Warrants Schedule of Stockholders' Equity Note, Warrants or Rights (Details)	Dec. 31, 2021 $ / shares shares
Class of Warrant or Right [Line Items]
Outstanding warrants	4,540,437
Term A Warrants [Member]
Class of Warrant or Right [Line Items]
Outstanding warrants	53,720
Exercise Price Per Warrant | $ / shares	$ 11.169
Term B Warrants [Member]
Class of Warrant or Right [Line Items]
Outstanding warrants	40,292
Exercise Price Per Warrant | $ / shares	$ 11.169
Assumed Strongbridge Private Placement Warrants
Class of Warrant or Right [Line Items]
Outstanding warrants	4,446,425
Exercise Price Per Warrant | $ / shares	$ 3.005
Warrants In Connection With Horizon and Oxford Loan Agreement
Class of Warrant or Right [Line Items]
Outstanding warrants	125,999
Exercise Price Per Warrant | $ / shares	$ 3.130
Warrants In Connection With CRG Loan Agreement
Class of Warrant or Right [Line Items]
Outstanding warrants	309,122
Exercise Price Per Warrant | $ / shares	$ 9.410
Warrants In Connection With CRG Loan Amendment Dated January 2028
Class of Warrant or Right [Line Items]
Outstanding warrants	978,628
Exercise Price Per Warrant | $ / shares	$ 12.760
Warrants In Connection With Avenue Capital Loan Agreement Due May 2025
Class of Warrant or Right [Line Items]
Outstanding warrants	209,633
Exercise Price Per Warrant | $ / shares	$ 2.390
Warrants In Connection With Avenue Capital Loan Agreement Due December 2025
Class of Warrant or Right [Line Items]
Outstanding warrants	209,633
Exercise Price Per Warrant | $ / shares	$ 2.390
Total Warrants Assumed
Class of Warrant or Right [Line Items]
Outstanding warrants	1,833,015