SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 13G

(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT

TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED

PURSUANT TO § 240.13d-2

(Amendment No._)*

Cactus Acquisition Corp. 1 Ltd.

(Name of Issuer)

Class A ordinary shares, par value $0.0001 per share

(Title of Class of Securities)

G1745A108**

(CUSIP Number)

December 31, 2021

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☐ Rule 13d-1(c)

☒ Rule 13d-1(d)

*

The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

**

The CUSIP number for the Issuer’s Class A Ordinary Shares is G1745A108. While the Class A ordinary shares reported in this Schedule 13G consist of Class A ordinary shares issuable upon conversion, on a one-for-one basis, of the Issuer’s Class B ordinary shares, $0.0001 par value per share (“Class B ordinary shares”), the Class B ordinary shares are not registered under the Exchange Act and do not have a CUSIP.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934, as amended (the “Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. G1745A108 13G Page 2 of 8 Pages

1.	Names of Reporting Persons Cactus Healthcare Management LP
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐           (b) ☐
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Delaware

Number of Shares Beneficially Owned by Each Reporting Person with	5.	Sole Voting Power 3,162,500 (1) (2)
	6.	Shared Voting Power 0
	7.	Sole Dispositive Power 3,162,500 (1)
	8.	Shared Dispositive Power 0

9.	Aggregate Amount Beneficially Owned by Each Reporting Person 3,162,500 (1)
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐
11.	Percent of Class Represented by Amount in Row (9) 20% (3)
12.	Type of Reporting Person (See Instructions) PN

(1)	Consists of 3,162,500 Class A ordinary shares issuable upon conversion of an equal number of Class B ordinary shares that are held by the Reporting Person. The foregoing conversion will occur automatically on the first business day following consummation of a business combination by the Issuer. Excludes 4,866,667 Class A ordinary shares underlying warrants held by the Reporting Person, which are not exercisable as of, or within 60 days of, the date of this Schedule 13G.
(2)	The 3,162,500 Class B ordinary shares (which are convertible into 3,162,500 Class A ordinary shares) have the right to vote on the appointment of directors prior to an initial business combination by the Issuer. With respect to any other matter submitted to a vote of the Issuer’s shareholders, including any vote in connection with an initial business combination, the Class A ordinary shares and Class B ordinary shares vote together as a single class, with one vote per share.
(3)	The percentage of Class A ordinary shares is calculated based upon 15,812,500 Class A ordinary shares, consisting of 12,650,000 Class A ordinary shares and an additional 3,162,500 Class A ordinary shares underlying Class B ordinary shares that are issued and outstanding, as reported in the Issuer’s Prospectus filed with the Securities and Exchange Commission (the “SEC”) pursuant to Rule 424(b)(4) on November 1, 2021 and the Issuer’s Current Report on Form 8-K filed with the SEC on November 3, 2021, after giving effect to the completion of the Issuer’s initial public offering, including the full exercise of the underwriters’ over-allotment option for that offering, as described therein.

CUSIP No. G1745A108* 13G Page 3 of 8 Pages

1.	Names of Reporting Persons Cactus Healthcare Management LLC
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐           (b) ☐
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Delaware

Number of Shares Beneficially Owned by Each Reporting Person with	5.	Sole Voting Power 0
	6.	Shared Voting Power 3,162,500 (1) (2)
	7.	Sole Dispositive Power 0
	8.	Shared Dispositive Power 3,162,500 (1)

9.	Aggregate Amount Beneficially Owned by Each Reporting Person 3,162,500 (1)
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐
11.	Percent of Class Represented by Amount in Row (9) 20% (3)
12.	Type of Reporting Person (See Instructions) PN

(1)	Consists of 3,162,500 Class A ordinary shares issuable upon conversion of an equal number of Class B ordinary shares that are held by Cactus Healthcare Management LP (for which the Reporting Person serves as sole general partner). The foregoing conversion will occur automatically on the first business day following consummation of a business combination by the Issuer. Excludes 4,866,667 Class A ordinary shares underlying warrants held by Cactus Healthcare Management LP, which are not exercisable as of, or within 60 days of, the date of this Schedule 13G.
(2)	The 3,162,500 Class B ordinary shares (which are convertible into 3,162,500 Class A ordinary shares) have the right to vote on the appointment of directors prior to an initial business combination by the Issuer. With respect to any other matter submitted to a vote of the Issuer’s shareholders, including any vote in connection with an initial business combination, the Class A ordinary shares and Class B ordinary shares vote together as a single class, with one vote per share.
(3)	The percentage of Class A ordinary shares is calculated based upon 15,812,500 Class A ordinary shares, consisting of 12,650,000 Class A ordinary shares and an additional 3,162,500 Class A ordinary shares underlying Class B ordinary shares that are issued and outstanding, as reported in the Issuer’s Prospectus filed with the SEC pursuant to Rule 424(b)(4) on November 1, 2021 and the Issuer’s Current Report on Form 8-K filed with the SEC on November 3, 2021, after giving effect to the completion of the Issuer’s initial public offering, including the full exercise of the underwriters’ over-allotment option for that offering, as described therein.

CUSIP No. G1745A108* 13G Page 4 of 8 Pages

Item 1(a). Name of Issuer:

The name of the issuer is Cactus Acquisition Corp. 1 Limited (the “Issuer”).

Item 1(b). Address of Issuer’s Principal Executive Offices:

The Issuer’s principal executive offices are located at 4B Cedar Brook Drive, Cranbury, NJ 08512.

Item 2(a). Name of Person Filing:

The following entities, listed in (i) and (ii) below, who are filing this Statement of Beneficial Ownership on Schedule 13G (this “Statement”), are referred to herein collectively as the “Reporting Persons”:

(i)	Cactus Healthcare Management LP (the “Sponsor”)
(ii)	Cactus Healthcare Management LLC (the “GP”)

The Sponsor directly holds the securities of the Issuer that are reported in this Statement. The GP serves as the sole general partner of the Sponsor and may therefore be deemed to share voting and investment authority with respect to the securities of the Issuer held thereby. Each of Hibotan LLC (an affiliate of Israel Biotech Fund), Kalistcare Limited (an affiliate of Consensus Business Group), and Clal Biotechnology Industries Cactus Ltd. (an affiliate of Clal Biotechnology Industries Ltd.) holds an equal 33.33% equity interest in the GP. No single entity or individual possesses the ability to control the voting or investment decisions made by the GP.

Item 2(b). Address of Principal Business Office or, if None, Residence:

The principal business office of each Reporting Person is c/o Cactus Acquisition Corp. 1 Limited, 4B Cedar Brook Drive, Cranbury, NJ 08512.

Item 2(c). Citizenship:

The citizenship or state of organization, as applicable, of each Reporting Person is as follows:

(i) Sponsor— Delaware

(ii) GP— Delaware

Item 2(d). Title of Class of Securities:

This Statement relates to the Class A ordinary shares, par value $0.0001 per share, of the Issuer (“Class A ordinary shares”), which are registered under Section 12(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), including Class A ordinary shares issuable upon conversion of an equivalent number of Class B ordinary shares, par value $0.0001 per share (“Class B ordinary shares”). While the Class B ordinary shares are not registered under the Exchange Act, this Statement treats the Class B ordinary shares as part of one class together with the Class A ordinary shares, because Class B ordinary shares (i) generally possess the same rights as the Class A ordinary shares (except that Class B ordinary shares are entitled to vote for directors, whereas Class A ordinary shares are not) and (ii) generally automatically convert into Class A ordinary shares on a one-for-one basis upon a business combination of the Issuer.

CUSIP No. G1745A108* 13G Page 5 of 8 Pages

Item 2(e). CUSIP Number:

The CUSIP number of the Class A ordinary shares is G1745A108.

Item 3. If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b), or (c), check whether the person filing is a:

(a)	☐	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
(b)	☐	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
(c)	☐	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
(d)	☐	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
(e)	☐	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	☐	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	☐	A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);
(h)	☐	A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C.1813);
(i)	☐	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	☐	A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);
(k)	☐	Group, in accordance with §240.13d-1(b)(1)(ii)(K).

If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution: _________________

Not applicable.

Item 4. Ownership.

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

I. Cactus Healthcare Management LP

(a) Amount beneficially owned: 3,162,500 (1) (2)

(b) Percent of class*: 20%

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 3,162,500 (1) (2)

(ii) Shared power to vote or to direct the vote: 0

(iii) Sole power to dispose of or to direct the disposition of: 3,162,500 (1) (2)

(iv) Shared power to dispose of or to direct the disposition of: 0

CUSIP No. G1745A108* 13G Page 6 of 8 Pages

II. Cactus Healthcare Management LLC

(a) Amount beneficially owned: 3,162,500 (1) (2)

(b) Percent of class*: 20%

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 3,162,500 (1) (2)

(iii) Sole power to dispose of or to direct the disposition of: 0

(iv) Shared power to dispose of or to direct the disposition of: 3,162,500 (1) (2)

* All percentage ownership information reflected in this Statement is based on 15,812,500 Class A ordinary shares, consisting of 12,650,000 issued and outstanding Class A ordinary shares and an additional 3,162,500 Class A ordinary shares that are issuable upon conversion on a one-for-one basis of an equivalent number of Class B ordinary shares, that are issued and outstanding. Those numbers were reported in the Issuer’s Prospectus filed with the Securities and Exchange Commission (the “SEC”) pursuant to Rule 424(b)(4) on November 1, 2021 and the Issuer’s Current Report on Form 8-K filed with the SEC on November 3, 2021, after giving effect to the completion of the Issuer’s initial public offering and full exercise of the underwriters’ over-allotment option in that offering, as described therein.

(1) See the cover page for the applicable Reporting Person, which is incorporated by reference herein, for the explanation as to the basis for the beneficial ownership of these ordinary shares by the Reporting Person.

(2) As further described in Item 2(d) above, this Statement treats the Class B ordinary shares as part of one class together with the Class A ordinary shares, so the amount of Class A ordinary shares beneficially owned consists of Class A ordinary shares underlying an equal number of Class B ordinary shares (3,162,500).

Each of the foregoing Reporting Persons disclaims beneficial ownership of the Class A ordinary shares reported herein except to the extent of its pecuniary interest (if any) therein.

Item 5. Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: ☐

Item 6. Ownership of More Than Five Percent on Behalf of Another Person.

Not applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

Not applicable.

Item 8. Identification and Classification of Members of the Group.  

Not applicable.

Item 9. Notice of Dissolution of Group.  

Not applicable.

Item 10. Certifications.  

Not applicable.

CUSIP No. G1745A116* 13G Page 7 of 8 Pages

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Cactus Healthcare Management LP
By:	Cactus Healthcare Management LLC, its sole General Partner
	By:	/s/ Stephen T. Wills
	Name:	Stephen T. Wills
	Title:	Secretary
Cactus Healthcare Management LLC
	By:	/s/ Stephen T. Wills
	Name:	Stephen T. Wills
	Title:	Secretary

Dated: March 21, 2022

 

CUSIP No. G1745A116* 13G Page 8 of 8 Pages

EXHIBITS

Exhibit 1 – Joint Filing Agreement pursuant to Rule 13d-1(k)(1)