St. Jude Medical Holdings B.V.)

– St. Jude Medical (Hong Kong) Limited - Central, Hong Kong (Hong Kong corporation)

– Beijing, China representative office

– Mumbai, New Delhi, Calcutta, Chennai and Bangalore, India branch offices

• St. Jude Medical Sweden AB (Swedish corporation)

• St. Jude Medical Danmark A/S (Danish corporation)

• St. Jude Medical (Portugal) - Distribuição de Produtos Médicos, Lda. (Portuguese corporation)

• St. Jude Medical Export Ges.m.b.H. (Austrian corporation)

• St. Jude Medical Medizintechnik Ges.m.b.H. (Austrian corporation)

• St. Jude Medical Italia S.p.A. (Italian corporation)

• St. Jude Medical Belgium (Belgian corporation)

• St. Jude Medical España S.A. (Spanish corporation)

• St. Jude Medical France S.A.S. (French corporation)

• St. Jude Medical Finland O/y (Finnish corporation)

• St. Jude Medical Sp.zo.o. (Polish corporation)

• St. Jude Medical GmbH (German corporation)

• St. Jude Medical Kft (Hungarian corporation)

• St. Jude Medical UK Limited (United Kingdom corporation)

• St. Jude Medical (Schweiz) AG (Swiss corporation)

• UAB “St. Jude Medical Baltic” (Lithuanian corporation)

• St. Jude Medical Norway AS (Norwegian corporation)