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                             June 17, 2024

       Pete O   Heeron
       Chief Executive Officer
       FibroBiologics, Inc.
       455 E. Medical Center Blvd., Suite 300
       Houston, TX 77598

                                                        Re: FibroBiologics,
Inc.
                                                            Draft Registration
Statement on Form S-1
                                                            Submitted June 10,
2024
                                                            CIK No. 0001958777

       Dear Pete O   Heeron:

                                                        This is to advise you
that we do not intend to review your registration statement.

               We request that you publicly file your registration statement no
later than 48 hours prior
       to the requested effective date and time. Please refer to Rules 460 and
461 regarding requests for
       acceleration. We remind you that the company and its management are
responsible for the
       accuracy and adequacy of their disclosures, notwithstanding any review,
comments, action or
       absence of action by the staff.

                                                        Please contact Doris
Stacey Gama at 202-551-3188 with any questions.




                             Sincerely,


                             Division of Corporation Finance

                             Office of Life Sciences
       cc:                                              Brian P. Fenske, Esq.