Property, plant and equipment, net - Narrative (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Sep. 30, 2022
Property, Plant and Equipment [Line Items]
Depreciation	$ 8,900	$ 12,100	$ 9,400
Construction in progress	103,573	74,991
Lentiviral Vector Manufacturing Facility
Property, Plant and Equipment [Line Items]
Net assets disposed of				$ 111,200
Construction-in-progress
Property, Plant and Equipment [Line Items]
Construction in progress	28,112	$ 3,462
Construction-in-progress | Cambridge, Massachusetts
Property, Plant and Equipment [Line Items]
Construction in progress	$ 27,000