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Stock compensation plan (Tables)
 3 Months Ended
Mar. 31, 2024
Share-Based Payment Arrangement [Abstract]  
Share-based Compensation, Activity
Stock option activity under the 2011 Plan, 2018 Plan, Inducement Plan and Assumed Plans for the three months ended March 31, 2024 was as follows:
Number of OptionsWeighted Average Exercise Price
Per Share		Weighted Average Contractual Life (Years)
Outstanding - December 31, 20239,199,744$5.223.84
Exercised(229,417)2.00
Forfeited(94)4.58
Expired(26,556)5.44
Outstanding - March 31, 20248,943,677$5.293.56
Vested and expected to vest at March 31, 20248,943,677$5.293.56
Exercisable - March 31, 20248,796,588$5.303.50
Share-based Payment Arrangement, Expensed and Capitalized, Amount
The following table summarizes the reporting of total stock-based compensation expense resulting from stock options, RSUs and the ESPP (in thousands):
 Three Months Ended March 31,
20242023
Research and development$337 $322 
Selling, general and administrative3,430 2,242 
     Total stock-based compensation expense$3,767 $2,564 
Schedule of Nonvested Restricted Stock Units Activity
A summary of outstanding RSU awards and the activity for the three months ended March 31, 2024 was as follows:
Number of UnitsWeighted Average Grant Date Fair Value
Per Share
Unvested balance - December 31, 202311,579,548$1.83 
Granted9,111,2502.46 
Vested(3,776,815)2.09 
Forfeited (136,118)1.94 
Unvested balance - March 31, 2024
16,777,865$2.11