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Condensed Consolidated and Combined Statements of Cash Flows - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flows from operating activities:    
Net loss $ (85,711) $ (87,196)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:    
Change in fair value of contingent consideration 48 369
Depreciation and amortization 3,530 3,676
Stock-based compensation expense 9,739 17,109
Other non-cash items 1,227 69
Changes in operating assets and liabilities:    
Prepaid expenses and other assets (7,768) 2,262
Operating lease right-of-use assets 4,710 3,652
Accounts payable 6,228 4,535
Accrued expenses and other liabilities 280 (1,248)
Operating lease liabilities (2,860) (5,639)
Deferred revenue 0 (820)
Collaboration research advancement (3,487) (1,519)
Net cash used in operating activities (74,064) (64,750)
Cash flows from investing activities:    
Purchases of property, plant and equipment (3,585) (6,351)
Purchases of marketable securities (22,450) 0
Proceeds from maturities of marketable securities 70,784 0
Net cash provided by (used in) investing activities 44,749 (6,351)
Cash flows from financing activities:    
Transfers from bluebird bio 0 71,101
Proceeds from issuance of common stock in private placement 170,000 0
Proceeds from exercise of stock options and ESPP contributions 99 0
Net cash provided by financing activities 170,099 71,101
Increase (decrease) in cash, cash equivalents and restricted cash 140,784 0
Cash, cash equivalents and restricted cash at beginning of period 163,266 0
Cash, cash equivalents and restricted cash at end of period 304,050 0
Reconciliation of cash, cash equivalents, and restricted cash    
Cash and cash equivalents 270,893 0
Restricted cash included in restricted cash and other non-current assets 33,157 0
Total cash, cash equivalents, and restricted cash 304,050 0
Supplemental cash flow disclosures:    
Purchases of property, plant and equipment included in accounts payable and accrued expenses 2,925 1,954
Private placement issuance costs included in accounts payable and accrued expenses $ 4,343 $ 0