EX-10.2 6 ex10-2.htm

 

Exhibit 10.2

 

PATENT ASSIGNMENT AGREEMENT

 

This PATE T ASSIGNMENT AGREEMENT (this “Assignment”), dated as of May 17,202l (the “Effective Date”), is made and entered into by and between SPINALCYTE LLC, a Texas limited liability company (“SpinalCyte”) and FIBROBIOLOGICS LLC, a Texas limited liability company ( “FibroBiologics”). FibroBiologics and SpinalCyte are each referred to individually as a “ “ and collectively as the “Parties.”

 

RECITALS

 

WHEREAS, SpinalCyte is the owner of all right, title and interest in and to the Patents (as defined below);

 

WHEREAS, Fibrobiologics is a wholly owned subsidiary of SpinalCyte, and SpinalCyte wishes to sell and transfer all right, title and interest in the Patents to FibroBiologics for further development of the patented technology as well as securing and maintaining related patent rights;

 

WHEREAS, FibroBiologics wishes to purchase and receive from SpinalCyte all right, title and interest in the Patents from SpinalCyte; and

 

WHEREAS, in consideration of this assignment, the parties have separately agreed to a cross license of patents.

 

NOW, THEREFORE, in consideration of the foregoing and the respective representations, warranties, covenants and agreements set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereto agree as follows:

 

1. Patents. “Patents” means the United States patents and patent applications listed on Exhibit A hereto, all reissues, reexaminations, extensions, continuations, continuations in part, continuing prosecution applications, provisionals and divisions of such patents granted in the United States, and any United States or foreign patents or patent applications that claim priority to any of the foregoing, whether or not listed on Exhibit A.

 

2. Assignment. SpinalCyte hereby irrevocably transfers and assigns to FibroBiologics, and FibroBiologics hereby accepts, all right, title and interest in and to the Patents, free and clear of any and all debts, liens, encumbrances, obligations and liabilities of any kind, and all income, royalties, damages, claims, and payments now or hereafter due or payable with respect to the Patents; all causes of action for past, present, or future infringement based upon, relating to, or arising out of any of the Patents; the right to claim priority to all patents and applications (throughout the world) of any kind that claim priority to or otherwise issue from any of the Patent(s); and all rights corresponding to the Patents throughout the world.

 

3. Representations and Warranties; Disclaimer of Warranties. SpinalCyte hereby represents, warrants and covenants that (a) SpinalCyte has the right, and full power and authority, on behalf of SpinalCyte to make the assignments as well as the representation, warranties and covenants made herein; (b) SpinalCyte has not executed nor will it execute any agreement in conflict herewith; and (c) SpinalCyte will not challenge or dispute the ownership, validity or enforceability of the Patents either directly or indirectly, nor allow any person or entity under SpinalCyte control to do so. SpinalCyte ASSIGNS THE PATENTS TO FibroBiologics “AS IS” AND MAKES NO WARRA TIES OF ANY KIND, EXPRESS OR IMPLIED, IN RELATION TO THE PATENTS. WITHOUT LIMITING THE FOREGOING, SpinalCyte DISCLAIMS ANY AND ALL IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, AND NON-INFRINGEMENT.

 

1

 

 

4. Further Assurances. SpinalCyte agrees to execute and deliver or cause to be executed and delivered to FibroBiologics, at FibroBiologics’ expense (but without further compensation to SpinalCyte), such further instruments of transfer and conveyance, to execute and deliver or cause to be executed and delivered all applications and all divisional, continuing and reissue applications, to execute and deliver or cause to be executed and delivered all renewals, to make or cause to be made all rightful oaths, and to take or cause to be taken such other actions as may reasonably request to carry out the transfer of the Patents conveyed herein. SpinalCyte will, and will cause persons under its control to, communicate to FibroBiologics, its successors, legal representatives and assigns, any facts known to them respecting the Patents, testify in any legal proceeding, and generally do everything reasonably possible to aid FibroBiologics, its successors, legal representatives and assigns, to obtain and enforce and protect the Patents in all countries, provided only that FibroBiologics shall pay, or reimburse SpinalCyte for, all reasonable out of pocket expenses incurred by SpinalCyte incident to the performance of its obligations under this paragraph.

 

5. Governing Law. This Agreement shall be governed by and interpreted in accordance with the laws and regulations of Texas, U.S.A., excluding any conflict of laws rule that would result in the application of the laws of another jurisdiction.

 

6. Headings. Headings of the various articles and sections, where used herein, are merely present for convenience and shall not be used in construing this Agreement.

 

7. Entire Agreement. This Agreement and any Appendices attached hereto constitute the entire agreement and understanding between the Parties with respect to the subject matter hereof and supersedes any prior agreement, understanding or arrangement between the Pa11ies, whether oral or in writing, with respect to the subject matter hereof. No representation, undertaking or promise shall be taken to have been given or be implied from anything said or written in negotiations between the Parties prior to this Agreement except as expressly stated in this Agreement.

 

8. Modifications. This Agreement may not be modified or amended unless such modification or an1endment is made in writing and is signed by the Pat1ies.

 

9. No Waiver. Failure of either Party to enforce or exercise, at any time or for any period, any term of this Agreement, does not constitute, and shall not be construed as, a waiver of such term and shall not affect the right later to enforce such tem1 or any other term herein contained.

 

10. Severability. If any provision of this Agreement should be void or held illegal or unenforceable, the other provisions shall not be affected and the Parties will replace any provision held void, illegal or unenforceable with provisions which will achieve as far as possible the intention or results sought to be achieved by the void provisions.

 

11. Counterparts. This Agreement may be executed in two (2) counterparts, each of which shall be deemed an original, but which together shall constitute one and the same instrument.

 

12. Signatures. Facsimile signatures (including pdf signatures) transmitted by the Parties hereto shall be deemed as effective as original signatures on this Agreement.

 

[Signature Page Attached]

 

2

 

 

IN WITNESS WHEREOF, the Parties hereto have caused this Assignment to be executed by their respective duly authorized officers as of Effective Date.

 

SpinalCyte, LLC   FibroBiologics, LLC
         
By: /s/ Pete O’Heeron   By: /s/ Pete O’Heeron
Name: Pete O’Heeron   Name: Pete O’Heeron
Title: CEO   Title: CEO

 

[Signature Page to Patent Assignment Agreement]

 

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Schedule A

Patents and Patent Applications

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0002A U.D I   Australia   2011253785   12/2/2011   2011253785   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002AU.D2   Australia   2013257540   11/19/2013   2013257540   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002AU.D3   Australia   2015202319   5/6/2015   2015202319   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002A U.D4   Australia   2017206234   7/20/2017   2017206234   METHODS AND COMPOSITIO S FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002AU.D5   Australia   2018220112   8/23/2018   2018220112   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002CN.D I   China   201110261353.3   8/9/2011   ZL 201110261353.3   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002JP.Dl   Japan   2012-241637   11/1/2012   6151006   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002JP.D2   Japan   2015-080729   4/10/2015       METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR

 

4

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0002JP.D3   Japan   2017-184649   9/26/2017   6676022   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     

AMTK.P0002JP.D3D I

   Japan   2020-000328   1/6/2020       METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BTOREACTOR
                     
AMTK.P0002JP.D4   Japan   2017-184650   9/26/2017       METHODSAND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002US.C I   United States of America   13/185472   7/18/2011   9138460   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002US.D1   United States of America   12/775720   5/7/2010   8728495  

METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE

USING AN IN VIVO BTOREACTOR

                     
AMTK.P0002US.D2   United States of America   12/775736   5/7/20IO   9545432   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002US.D2C I   United States of America   15/371994   12/7/2016   10052410   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002US.D2C 2   United States of America   16/038915   7/18/2018   10806824   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002US.D2C 3   United States of America   16/865926   5/4/2020       METHODSAND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN TN VIVO BIOREACTOR

 

5

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0002US. D3   United States of America   12/775753   5/7/2010   8298560   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002US.D4   United States of America   12/775765   5/7/2010   9320776   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0002US.D5   United States of America   12/775771   5/7/2010   9533024   METHODSAND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0003CN   China   201280063195.3   6/20/2014      

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE

                     
AMTK.P0003CN.Dl   China   201711263200.6   12/5/2017       FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE
                     
AMTK.P0003ECH   Switzerland   12846950.9       2776556  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003ECH.D1   Switzerland   17192969.8       3290511  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003EDE   Germany   12846950.9       2776556  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003EDE.D I   Germany   17192969.8       3290511   FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE
                     
AMTK.P0003EES   Spain   12846950.9       2776556   FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE
                     
AMTK.P0003EES.DI   Spain   17192969.8       3290511  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003EFR   France   12846950.9       2776556   FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE

 

6

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0003EFR.DI   France   I7192969.8       3290511   FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE
                     
AMTK.P0003EGB   United Kingdom   12846950.9       2776556  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003EGB.DI   United Kingdom   17192969.8       3290511  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003EHK   Hong Kong   14111200.7   11/4/2014   HK! 197832   FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE
                     
AMTK.P0003EHK.D I   Hong Kong   18111368.1   9/5/2018   HK1252036   FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE
                     
AMTK.P0003EIE.DI   Ireland   17192969.8       3290511  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DJSC

DISEASE

                     
AMTK.P0003EIT   Italy   12846950.9       2776556  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003EIT.DI   Italy   17192969.8       3290511  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003EP   European Patent Office   12846950.9   5/21/2014   2776556  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003EP.D I   European Patent Office   17192969.8   9/25/2017   3290511  

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003EP.D2   European Patent Office   20186304.0   7/16/2020      

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003IN   India   391 I/DELNP/2014   5/15/2014       FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE
                     
AMTK.P0003US   United States of America   14/357558   5/9/2014      

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0003 US.DI   United States of America   15/957741   4/19/2018      

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

 

7

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0003US.Pl   United States of America   61/557479   11/9/2011      

FIBROBLASTS FOR TREATMENT OF

DEGENERATIVE DISC DISEASE

                     
AMTK.P0003US.P2   United States of America   61/691391   8/21/2012       FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE
                     
AMTK.P0003WO   Patent Cooperation Treaty   PCT/US2012/064101   11/8/2012      

FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC

DISEASE

                     
AMTK.P0004AU   Australia   2013299505   2/2/2015   2013299505   GENERATION OF CARTILAGE EX VIVO FROM FIBROBLASTS
                     
AMTK.P0004AU.Dl   Australia   2017201708   3/13/2017   2017201708   GENERATION OF CARTILAGE EX VIVO FROM FIBROBLASTS
                     
AMTK.P0004CA   Canada   2881126   2/4/2015      

GENERATION OF CARTILAGE EX VIVO

FROM FIBROBLASTS

                     

AMTK.P0004CHK.D l

   Hong Kong   42020009561.0   6/18/2020       GENERATION OF CARTILAGE EX VIVO FROM FIBROBLASTS
                     
AMTK.P0004CN   China   201380047210.X   3/l l/2015       GENERATION OF CARTILAGE EX VIVO FROM FIBROBLASTS
                     
AMTK.P0004CN.D1   China   201911186070.X   11/28/2019      

GENERATION OF

CARTILAGE EX VIVO FROM FIBROBLASTS

                     
AMTK.P0004EHK   Hong Kong   15110635.3   10/28/2015       GENERATION OF CARTILAGE EX VIVO FROM FIBROBLASTS
                     
AMTK.P0004EP   European Patent Office   13827360.2   3/4/2015      

GENERATION OF CARTILAGE EX VIVO

FROM FJBROBLASTS

                     
AMTK.P0004JN   India   1321/DELNP/2015   2/18/2015      

GENERATION OF

CARTILAGE EX VIVO

FROM FIBROBLASTS

                     
AMTK.P0004JP   Japan   2015-526709   2/9/2015   6456826   GE ERATTON OF CARTILAGE EX VIVO FROM FIBROBLASTS
                     
AMTK.P0004JP.D1   Japan   2018-032337   2/26/2018   6574502   GENERATION OF CARTILAGE EX VIVO FROM FIBROBLASTS
                     
AMTK.P0004JP.D2   Japan   2019-149332   8/16/2019      

GENERATTON OF CARTILAGE EX VIVO

FROM FIBROBLASTS

                     
AMTK.P0004US   United States of America   13/962241   8/8/2013       GENERATION OF CARTILAGE EX VIVO FROM FIBROBLASTS
                     
AMTK.P0004US.P1  

United States of

America

   61/681731   8/10/2012       GENERATION OF CARTILAGE EX VIVO FROM FIBROBLASTS

 

8

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0004 WO  

Patent

Cooperation Treaty

   PCT/US2013/054158   8/8/2013      

GENERATION OF CARTILAGE EX VIVO

FROM FIBROBLASTS

                     
AMTK.P0005AU   Australia   2014281818   12/7/2015   2014281818   ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005AU.D1   Australia   2019253856   10/23/2019       ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005CA   Canada   2915249   12/11/2015      

ADIPOSE CELLS FOR CHONDROCYTE

APP LICATIONS

                     
AMTK.P0005CN   China   201480039060.2   1/8/2016       ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005ECH   Switzerland   14813201.2       3011015   ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005EDE   Germany   14813201.2       3011015   ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005EES   Spain   14813201.2       3011015   ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005EFR   France   14813201.2       3011015   ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005EGB   United Kingdom   14813201.2       3011015   ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005EHK   Hong Kong   16110257.9   8/29/2016       ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005EIE   Ireland   14813201.2       3011015   ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005ETT   Italy   14813201.2       3011015   ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005EP   European Patent Office   14813201.2   1/6/2016   301 l015   ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS

 

9

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0005IN   India   201617001725   1/18/2016       ADIPOSE CELLS FOR CHONDROCYTE APPLTCATIONS
                     
AMTK.P0005JP   Japan   2016-521475   12/18/2015       ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005JP.D I   Japan   2020-119475   7/10/2020       ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005US   United States of America   14/304247   6/13/2014   10206954   ADIPOSE CELLS FOR CHONDROCYTE APPLTCATTONS
                     
AMTK.P0005US.C1   United States of America   16/244333   1/10/2019       ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0005US.PI   United States of America   61/836975   6/19/2013       ADIPOSE CELLS FOR CHONDROCYTE APPLTCATIONS
                     
AMTK.P000SWO   Patent Cooperation Treaty   PCT/US2014/042322   6/13/2014       ADIPOSE CELLS FOR CHONDROCYTE APPLICATIONS
                     
AMTK.P0006AU   Australia   2014317861   3/8/2016   2014317861   GENE THERAPY FOR THE REGENERATION OF CHONDROCYTESOR CARTILAGE TYPE CELLS
                     
AMTK.P0006A U.D I   Australia   2019268095   11/20/2019       GENE THERAPY FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0006CA   Canada   2923857   3/9/2016       GENE THERAPY FOR THE REGENERATJON OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0006CN   China   201480057130.7   4/18/2016       GENE THERAPY FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS

 

10

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0006EHK   Hong Kong   16112454.6   10/28/2016       GENE THERAPY FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0006EP   European Patent Office   14841529.2   4/5/2016       GENE THERAPY FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0006IN   India   201617011955   4/5/2016       GENE THERAPY FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0006JP   Japan   2016-542044   3/9/2016       GENE THERAPY FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0006JP.Dl   Japan   2020-033592   2/28/2020       GENE THERAPY FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0006US   United States of America   14/917560   3/8/2016       GENE THERAPY FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0006US.P1   United States of America   61/875509   9/9/2013       GENE THERAPY FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0006WO   Patent Cooperation Treaty   PCT/US2014/054804   9/9/2014       GENE THERAPY FOR THE REGENERATJON OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0007AU   Australia   2017207445   7/3/2018       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS

 

11

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0007CA   Canada   3011306   7/11/2018       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0007CN   China   2017800] 1692.1   8/16/2018       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0007EHK   Hong Kong   18115243.3   11/28/2018       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0007EP   European Patent Office   17739050.7   7/12/2018       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0007IN   India   201817025735   7/10/2018       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0007JP   Japan   2018-536724   7/13/2018       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0007US   United States of America   16/068096   7/3/2018       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
AMTK.P0007US.PI   United States of America   62/278635   1/14/2016       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0007US.P2   United States of America   62/413587   10/27/2016       CELLULAR BLEND FOR THE REGENERAT[ON OF CHONDROCYTES OR CARTILAGE TYPE CELLS

 

12

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0007WO   Patent Cooperation Treaty   PCT/US2017/013449   1/13/2017       CELLULAR BLEND FOR THE REGENERATION OF CHONDROCYTES OR CARTILAGE TYPE CELLS
                     
AMTK.P0008CA.D I   Canada   2925550   3/30/2016   2925550   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VTVO BIOREACTOR
                     
AMTK.P0008CA. D2   Canada   3019254   I 0/1/20 I8   3019254   USE OF CHONDROCYTE- LIKE CELLS TO TREAT A JOINT IN NEED OF REPAIR
                     
AMTK.P0008ECH   Switzerland   07763383.2       1989289   METHODSAND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008ECH.DJ   Switzerland   16195838.4       3146939   METHODS AND COMPOSITIO S FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EDE   Germany   07763383.2       1989289   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EDE.DI   Germany   16195838.4       3146939   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EES   Spain   07763383.2       1989289   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EES.Dl   Spain   16195838.4       3146939   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR

 

13

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0008EFR   France   07763383.2       1989289   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EFR.DI   France   16195838.4       3146939   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN 1N VIVO BIOREACTOR
                     
AMTK.P0008EGB   United Kingdom   07763383.2       1989289   METHODS AND COMPOSITIONS FOR REPALR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EGB.D l   United Kingdom   16195838.4       3146939   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EHK.D 1   Hong Kong   17108880.7   9/4/2017   HKl236375   METHODSAND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EIT   Italy   07763383.2       1989289   METHODSA D COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EIT.D I   Italy   16195838.4       3146939   METHODSAND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
AMTK.P0008EP.D 1   European Patent Office   16195838.4   10/26/2016   3146939   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN TN VIVO BIOREACTOR
                     
AMTK.P0017EP   European Patent Office   19795975.2   11/23/2020      

FIBROBLAST DELIVERY OF

TUMOR INHIBITORY AGENTS

                     
AMTK.P00 l 7US   United States of America   17/052830   11/4/2020      

FIBROBLAST DELIVERY OF

TUMOR INHIBITORY AGENTS

 

14

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0017US.Pl   United States of America   62/666786   5/4/2018       FIBROBLAST DELIVERY OF TUMOR INHIBITORY AGENTS
                     
AMTK.P0017WO   Patent Cooperation Treaty   PCT/US2019/030585   5/3/2019       FIBROBLAST DELIVERY OF TUMOR INHIBITORY AGENTS
                     
AMTK.P0018EP   European Patent Office   19795797.0   l l/23/2020       DE-DIFFERENTIATED FIBROBLAST- CONDITIONED MEDIA FOR STIMULATION OF DISC REGENERATION
                     
AMTK.P0018US   United States of America   17/052841   11/4/2020       DE-DIFFERENTIATED FIBROBLAST- CONDITIONED MEDIA FOR STTMULATION OF DISC REGENERATION
                     
AMTK.P0018US.PI   United States of America   62/666777   5/4/2018       DE-DIFFERENTIATED FIBROBLAST- CONDITIONED MEDIA FOR STIMULATION OF DISC REGENERATION
                     
AMTK.P00l8WO   Patent Cooperation Treaty   PCT/US2019/030570   5/3/2019       DE-DIFFERENTIATED FIBROBLAST- CONDITIONED MEDIA FOR STIMULATION OF DISC REGENERATION
                     
AMTK.P00I9EHK   Hong Kong               INTRADISCAL T- REGULATORY CELL ADMINISTRATION FOR TREATMENT OF DISC DEGENERATIVE DISEASE
                     
AMTK.P0019EP   European Patent Office   19796226.9   11/24/2020       INTRADISCAL T- REGULATORY CELL ADMINISTRATION FOR TREATMENT OF DISC DEGENERATIVE DISEASE

 

15

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P00l 9US   United States of America   17/052845   11/4/2020       INTRADISCAL T- REGULATORY CELL ADMINISTRATTON FOR TREATMENT OF DISC DEGENERATIVE DISEASE
                     
AMTK.P0019US.P I   United States of America   62/666807   5/4/2018      

INTRADISCAL T REGULATORY CELL

ADMINISTRATION FOR TREATMENT OF DISC DEGENERATIVE

DISEASE

                     
AMTK.P0019WO   Patent Cooperation Treaty   PCT/US2019/030564   5/3/2019       TNTRADISCAL T- REGULATORY CELL ADMINISTRATION FOR TREATMENT OF DISC DEGENERATJVE DISEASE
                     
AMTK.P0020EP   European Patent Office   19796689.8   11/24/2020       ENHANCEMENT OF FIBROBLAST PLASTICITY FOR TREATMENT OF DISC DEGENERATJON
                     
AMTK.P0020US   United States of America   17/052854   11/4/2020       ENHANCEMENT OF FIBROBLAST PLASTICITY FOR TREATMENT OF DISC DEGENERATION
                     
AMTK.P0020US.Pl   United States of America   62/666816   5/4/2018       ENHANCEMENT OF FTBROBLAST PLASTICITY FOR TREATMENT OF DISC DEGENERATION
                     
AMTK.P0020WO   Patent Cooperation Treaty   PCT/US2019/030577   5/3/2019       ENHANCEMENT OF FIBROBLAST PLASTICITY FOR TREATMENT OF DISC DEGENERATTON
                     
AMTK.P0025AU   Australia   2019332928   3/11/2021       CHIMERIC ANTIGEN RECEPTOR FIBROBLAST CELLS FOR TREATMENT OF CANCER
                     
AMTK.P0025CA   Canada   3111213   2/26/2021       CHIMERIC ANTIGEN RECEPTOR FIBROBLAST CELLS FOR TREATMENT OF CANCER

 

16

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0025EP   European Patent Office   19853816.7   3/24/2021       CHIMERIC ANTIGEN RECEPTOR FIBROBLAST CELLS FOR TREATMENT OF CANCER
                     
AMTK.P0025US   United States of America   17/271529   2/25/2021       Cl-HMERIC A TIGEN RECEPTOR FIBROBLAST CELLS FOR TREATMENT OF CANCER
                     
AMTK.P0025US.P I   United States of America   62/723105   8/27/2018       CHIMERIC ANTIGEN RECEPTOR FIBROBLAST CELLS FOR TREATMENT OF CANCER
                     
AMTK.P0025US.P2   United States of America   62/820636   3/19/2019       CHIMERIC ANTIGEN RECEPTOR FIBROBLAST CELLS FOR TREATMENT OF CANCER
                     
AMTK.P0025WO   Patent Cooperation Treaty   PCT/US2019/048311   8/27/2019       CHIMERIC ANTIGEN RECEPTOR FIBROBLAST CELLS FOR TREATMENT OF CANCER
                     
AMTK.P0033US.PJ   United States of America   62/793545   1/17/2019       FIBROBLASTS AND MACROVESICLES THEREOF FOR REDUCTION OF TOXICITY ASSOCIATED WITH CANCER INNUMOTHERAPY
                     
AMTK.P0033WO   Patent Cooperation Treaty   PCT/US2020/014018   1/17/2020       FIBROBLASTS AND MICROVESICLES THEREOFFOR REDUCTION OF TOXICITY ASSOCIATED WITH CANCER INNUMOTHERAPY
                     
AMTK.P0039US.P1   United States of America   62/839716   4/28/2019       FIBROBLAST CELL THERAPY FOR TREATMENT OF OSTEOPOROSIS
                     
AMTK.P0039WO   Patent Cooperation Treaty   PCT/US2020/030063   4/27/2020       FIBROBLAST CELL THERAPY FOR TREATMENT OF OSTEOPOROSIS
                     
AMTK.P0041US.PI   United States of America   62/929828   1 l/2/20 I9       FIBROBLAST-DERIVED UNIVERSAL IMMUNOLOGICAL COMPOSITION

 

17

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0041 WO   Patent Cooperation Treaty   PCT/US2020/058492   11/2/2020       FIBROBLAST-DERIVED UNIVERSAL IMMUNOLOGICAL COMPOSITION
                     
AMTK.P0042US   United States of America   17/022897   9/16/2020       TREATMENT OF DISC DEGENERATIVE DISEASE AND STIMULATION OF PROTEOGLYCAN SYNTHESIS BY FIBROBLAST CONDITIONED MEDIA AND FORMULATIONS THEREOF
                     
AMTK.P0042US.P I   United States of America   62/901164   9/16/2019       TREATMENT OF DISC DEGENERATIVE DISEASE AND STIMULATION OF PROTEOGLYCAN SYNTHESIS BY FIBROBLAST CONDITIONED MEDIA AND FORMULATIONS THEREOF
                     
AMTK.P0042WO   Patent Cooperation Treaty   PCT/US2020/05l 036   9/16/2020       TREATMENT OF DISC DEGENERATIVE DISEASE AND STIMULATION OF PROTEOGLYCAN SYNTHESIS BY FIBROBLAST CONDITIONED MEDIA AND FORMULATIONS THEREOF
                     
AMTK.P0044US.PI   United States of America   62/929830   11/2/2019       INTRATUMORAL ADMINISTRATION OF IMMUNE CELLULAR THERAPEUTICS
                     
AMTK.P0044 WO   Patent Cooperation Treaty   PCT/US2020/058497   11/2/2020       INTRATUMORAL ADMINISTRATION OF IMMUNE CELLULAR THERAPEUTICS
                     
AMTK.P0045US.PI   United States of America               FIBROBLAST DELIVERY OF HYPERACUTE REJECTION INDUCING PAYLOAD TO CANCER CELLS

 

18

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P0048US.PI   United States of America   62/953841   12/26/2019       AUGMENTATION OF FIBROBLAST MEDIATED REGENERATION OF INTRA VERTEBRAL DISCS
                     
AMTK.P0048WO   Patent Cooperation Treaty   PCT/US2020/067225   12/28/2020       AUGMENTATION OF FIBROBLAST MEDIATED REGENERATION OF INTRAVERTEBRAL DISCS
                     
AMTK.P0054US.PI   United States of America   62/914523   10/13/2019       CANNABTDIOL ADJUVANT THERAPY FOR TREATMENT OF DISC DEGENERATIVE DISEASE
                     
AMTK.P0054WO   Patent Cooperation Treaty   PCT/US2020/0553 I3   10/13/2020      

CANNABIDIOL

ADJUVANT THERAPY FOR TREATMENT OF DISC DEGENERATIVE DISEASE

                     
AMTK.P0055US   United States of America   16887720   5/29/2020      

CONCURRENT ACTIVATION OF REGENERATIVE AND TOLEROGENJC PROCESSES BY FIBROBLAST-BASED COMPOSITIONS FOR THE TREATMENT OF

MULTIPLE SCLEROSIS

                     
AMTK.P0055US.PI   United States of America   62855010   5/31/2019      

CONCURRENT ACTIVATION OF REGENERATIVE AND TOLEROGENJC PROCESSES BY FIBROBLAST-BASED COMPOSITIONS FOR THE TREATMENT OF

MULTIPLE SCLEROSIS

                     
AMTK.P0055WO   Patent Cooperation Treaty   PCT/US2020/035234   5/29/2020      

CONCURRENT ACTIVATION OF REGENERATIVE AND TOLEROGENIC PROCESSES BY FIBROBLAST-BASED COMPOSITIONS FOR THE TREATMENT OF

MULTIPLE SCLEROSIS

 

19

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
AMTK.P006 I US.PI   United States of America   62/977604   2/17/2020       TELOMERE LENGTH MODULATION USING FIBROBLASTS AND DERJVITAVES THEREOF
                     
AMTK.P006 J WO  

Patent

Cooperation Treaty

   PCT/US2021/018160   2/16/2021      

TELOMERE LENGTH

MODULATTON USING FIBROBLASTS

                     
AMTK.P0074US.PI   United States of America   63/017918   4/30/2020       IMMUNOTHERAPEUTIC METHODSAND COMPOSITIONS FOR TARGETING CANCER FLBROBLASTS
                     
AMTK.P0074 WO   Patent Cooperation Treaty   PCT/US202 l/070496   4/30/2021       IMMUNOTHERAPEUTIC METHODS AND COMPOSITIONS FOR TARGETING CANCER FIBROBLASTS
                     
AMTK.P0077US.PI   United States of America       Closed duplicate case       CANCER FIBROBLAST SPECIFIC CANCER IMMUNOTHERAPY
                     
P03351AU0   Australia   2007212085   7/29/2008   2007212085   METHODSAND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
P03351CA0   Canada   2641170   7/25/2008   2641170   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
P03351CN0   China   200780004506.8   7/31/2008   ZL 200780004506.8   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
P03351EP0   European Patent Office   07763383.2   9/2/2008   1989289   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
P0335!HK0   Hong Kong   09104307.l   5/11/2009   HKI125406   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR

 

20

 

 

Docket Number   Country   Appl. No.   Date Filed   Reg. No.   Title
                     
P03351IN0   India   6901/DELNP/2008   8/12/2008      

METHODS AND COMPOSJTIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR

                     
P03351JP0   Japan   2008-554464   8/6/2008   5269612   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
P03351US0   United States of America   60/771172   2/7/2006       METHODFOR REPAIRING AN INTERVERTEBRAL DISC
                     
P03351USI   United States of America   11/671082   2/5/2007   7850983   METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
                     
P03351WO0   Patent Cooperation Treaty   PCT/US2007/06l 590   2/5/2007       METHODSAND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR

 

[End of Schedule A.}

 

21