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Property, plant and equipment, net
 12 Months Ended
Dec. 31, 2023
Property, Plant and Equipment [Abstract]  
Property, plant and equipment, net Property, plant and equipment, net
Property, plant and equipment, net, consists of the following (in thousands):
As of December 31,
20232022
Computer equipment and software6,156 5,670 
Office equipment6,726 6,159 
Laboratory equipment43,209 36,216 
Leasehold improvements58,832 27,416 
Construction-in-progress138 28,112 
Total property, plant and equipment115,061 103,573 
Less accumulated depreciation and amortization(56,911)(47,838)
Property, plant and equipment, net$58,150 $55,735 
Depreciation and amortization expense related to property, plant and equipment was $9.6 million, $8.9 million, and $12.1 million for the years ended December 31, 2023, 2022, and 2021, respectively.
Cambridge, Massachusetts drug product manufacturing facility
In February 2022, the Company began construction of a drug product manufacturing facility within its Cambridge, Massachusetts headquarters. The facility enables rapid translational research in clinical trials and the manufacture of drug product for use in Phase 1 clinical development activities. The facility became fully operational as of August 2023 and related construction-in-progress totaling $36.6 million related to the build-out of the facility was placed into service. As of December 31, 2022, construction-in-progress included $27.0 million related to the build-out of the facility.