Exhibit 4.1

 NUMBER  SHARES  COUNTERSIGNED:  BROADRIDGE CORPORATE ISSUER SOLUTIONS, LLC  TRANSFER AGENT  BY:  AUTHORIZED SIGNATURE  A  CUSIP G0437V 10 7  SEE REVERSE FOR CERTAIN DEFINITIONS  This CerTifies ThaT:  o r D i n a r Y s h a r e s  CHIEF FINANCIAL OFFICER  AprinoiA TherApeuTics inc.  INCORPORATED UNDER THE LAWS OF THE CAYMAN ISLANDS  is The owner of  FULLY PAID AND NON-ASSESSABLE ORDINARY SHARES OF THE PAR VALUE OF $0.40 EACH OF  AprinoiA TherApeuTics inc.   transferable on the books of the Company in person or by attorney upon surrender of this certificate duly endorsed or assigned. This certificate and the shares represented hereby are subject to the laws of the Cayman Islands, and to the Memorandum and Articles of Association of the Company, as now or hereafter amended.  This certificate is not valid unless countersigned by the Transfer Agent.  Witness the facsimile seal of the Company and the facsimile signatures of its duly authorized officers.  PROOF  PROOF  PROOF  PROOF  PROOF  PROOF  PROOF  PROOF