The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AMAZON.COM INC Common Stock 023135106   14,336,112 170,668 SH   SOLE   170,668 0 0
MICROSOFT CORP Common Stock 594918104   13,202,091 55,050 SH   SOLE   55,050 0 0
IQIYI INC-ADR ADR 46267X108   12,818,050 2,418,500 SH   SOLE   2,418,500 0 0
PINDUODUO ADR ADR 722304102   10,702,622 131,240 SH   SOLE   131,240 0 0
UNITEDHEALTH Common Stock 91324P102   7,454,861 14,061 SH   SOLE   14,061 0 0
MERCK & CO. INC. Common Stock 58933Y105   7,221,031 64,764 SH   SOLE   64,764 0 0
VISA INC-CLASS A SHARES Common Stock 92826C839   5,910,772 28,450 SH   SOLE   28,450 0 0
SERVICENOW INC Common Stock 81762P102   5,765,810 14,850 SH   SOLE   14,850 0 0
ANALOG DEVICES INC Common Stock 032654105   5,495,005 33,500 SH   SOLE   33,500 0 0
ELI LILLY & CO Common Stock 532457108   5,328,460 14,565 SH   SOLE   14,565 0 0
VERTEX PHARMACEUTICALS INC Common Stock 92532F100   4,847,461 16,786 SH   SOLE   16,786 0 0
APPLE INC Common Stock 037833100   4,235,718 32,600 SH   SOLE   32,600 0 0
WORKDAY INC-CLASS A Common Stock 98138H101   3,831,857 22,900 SH   SOLE   22,900 0 0
COSTCO WHOLESALE CORP Common Stock 22160K105   3,756,082 8,228 SH   SOLE   8,228 0 0
ON SEMICONDUCTOR Common Stock 682189105   3,742,200 60,000 SH   SOLE   60,000 0 0
ALPHABET INC-CL A Common Stock 02079K305   3,423,324 38,800 SH   SOLE   38,800 0 0
DEXCOM INC Common Stock 252131107   3,415,205 30,159 SH   SOLE   30,159 0 0
RAMBUS INC Common Stock 750917106   3,331,260 93,000 SH   SOLE   93,000 0 0
LULULEMON ATHLETICA INC Common Stock 550021109   3,315,292 10,348 SH   SOLE   10,348 0 0
HOME DEPOT INC Common Stock 437076102   3,235,670 10,244 SH   SOLE   10,244 0 0
ALNYLAM PHARMACEUTICALS INC Common Stock 02043Q107   3,232,991 13,604 SH   SOLE   13,604 0 0
FORTINET INC Common Stock 34959E109   3,177,850 65,000 SH   SOLE   65,000 0 0
WOLFSPEED INC Common Stock 977852102   3,132,276 45,369 SH   SOLE   45,369 0 0
UNIQURE NV Common Stock N90064101   3,014,657 132,980 SH   SOLE   132,980 0 0
KEYSIGHT TECHNOLOGIES IN Common Stock 49338L103   2,993,725 17,500 SH   SOLE   17,500 0 0
ADOBE SYSTEMS INC Common Stock 00724F101   2,961,464 8,800 SH   SOLE   8,800 0 0
BIONTECH SE-ADR ADR 09075V102   2,863,944 19,065 SH   SOLE   19,065 0 0
TAIWAN SEMICONDUCTOR-SP ADR ADR 874039100   2,860,563 38,200 SH   SOLE   38,200 0 0
SALESFORCE INC Common Stock 79466L302   2,771,131 20,900 SH   SOLE   20,900 0 0
MARVELL TECHNOLOGY GROUP LTD Common Stock 573874104   2,722,440 73,500 SH   SOLE   73,500 0 0
BROADCOM LTD Common Stock 11135F101   2,711,781 4,850 SH   SOLE   4,850 0 0
BIOMARIN PHARMACEUTICAL INC Common Stock 09061G101   2,683,496 25,930 SH   SOLE   25,930 0 0
INTUITIVE SURGICAL INC Common Stock 46120E602   2,546,033 9,595 SH   SOLE   9,595 0 0
ISHARES GOLD TRUST ETP 464285204   2,525,070 73,000 SH   SOLE   73,000 0 0
PALO ALTO NETWORKS INC Common Stock 697435105   2,511,720 18,000 SH   SOLE   18,000 0 0
CATALENT INC Common Stock 148806102   2,508,092 55,723 SH   SOLE   55,723 0 0
SPDR GOLD SHARES ETP 78463V107   2,493,708 14,700 SH   SOLE   14,700 0 0
ASML HOLDING NV-NY REG SHS NY Reg Shrs N07059210   2,458,800 4,500 SH   SOLE   4,500 0 0
abrdn Gold ETF Trust ETP 00326A104   2,445,800 140,000 SH   SOLE   140,000 0 0
MASTERCARD INC - A Common Stock 57636Q104   2,434,110 7,000 SH   SOLE   7,000 0 0
AUTODESK INC Common Stock 052769106   2,233,097 11,950 SH   SOLE   11,950 0 0
UBER TECHNOLOGIES INC Common Stock 90353T100   2,225,700 90,000 SH   SOLE   90,000 0 0
AIRBNB INC-CLASS A Common Stock 009066101   2,166,399 25,338 SH   SOLE   25,338 0 0
DOORDASH INC - A Common Stock 25809K105   2,041,848 41,824 SH   SOLE   41,824 0 0
TESLA INC Common Stock 88160R101   2,011,653 16,331 SH   SOLE   16,331 0 0
Meta Platforms Inc. Common Stock 30303M102   2,002,939 16,644 SH   SOLE   16,644 0 0
TOWER SEMICONDUCTOR LTD Common Stock M87915274   1,944,000 45,000 SH   SOLE   45,000 0 0
SYNOPSYS INC Common Stock 871607107   1,915,740 6,000 SH   SOLE   6,000 0 0
NVIDIA CORP Common Stock 67066G104   1,914,434 13,100 SH   SOLE   13,100 0 0
CROWDSTRIKE HOLDINGS INC - A Common Stock 22788C105   1,758,343 16,700 SH   SOLE   16,700 0 0
ADVANCED MICRO DEVICES Common Stock 007903107   1,735,836 26,800 SH   SOLE   26,800 0 0
ATLASSIAN CORP PLC-CLASS A Common Stock 049468101   1,711,444 13,300 SH   SOLE   13,300 0 0
MODERNA INC Common Stock 60770K107   1,704,414 9,489 SH   SOLE   9,489 0 0
BATH & BODY WORKS INC Common Stock 070830104   1,567,861 37,206 SH   SOLE   37,206 0 0
NOVO-NORDISK A/S-SPONS ADR ADR 670100205   1,548,290 11,440 SH   SOLE   11,440 0 0
KE HOLDINGS INC ADR 482497104   1,469,988 105,300 SH   SOLE   105,300 0 0
ALBEMARLE CORP Common Stock 012653101   1,456,055 6,700 SH   SOLE   6,700 0 0
SPDR S&P BIOTECH ETF ETP 78464A870   1,405,771 16,937 SH   SOLE   16,937 0 0
BIOGEN INC Common Stock 09062X103   1,232,848 4,452 SH   SOLE   4,452 0 0
Block Inc Common Stock 852234103   1,231,664 19,600 SH   SOLE   19,600 0 0
HALOZYME THERAPEUTICS INC Common Stock 40637H109   1,231,088 21,636 SH   SOLE   21,636 0 0
LI AUTO INC - ADR ADR 50202M102   1,122,000 55,000 SH   SOLE   55,000 0 0
DECKERS OUTDOOR CORP Common Stock 243537107   929,644 2,329 SH   SOLE   2,329 0 0
TARGET CORP Common Stock 87612E106   924,644 6,204 SH   SOLE   6,204 0 0
BOOKING HOLDINGS INC Common Stock 09857L108   912,922 453 SH   SOLE   453 0 0
NIKE INC -CL B Common Stock 654106103   910,221 7,779 SH   SOLE   7,779 0 0
DINGDONG CAYMAN LTD -SPN ADR ADR 25445D101   901,457 211,114 SH   SOLE   211,114 0 0
IDEXX LABORATORIES INC Common Stock 45168D104   893,432 2,190 SH   SOLE   2,190 0 0
GILEAD SCIENCES INC Common Stock 375558103   866,141 10,089 SH   SOLE   10,089 0 0
H World Group Ltd ADR 44332N106   861,126 20,300 SH   SOLE   20,300 0 0
On Holding AG Common Stock H5919C104   848,459 49,444 SH   SOLE   49,444 0 0
AMGEN INC Common Stock 031162100   812,608 3,094 SH   SOLE   3,094 0 0
WALT DISNEY CO/THE Common Stock 254687106   812,067 9,347 SH   SOLE   9,347 0 0
ILLUMINA INC Common Stock 452327109   801,521 3,964 SH   SOLE   3,964 0 0
ULTA BEAUTY INC Common Stock 90384S303   789,914 1,684 SH   SOLE   1,684 0 0
REGENERON PHARMACEUTICALS Common Stock 75886F107   784,981 1,088 SH   SOLE   1,088 0 0
DANAHER CORP Common Stock 235851102   781,793 2,943 SH   SOLE   2,943 0 0
DOLLAR TREE INC Common Stock 256746108   733,366 5,185 SH   SOLE   5,185 0 0
SHOPIFY INC - CLASS A Common Stock 82509L107   708,952 20,425 SH   SOLE   20,425 0 0
NEW ORIENTAL EDUCATION-SP ADR ADR 647581206   685,014 19,673 SH   SOLE   19,673 0 0
SKECHERS USA INC-CL A Common Stock 830566105   682,652 16,273 SH   SOLE   16,273 0 0
GENERAL MOTORS CO Common Stock 37045V100   672,800 20,000 SH   SOLE   20,000 0 0
CHARGEPOINT HOLDINGS INC Common Stock 15961R105   667,100 70,000 SH   SOLE   70,000 0 0
DOCUSIGN INC Common Stock 256163106   554,200 10,000 SH   SOLE   10,000 0 0
QUALCOMM INC Common Stock 747525103   549,700 5,000 SH   SOLE   5,000 0 0
FULL TRUCK ALLIANCE ADR 35969L108   544,800 68,100 SH   SOLE   68,100 0 0
REPLIGEN CORP Common Stock 759916109   500,480 2,956 SH   SOLE   2,956 0 0
FERRARI NV Common Stock N3167Y103   428,440 2,000 SH   SOLE   2,000 0 0
ASTRAZENECA PLC-SPONS ADR ADR 046353108   420,835 6,207 SH   SOLE   6,207 0 0
Trip.com Grp Ltd ADR 89677Q107   409,360 11,900 SH   SOLE   11,900 0 0
BILIBILI INC-SPONSORED ADR ADR 090040106   404,483 17,074 SH   SOLE   17,074 0 0
HILTON WORLDWIDE HOLDINGS IN Common Stock 43300A203   377,437 2,987 SH   SOLE   2,987 0 0
UNITY SOFTWARE INC Common Stock 91332U101   373,042 13,048 SH   SOLE   13,048 0 0
CAPRI HOLDINGS LTD Common Stock G1890L107   343,175 5,987 SH   SOLE   5,987 0 0
STAAR SURGICAL CO Common Stock 852312305   330,218 6,803 SH   SOLE   6,803 0 0
ALPHABET INC-CL C Common Stock 02079K107   317,121 3,574 SH   SOLE   3,574 0 0
EURONAV NV Common Stock B38564108   272,640 16,000 SH   SOLE   16,000 0 0
HORIZON THERAPEUTICS PLC Common Stock G46188101   261,968 2,302 SH   SOLE   2,302 0 0
DOMINO'S PIZZA INC Common Stock 25754A201   255,990 739 SH   SOLE   739 0 0
ROBLOX CORP -CLASS A Common Stock 771049103   255,002 8,960 SH   SOLE   8,960 0 0
CANADA GOOSE HOLDINGS INC Common Stock 135086106   251,121 14,100 SH   SOLE   14,100 0 0
SEAGEN INC Common Stock 81181C104   242,370 1,886 SH   SOLE   1,886 0 0
AUTOLIV INC Common Stock 052800109   229,740 3,000 SH   SOLE   3,000 0 0
ROSS STORES INC Common Stock 778296103   206,024 1,775 SH   SOLE   1,775 0 0
RALPH LAUREN CORP Common Stock 751212101   188,869 1,776 SH   SOLE   1,776 0 0
INCYTE CORP Common Stock 45337C102   181,523 2,260 SH   SOLE   2,260 0 0
ROYALTY PHARMA PLC- CL A Common Stock G7709Q104   177,089 4,481 SH   SOLE   4,481 0 0
ZOOM VIDEO COMMUNICATIONS-A Common Stock 98980L101   165,286 2,440 SH   SOLE   2,440 0 0
CRISPR THERAPEUTICS AG Common Stock H17182108   146,259 3,598 SH   SOLE   3,598 0 0
ZOETIS INC Common Stock 98978V103   144,498 986 SH   SOLE   986 0 0
SANOFI-ADR ADR 80105N105   142,142 2,935 SH   SOLE   2,935 0 0
MELCO RESORTS & ENTERT-ADR ADR 585464100   141,450 12,300 SH   SOLE   12,300 0 0
VIATRIS INC Common Stock 92556V106   137,122 12,320 SH   SOLE   12,320 0 0
PACIFIC BIOSCIENCES OF CALIF Common Stock 69404D108   131,698 16,100 SH   SOLE   16,100 0 0
UNITED THERAPEUTICS CORP Common Stock 91307C102   128,756 463 SH   SOLE   463 0 0
ARGENX SE - ADR ADR 04016X101   119,710 316 SH   SOLE   316 0 0
NEUROCRINE BIOSCIENCES INC Common Stock 64125C109   116,693 977 SH   SOLE   977 0 0
SAREPTA THERAPEUTICS INC Common Stock 803607100   115,585 892 SH   SOLE   892 0 0
CHIPOTLE MEXICAN GRILL INC Common Stock 169656105   112,387 81 SH   SOLE   81 0 0
BEIGENE LTD-ADR ADR 07725L102   106,891 486 SH   SOLE   486 0 0
CVS HEALTH CORP Common Stock 126650100   103,907 1,115 SH   SOLE   1,115 0 0
JAZZ PHARMACEUTICALS PLC Common Stock G50871105   101,799 639 SH   SOLE   639 0 0
ALIGN TECHNOLOGY INC Common Stock 016255101   91,742 435 SH   SOLE   435 0 0
AMBARELLA INC Common Stock G037AX101   82,230 1,000 SH   SOLE   1,000 0 0
ALIBABA GROUP HOLDING LTD ADR 01609W102   81,043 920 SH   SOLE   920 0 0
NOVOCURE LTD Common Stock G6674U108   78,191 1,066 SH   SOLE   1,066 0 0
CARNIVAL CORP Common Stock 143658300   77,215 9,580 SH   SOLE   9,580 0 0
AMPHENOL CORP-CL A Common Stock 032095101   76,329 1,000 SH   SOLE   1,000 0 0
ASCENDIS PHARMA A/S - ADR ADR 04351P101   69,248 567 SH   SOLE   567 0 0
KARUNA THERAPEUTICS INC Common Stock 48576A100   68,579 349 SH   SOLE   349 0 0
MEDPACE HOLDINGS INC Common Stock 58506Q109   67,122 316 SH   SOLE   316 0 0
GUARDANT HEALTH INC Common Stock 40131M109   66,259 2,436 SH   SOLE   2,436 0 0
ROIVANT SCIENCES LTD Common Stock G76279101   58,878 7,369 SH   SOLE   7,369 0 0
APELLIS PHARMACEUTICALS INC Common Stock 03753U106   58,070 1,123 SH   SOLE   1,123 0 0
IONIS PHARMACEUTICALS INC Common Stock 462222100   54,502 1,443 SH   SOLE   1,443 0 0
EXELIXIS INC Common Stock 30161Q104   52,563 3,277 SH   SOLE   3,277 0 0
INTRA-CELLULAR THERAPIES INC Common Stock 46116X101   50,909 962 SH   SOLE   962 0 0
MADRIGAL PHARMACEUTICALS INC Common Stock 558868105   50,504 174 SH   SOLE   174 0 0
PROMETHEUS BIOSCIENCES INC Common Stock 74349U108   46,860 426 SH   SOLE   426 0 0
ALKERMES PLC Common Stock G01767105   43,611 1,669 SH   SOLE   1,669 0 0
ARROWHEAD PHARMACEUTICALS IN Common Stock 04280A100   43,683 1,077 SH   SOLE   1,077 0 0
CYTOKINETICS INC Common Stock 23282W605   44,033 961 SH   SOLE   961 0 0
ZTO EXPRESS CAYMAN INC-ADR ADR 98980A105   42,992 1,600 SH   SOLE   1,600 0 0
VAXCYTE INC Common Stock 92243G108   38,504 803 SH   SOLE   803 0 0
DENALI THERAPEUTICS INC Common Stock 24823R105   38,378 1,380 SH   SOLE   1,380 0 0
SYNEOS HEALTH INC Common Stock 87166B102   38,331 1,045 SH   SOLE   1,045 0 0
BEAM THERAPEUTICS INC Common Stock 07373V105   37,233 952 SH   SOLE   952 0 0
AMICUS THERAPEUTICS INC Common Stock 03152W109   34,847 2,854 SH   SOLE   2,854 0 0
AXSOME THERAPEUTICS INC Common Stock 05464T104   34,014 441 SH   SOLE   441 0 0
VIR BIOTECHNOLOGY INC Common Stock 92764N102   34,244 1,353 SH   SOLE   1,353 0 0
INTELLIA THERAPEUTICS INC Common Stock 45826J105   33,285 954 SH   SOLE   954 0 0
HARMONY BIOSCIENCES HOLDINGS Common Stock 413197104   33,225 603 SH   SOLE   603 0 0
LEGEND BIOTECH CORP-ADR ADR 52490G102   32,847 658 SH   SOLE   658 0 0
ULTRAGENYX PHARMACEUTICAL IN Common Stock 90400D108   32,987 712 SH   SOLE   712 0 0
PROTHENA CORP PLC Common Stock G72800108   29,583 491 SH   SOLE   491 0 0
ABCELLERA BIOLOGICS INC Common Stock 00288U106   29,438 2,906 SH   SOLE   2,906 0 0
PTC THERAPEUTICS INC Common Stock 69366J200   27,902 731 SH   SOLE   731 0 0
BLUEPRINT MEDICINES CORP Common Stock 09627Y109   26,636 608 SH   SOLE   608 0 0
INSMED INC Common Stock 457669307   27,492 1,376 SH   SOLE   1,376 0 0
MIRATI THERAPEUTICS INC Common Stock 60468T105   26,506 585 SH   SOLE   585 0 0
ACADIA PHARMACEUTICALS INC Common Stock 004225108   26,188 1,645 SH   SOLE   1,645 0 0
AKERO THERAPEUTICS INC Common Stock 00973Y108   26,030 475 SH   SOLE   475 0 0
IVERIC BIO INC Common Stock 46583P102   26,270 1,227 SH   SOLE   1,227 0 0
AMYLYX PHARMACEUTICALS INC Common Stock 03237H101   24,867 673 SH   SOLE   673 0 0
XENON PHARMACEUTICALS INC Common Stock 98420N105   25,038 635 SH   SOLE   635 0 0
IMMUNOVANT INC Common Stock 45258J102   23,288 1,312 SH   SOLE   1,312 0 0
SAGE THERAPEUTICS INC Common Stock 78667J108   23,075 605 SH   SOLE   605 0 0
BIOCRYST PHARMACEUTICALS INC Common Stock 09058V103   21,732 1,893 SH   SOLE   1,893 0 0
ZAI LAB LTD-ADR ADR 98887Q104   21,521 701 SH   SOLE   701 0 0
IMMUNITYBIO INC Common Stock 45256X103   20,620 4,067 SH   SOLE   4,067 0 0
KRYSTAL BIOTECH INC Common Stock 501147102   20,756 262 SH   SOLE   262 0 0
REVOLUTION MEDICINES INC Common Stock 76155X100   21,486 902 SH   SOLE   902 0 0
SUPERNUS PHARMACEUTICALS INC Common Stock 868459108   19,583 549 SH   SOLE   549 0 0
CHARLES RIVER LABORATORIES Common Stock 159864107   19,393 89 SH   SOLE   89 0 0
EDWARDS LIFESCIENCES CORP Common Stock 28176E108   19,100 256 SH   SOLE   256 0 0
ARVINAS INC Common Stock 04335A105   18,508 541 SH   SOLE   541 0 0
IRONWOOD PHARMACEUTICALS INC Common Stock 46333X108   19,304 1,558 SH   SOLE   1,558 0 0
MARAVAI LIFESCIENCES HLDGS-A Common Stock 56600D107   19,118 1,336 SH   SOLE   1,336 0 0
VENTYX BIOSCIENCES INC Common Stock 92332V107   18,854 575 SH   SOLE   575 0 0
GENMAB A/S -SP ADR ADR 372303206   18,393 434 SH   SOLE   434 0 0
PACIRA BIOSCIENCES INC Common Stock 695127100   17,992 466 SH   SOLE   466 0 0
RELAY THERAPEUTICS INC Common Stock 75943R102   18,346 1,228 SH   SOLE   1,228 0 0
IQVIA HOLDINGS INC Common Stock 46266C105   17,211 84 SH   SOLE   84 0 0
CHINOOK THERAPEUTICS INC Common Stock 16961L106   17,004 649 SH   SOLE   649 0 0
RHYTHM PHARMACEUTICALS INC Common Stock 76243J105   16,657 572 SH   SOLE   572 0 0
VERACYTE INC Common Stock 92337F107   17,299 729 SH   SOLE   729 0 0
AGIOS PHARMACEUTICALS INC Common Stock 00847X104   15,669 558 SH   SOLE   558 0 0
DAY ONE BIOPHARMACEUTICALS I Common Stock 23954D109   16,075 747 SH   SOLE   747 0 0
SYNDAX PHARMACEUTICALS INC Common Stock 87164F105   15,575 612 SH   SOLE   612 0 0
SPRINGWORKS THERAPEUTICS INC Common Stock 85205L107   16,490 634 SH   SOLE   634 0 0
VERONA PHARMA PLC - ADR ADR 925050106   16,122 617 SH   SOLE   617 0 0
XENCOR INC Common Stock 98401F105   15,858 609 SH   SOLE   609 0 0
DICE THERAPEUTICS INC Common Stock 23345J104   15,101 484 SH   SOLE   484 0 0
FIBROGEN INC Common Stock 31572Q808   15,299 955 SH   SOLE   955 0 0
IMMUNOCORE HOLDINGS PLC-ADR ADR 45258D105   14,952 262 SH   SOLE   262 0 0
NUVALENT INC-A Common Stock 670703107   15,426 518 SH   SOLE   518 0 0
ROCKET PHARMACEUTICALS INC Common Stock 77313F106   15,049 769 SH   SOLE   769 0 0
REVANCE THERAPEUTICS INC Common Stock 761330109   15,433 836 SH   SOLE   836 0 0
ARCELLX INC Common Stock 03940C100   13,786 445 SH   SOLE   445 0 0
AMPHASTAR PHARMACEUTICALS IN Common Stock 03209R103   13,758 491 SH   SOLE   491 0 0
KYMERA THERAPEUTICS INC Common Stock 501575104   13,903 557 SH   SOLE   557 0 0
MANNKIND CORP Common Stock 56400P706   14,092 2,674 SH   SOLE   2,674 0 0
REPLIMUNE GROUP INC Common Stock 76029N106   13,736 505 SH   SOLE   505 0 0
RECURSION PHARMACEUTICALS-A Common Stock 75629V104   14,233 1,846 SH   SOLE   1,846 0 0
TRAVERE THERAPEUTICS INC Common Stock 89422G107   13,712 652 SH   SOLE   652 0 0
TWIST BIOSCIENCE CORP Common Stock 90184D100   13,667 574 SH   SOLE   574 0 0
KEROS THERAPEUTICS INC Common Stock 492327101   13,446 280 SH   SOLE   280 0 0
BRIDGEBIO PHARMA INC Common Stock 10806X102   11,575 1,519 SH   SOLE   1,519 0 0
CUREVAC NV Common Stock N2451R105   11,656 1,933 SH   SOLE   1,933 0 0
EQRX INC Common Stock 26886C107   12,207 4,962 SH   SOLE   4,962 0 0
MYRIAD GENETICS INC Common Stock 62855J104   11,942 823 SH   SOLE   823 0 0
REATA PHARMACEUTICALS INC-A Common Stock 75615P103   12,271 323 SH   SOLE   323 0 0
AVIDITY BIOSCIENCES INC Common Stock 05370A108   12,271 553 SH   SOLE   553 0 0
VERVE THERAPEUTICS INC Common Stock 92539P101   12,113 626 SH   SOLE   626 0 0
ZENTALIS PHARMACEUTICALS INC Common Stock 98943L107   11,661 579 SH   SOLE   579 0 0
JD.COM INC-ADR ADR 47215P106   11,226 200 SH   SOLE   200 0 0
ACLARIS THERAPEUTICS INC Common Stock 00461U105   10,679 678 SH   SOLE   678 0 0
ADAPTIVE BIOTECHNOLOGIES Common Stock 00650F109   11,101 1,453 SH   SOLE   1,453 0 0
DECIPHERA PHARMACEUTICALS IN Common Stock 24344T101   11,260 687 SH   SOLE   687 0 0
IMMUNOGEN INC Common Stock 45253H101   11,120 2,242 SH   SOLE   2,242 0 0
INHIBRX INC Common Stock 45720L107   10,891 442 SH   SOLE   442 0 0
LIGAND PHARMACEUTICALS Common Stock 53220K504   11,423 171 SH   SOLE   171 0 0
BELLUS HEALTH INC Common Stock 07987C204   10,497 1,277 SH   SOLE   1,277 0 0
CRINETICS PHARMACEUTICALS IN Common Stock 22663K107   10,010 547 SH   SOLE   547 0 0
ENANTA PHARMACEUTICALS INC Common Stock 29251M106   9,816 211 SH   SOLE   211 0 0
FATE THERAPEUTICS INC Common Stock 31189P102   9,959 987 SH   SOLE   987 0 0
GRIFOLS SA-ADR ADR 398438408   9,597 1,129 SH   SOLE   1,129 0 0
IOVANCE BIOTHERAPEUTICS INC Common Stock 462260100   10,243 1,603 SH   SOLE   1,603 0 0
MORPHIC HOLDING INC Common Stock 61775R105   10,486 392 SH   SOLE   392 0 0
PLIANT THERAPEUTICS INC Common Stock 729139105   9,568 495 SH   SOLE   495 0 0
REGENXBIO INC Common Stock 75901B107   9,957 439 SH   SOLE   439 0 0
NOVAVAX INC Common Stock 670002401   8,779 854 SH   SOLE   854 0 0
VEEVA SYSTEMS INC-CLASS A Common Stock 922475108   8,876 55 SH   SOLE   55 0 0
ALLOGENE THERAPEUTICS INC Common Stock 019770106   9,215 1,465 SH   SOLE   1,465 0 0
ANAPTYSBIO INC Common Stock 032724106   8,956 289 SH   SOLE   289 0 0
ARCUTIS BIOTHERAPEUTICS INC Common Stock 03969K108   9,161 619 SH   SOLE   619 0 0
GERON CORP Common Stock 374163103   9,373 3,873 SH   SOLE   3,873 0 0
IDEAYA BIOSCIENCES INC Common Stock 45166A102   8,885 489 SH   SOLE   489 0 0
INNOVIVA INC Common Stock 45781M101   9,394 709 SH   SOLE   709 0 0
KURA ONCOLOGY INC Common Stock 50127T109   8,600 693 SH   SOLE   693 0 0
LYELL IMMUNOPHARMA INC Common Stock 55083R104   8,790 2,533 SH   SOLE   2,533 0 0
PROVENTION BIO INC Common Stock 74374N102   9,365 886 SH   SOLE   886 0 0
SUMMIT THERAPEUTICS INC Common Stock 86627T108   8,691 2,045 SH   SOLE   2,045 0 0
10X GENOMICS INC-CLASS A Common Stock 88025U109   8,308 228 SH   SOLE   228 0 0
ADMA BIOLOGICS INC Common Stock 000899104   7,756 1,999 SH   SOLE   1,999 0 0
ALECTOR INC Common Stock 014442107   7,753 840 SH   SOLE   840 0 0
ALTIMMUNE INC Common Stock 02155H200   8,209 499 SH   SOLE   499 0 0
BICYCLE THERAPEUTICS PLC-ADR ADR 088786108   7,666 259 SH   SOLE   259 0 0
COGENT BIOSCIENCES INC Common Stock 19240Q201   8,208 710 SH   SOLE   710 0 0
COLLEGIUM PHARMACEUTICAL INC Common Stock 19459J104   7,911 341 SH   SOLE   341 0 0
SANA BIOTECHNOLOGY INC Common Stock 799566104   7,655 1,938 SH   SOLE   1,938 0 0
ARS PHARMACEUTICALS INC Common Stock 82835W108   8,129 953 SH   SOLE   953 0 0
THERAVANCE BIOPHARMA INC Common Stock G8807B106   7,674 684 SH   SOLE   684 0 0
SCHRODINGER INC Common Stock 80810D103   6,542 350 SH   SOLE   350 0 0
DADA NEXUS LTD-ADR ADR 23344D108   6,970 1,000 SH   SOLE   1,000 0 0
ALLAKOS INC Common Stock 01671P100   7,283 865 SH   SOLE   865 0 0
ANI PHARMACEUTICALS INC Common Stock 00182C103   7,161 178 SH   SOLE   178 0 0
ANAVEX LIFE SCIENCES CORP Common Stock 032797300   7,334 792 SH   SOLE   792 0 0
4D MOLECULAR THERAPEUTICS IN Common Stock 35104E100   7,307 329 SH   SOLE   329 0 0
ITEOS THERAPEUTICS INC Common Stock 46565G104   7,050 361 SH   SOLE   361 0 0
SERES THERAPEUTICS INC Common Stock 81750R102   7,084 1,265 SH   SOLE   1,265 0 0
MIRUM PHARMACEUTICALS INC Common Stock 604749101   7,293 374 SH   SOLE   374 0 0
MERUS NV Common Stock N5749R100   7,286 471 SH   SOLE   471 0 0
RAPT THERAPEUTICS INC Common Stock 75382E109   6,831 345 SH   SOLE   345 0 0
EXACT SCIENCES CORP Common Stock 30063P105   6,337 128 SH   SOLE   128 0 0
PROCTER & GAMBLE CO/THE Common Stock 742718109   6,062 40 SH   SOLE   40 0 0
AURINIA PHARMACEUTICALS INC Common Stock 05156V102   6,238 1,444 SH   SOLE   1,444 0 0
BLUEBIRD BIO INC Common Stock 09609G100   5,827 842 SH   SOLE   842 0 0
CARA THERAPEUTICS INC Common Stock 140755109   5,864 546 SH   SOLE   546 0 0
COHERUS BIOSCIENCES INC Common Stock 19249H103   6,257 790 SH   SOLE   790 0 0
CASTLE BIOSCIENCES INC Common Stock 14843C105   6,309 268 SH   SOLE   268 0 0
DESIGN THERAPEUTICS INC Common Stock 25056L103   5,828 568 SH   SOLE   568 0 0
DYNE THERAPEUTICS INC Common Stock 26818M108   6,143 530 SH   SOLE   530 0 0
EDITAS MEDICINE INC Common Stock 28106W103   6,191 698 SH   SOLE   698 0 0
89BIO INC Common Stock 282559103   6,021 473 SH   SOLE   473 0 0
EDGEWISE THERAPEUTICS INC Common Stock 28036F105   5,739 642 SH   SOLE   642 0 0
GALAPAGOS NV-SPON ADR ADR 36315X101   6,036 136 SH   SOLE   136 0 0
HUTCHMED CHINA-ADR ADR 44842L103   5,543 375 SH   SOLE   375 0 0
HILLEVAX INC Common Stock 43157M102   5,671 339 SH   SOLE   339 0 0
23ANDME HOLDING CO -CLASS A Common Stock 90138Q108   6,292 2,913 SH   SOLE   2,913 0 0
MERSANA THERAPEUTICS INC Common Stock 59045L106   5,942 1,014 SH   SOLE   1,014 0 0
MAXCYTE INC Common Stock 57777K106   5,662 1,037 SH   SOLE   1,037 0 0
REPARE THERAPEUTICS INC Common Stock 760273102   6,266 426 SH   SOLE   426 0 0
TANGO THERAPEUTICS INC Common Stock 87583X109   6,496 896 SH   SOLE   896 0 0
WAVE LIFE SCIENCES LTD Common Stock Y95308105   6,181 883 SH   SOLE   883 0 0
NIU TECHNOLOGIES-SPONS ADR ADR 65481N100   5,230 1,000 SH   SOLE   1,000 0 0
ABCAM PLC-SPON ADR ADR 000380204   4,901 315 SH   SOLE   315 0 0
ALLOVIR INC Common Stock 019818103   4,858 947 SH   SOLE   947 0 0
ALX ONCOLOGY HOLDINGS INC Common Stock 00166B105   4,666 414 SH   SOLE   414 0 0
AMARIN CORP PLC -ADR ADR 023111206   4,934 4,078 SH   SOLE   4,078 0 0
ARCTURUS THERAPEUTICS HOLDIN Common Stock 03969T109   4,562 269 SH   SOLE   269 0 0
ARDELYX INC Common Stock 039697107   5,426 1,904 SH   SOLE   1,904 0 0
CYMABAY THERAPEUTICS INC Common Stock 23257D103   5,392 860 SH   SOLE   860 0 0
CULLINAN ONCOLOGY INC Common Stock 230031106   4,906 465 SH   SOLE   465 0 0
CINCOR PHARMA INC Common Stock 17240Y109   5,457 444 SH   SOLE   444 0 0
ERASCA INC Common Stock 29479A108   5,357 1,243 SH   SOLE   1,243 0 0
ESPERION THERAPEUTICS INC Common Stock 29664W105   4,666 749 SH   SOLE   749 0 0
INTERCEPT PHARMACEUTICALS IN Common Stock 45845P108   5,208 421 SH   SOLE   421 0 0
IGM BIOSCIENCES INC Common Stock 449585108   5,035 296 SH   SOLE   296 0 0
KINIKSA PHARMACEUTICALS-A Common Stock G5269C101   5,258 351 SH   SOLE   351 0 0
KEZAR LIFE SCIENCES INC Common Stock 49372L100   4,893 695 SH   SOLE   695 0 0
NURIX THERAPEUTICS INC Common Stock 67080M103   5,259 479 SH   SOLE   479 0 0
PHATHOM PHARMACEUTICALS INC Common Stock 71722W107   4,746 423 SH   SOLE   423 0 0
POSEIDA THERAPEUTICS INC Common Stock 73730P108   4,632 874 SH   SOLE   874 0 0
PROTAGONIST THERAPEUTICS INC Common Stock 74366E102   5,455 500 SH   SOLE   500 0 0
SANGAMO THERAPEUTICS INC Common Stock 800677106   5,228 1,665 SH   SOLE   1,665 0 0
SIGA TECHNOLOGIES INC Common Stock 826917106   5,461 742 SH   SOLE   742 0 0
SCHOLAR ROCK HOLDING CORP Common Stock 80706P103   4,751 525 SH   SOLE   525 0 0
SUTRO BIOPHARMA INC Common Stock 869367102   4,711 583 SH   SOLE   583 0 0
XPENG INC - ADR ADR 98422D105   3,976 400 SH   SOLE   400 0 0
ARBUTUS BIOPHARMA CORP Common Stock 03879J100   3,705 1,590 SH   SOLE   1,590 0 0
ADICET BIO INC Common Stock 007002108   3,889 435 SH   SOLE   435 0 0
ATAI LIFE SCIENCES NV Common Stock N0731H103   4,482 1,685 SH   SOLE   1,685 0 0
AVADEL PHARMACEUTICALS-ADR ADR 05337M104   4,425 618 SH   SOLE   618 0 0
ATEA PHARMACEUTICALS INC Common Stock 04683R106   4,069 846 SH   SOLE   846 0 0
BIOATLA INC Common Stock 09077B104   3,869 469 SH   SOLE   469 0 0
CARIBOU BIOSCIENCES INC Common Stock 142038108   3,894 620 SH   SOLE   620 0 0
EAGLE PHARMACEUTICALS INC Common Stock 269796108   3,858 132 SH   SOLE   132 0 0
EVOLUS INC Common Stock 30052C107   4,288 571 SH   SOLE   571 0 0
FULCRUM THERAPEUTICS INC Common Stock 359616109   3,851 529 SH   SOLE   529 0 0
MONTE ROSA THERAPEUTICS INC Common Stock 61225M102   3,744 492 SH   SOLE   492 0 0
HARROW HEALTH INC Common Stock 415858109   4,103 278 SH   SOLE   278 0 0
INOVIO PHARMACEUTICALS INC Common Stock 45773H201   3,955 2,535 SH   SOLE   2,535 0 0
KODIAK SCIENCES INC Common Stock 50015M109   3,809 532 SH   SOLE   532 0 0
LEXICON PHARMACEUTICALS INC Common Stock 528872302   3,663 1,918 SH   SOLE   1,918 0 0
MACROGENICS INC Common Stock 556099109   4,187 624 SH   SOLE   624 0 0
NGM BIOPHARMACEUTICALS INC Common Stock 62921N105   4,167 830 SH   SOLE   830 0 0
NEKTAR THERAPEUTICS Common Stock 640268108   4,317 1,910 SH   SOLE   1,910 0 0
NANOSTRING TECHNOLOGIES INC Common Stock 63009R109   3,778 474 SH   SOLE   474 0 0
PMV PHARMACEUTICALS INC Common Stock 69353Y103   4,037 464 SH   SOLE   464 0 0
STOKE THERAPEUTICS INC Common Stock 86150R107   3,701 401 SH   SOLE   401 0 0
TARSUS PHARMACEUTICALS INC Common Stock 87650L103   3,973 271 SH   SOLE   271 0 0
TERNS PHARMACEUTICALS INC Common Stock 880881107   3,899 383 SH   SOLE   383 0 0
2SEVENTY BIO INC Common Stock 901384107   3,617 386 SH   SOLE   386 0 0
VANDA PHARMACEUTICALS INC Common Stock 921659108   4,249 575 SH   SOLE   575 0 0
PEPSICO INC Common Stock 713448108   3,211 4 SH   SOLE   4 0 0
STARBUCKS CORP Common Stock 855244109   2,579 26 SH   SOLE   26 0 0
ALPINE IMMUNE SCIENCES INC Common Stock 02083G100   3,432 467 SH   SOLE   467 0 0
ANNEXON INC Common Stock 03589W102   2,502 484 SH   SOLE   484 0 0
ATARA BIOTHERAPEUTICS INC Common Stock 046513107   3,162 964 SH   SOLE   964 0 0
BIOMEA FUSION INC Common Stock 09077A106   2,512 298 SH   SOLE   298 0 0
C4 THERAPEUTICS INC Common Stock 12529R107   2,932 497 SH   SOLE   497 0 0
CODEXIS INC Common Stock 192005106   3,113 668 SH   SOLE   668 0 0
CONCERT PHARMACEUTICALS INC Common Stock 206022105   2,844 487 SH   SOLE   487 0 0
FOGHORN THERAPEUTICS INC Common Stock 344174107   2,712 425 SH   SOLE   425 0 0
GRITSTONE BIO INC Common Stock 39868T105   2,922 847 SH   SOLE   847 0 0
G1 THERAPEUTICS INC Common Stock 3621LQ109   2,791 514 SH   SOLE   514 0 0
CUE HEALTH INC Common Stock 229790100   3,142 1,518 SH   SOLE   1,518 0 0
CENTURY THERAPEUTICS INC Common Stock 15673T100   3,073 599 SH   SOLE   599 0 0
KINNATE BIOPHARMA INC Common Stock 49705R105   2,733 448 SH   SOLE   448 0 0
KARYOPHARM THERAPEUTICS INC Common Stock 48576U106   2,805 825 SH   SOLE   825 0 0
MEIRAGTX HOLDINGS PLC Common Stock G59665102   2,967 455 SH   SOLE   455 0 0
NKARTA INC Common Stock 65487U108   2,971 496 SH   SOLE   496 0 0
OMEGA THERAPEUTICS INC Common Stock 68217N105   2,786 488 SH   SOLE   488 0 0
PHIBRO ANIMAL HEALTH CORP-A Common Stock 71742Q106   2,776 207 SH   SOLE   207 0 0
PEPGEN INC Common Stock 713317105   3,209 240 SH   SOLE   240 0 0
PETIQ INC Common Stock 71639T106   2,711 294 SH   SOLE   294 0 0
PRECIGEN INC Common Stock 74017N105   3,213 2,114 SH   SOLE   2,114 0 0
PAYPAL HOLDINGS INC Common Stock 70450Y103   2,421 34 SH   SOLE   34 0 0
ACUMEN PHARMACEUTICALS INC Common Stock 00509G209   2,246 416 SH   SOLE   416 0 0
ABSCI CORP Common Stock 00091E109   1,972 939 SH   SOLE   939 0 0
ADAPTIMMUNE THERAPEUTICS-ADR ADR 00653A107   2,145 1,469 SH   SOLE   1,469 0 0
AFFIMED NV Common Stock N01045108   1,881 1,517 SH   SOLE   1,517 0 0
COMPASS PATHWAYS PLC ADR 20451W101   1,927 240 SH   SOLE   240 0 0
CENTESSA PHARMACEUTICALS-ADR ADR 152309100   1,652 533 SH   SOLE   533 0 0
EVELO BIOSCIENCES INC Common Stock 299734103   1,792 1,113 SH   SOLE   1,113 0 0
EXSCIENTIA PLC ADR 30223G102   1,956 367 SH   SOLE   367 0 0
GENERATION BIO CO Common Stock 37148K100   2,374 604 SH   SOLE   604 0 0
GOSSAMER BIO INC Common Stock 38341P102   2,083 960 SH   SOLE   960 0 0
GRACELL BIOTECHNOLOGIES-ADR ADR 38406L103   1,559 678 SH   SOLE   678 0 0
GREENLIGHT BIOSCIENCES HOLDI Common Stock 39536G105   1,816 1,539 SH   SOLE   1,539 0 0
GRAPHITE BIO INC Common Stock 38870X104   1,962 591 SH   SOLE   591 0 0
HUMACYTE INC Common Stock 44486Q103   2,209 1,047 SH   SOLE   1,047 0 0
I-MAB-SPONSORED ADR ADR 44975P103   2,312 553 SH   SOLE   553 0 0
INVIVYD INC Common Stock 00534A102   1,661 1,107 SH   SOLE   1,107 0 0
MARINUS PHARMACEUTICALS INC Common Stock 56854Q200   1,930 485 SH   SOLE   485 0 0
NAUTILUS BIOTECHNOLOGY INC Common Stock 63909J108   2,281 1,267 SH   SOLE   1,267 0 0
OCULAR THERAPEUTIX INC Common Stock 67576A100   2,197 782 SH   SOLE   782 0 0
OPTINOSE INC Common Stock 68404V100   2,065 1,116 SH   SOLE   1,116 0 0
PRELUDE THERAPEUTICS INC Common Stock 74065P101   2,235 370 SH   SOLE   370 0 0
QUANTUM-SI INC Common Stock 74765K105   2,229 1,218 SH   SOLE   1,218 0 0
SELECTA BIOSCIENCES INC Common Stock 816212104   1,756 1,554 SH   SOLE   1,554 0 0
ALAUNOS THERAPEUTICS INC Common Stock 98973P101   1,585 2,442 SH   SOLE   2,442 0 0
UROGEN PHARMA LTD Common Stock M96088105   2,076 234 SH   SOLE   234 0 0
XERIS BIOPHARMA HOLDINGS INC Common Stock 98422E103   1,837 1,381 SH   SOLE   1,381 0 0
WALMART INC Common Stock 931142103   711 5 SH   SOLE   5 0 0
EIGER BIOPHARMACEUTICALS INC Common Stock 28249U105   527 447 SH   SOLE   447 0 0
IMMUNEERING CORP - CLASS A Common Stock 45254E107   1,300 268 SH   SOLE   268 0 0
OMEROS CORP Common Stock 682143102   1,440 637 SH   SOLE   637 0 0
INSTIL BIO INC Common Stock 45783C101   830 1,318 SH   SOLE   1,318 0 0
SEA LTD-ADR ADR 81141R100   416 8 SH   SOLE   8 0 0