Exhibit 107

CALCULATION OF FILING FEE TABLES(1)

424(b)(5)

(Form Type)

ZYMEWORKS INC.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered and Carry Forward Securities

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial Effective Date

Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward

Newly Registered Securities

Fees to Be Paid

Carry Forward Securities

Carry Forward Securities

Equity

Common Stock, $0.00001 par value per share

415(a)(6)

—

$122,798,000 (2)

POSASR

333-259970-01

October 1, 2021

$13,532.34 (4)

Equity

Common Stock, $0.00001 par value per share

415(a)(6)

—

$27,202,000 (3)

POSASR

333-259970-01

October 1, 2021

$2,997.66 (4)

Total Offering Amounts

$150,000,000

—

Total Fees Previously Paid

—

Total Fee Offsets

—

Net Fee Due

—

(1) These “Calculation of Filing Fee Tables” shall be deemed to update the “Calculation of Filing Fee Tables” table in the registrant’s Registration Statement on Form S-3ASR (File No. 333-279073), which was filed on May 2, 2024. The prospectus to which this Exhibit is attached is a final prospectus supplement for the related offering.

(2) On March 7, 2023, the registrant filed Post-Effective Amendment No. 2 and Post-Effective Amendment No. 3 to the Registration Statement on Form S-3 (File No. 333-259970-01) (the “Prior Registration Statement”). Pursuant to Rule 415(a)(6) under the Securities Act, the securities registered herein include $122,798,000 of shares of common stock previously registered by the registrant on the Prior Registration Statement and which remain unsold.

(3) Pursuant to Rule 415(a)(6) under the Securities Act, the securities registered herein include $27,202,000 of shares of common stock previously registered by the registrant as “Unallocated (Universal) Shelf” on the Prior Registration Statement and which remain unsold.

(4) The filing fee paid in connection with the registration of the unsold securities referenced in notes (2) and (3) above in the Prior Registration Statement will continue to be applied to such securities. Accordingly, there is no additional registration fee due in connection with the filing of this prospectus supplement.