Structure Therapeutics Inc.

601 Gateway Blvd., Suite 900

South San Francisco, CA 94080

June 3, 2024

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Joshua Gorsky

RE:	Structure Therapeutics Inc.
	Registration Statement on Form S-1
	Filed June 3, 2024
	File No. 333-279915

Acceleration Request

Requested Date: June 5, 2024

Requested Time: 4:00 p.m. Eastern Time

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Structure Therapeutics, Inc. (the “Company”) hereby requests that the Securities and Exchange Commission (the “Commission”) accelerate the effective date of the above-referenced Registration Statement on Form S-1 (the “Registration Statement”) and declare the Registration Statement effective as of 4:00 p.m. Eastern time, on June 5, 2024, or as soon thereafter as possible, or at such other time as the Company or its counsel may request by telephone to the staff of the Commission. The Company hereby authorizes each of Patrick Loofbourrow and Jean Park of Cooley LLP, counsel to the Company, to make such a request on its behalf. This request for acceleration is subject, however, to your receiving a telephone call prior to such time from Cooley LLP confirming this request.

Once the Registration Statement has been declared effective, please orally confirm that event with Patrick Loofbourrow of Cooley LLP at (619) 840-4824, or in his absence, Jean Park of Cooley LLP at (212) 479-6131.

Under separate cover, you will receive today a letter from the managing underwriters of the proposed offering joining in the Company’s request for acceleration of the effectiveness of the Registration Statement.

[Signature Page Follows]

Sincerely,

Structure Therapeutics Inc.

By:	/s/ Raymond Stevens
	Raymond Stevens, Ph.D.
	Chief Executive Officer