Stockholders' equity - Common Stock Reserved for Future Issuance (Details) - shares shares in Thousands	Dec. 31, 2021	Dec. 31, 2020
Subsidiary, Sale of Stock [Line Items]
Common stock reserved for future issuance (in shares)	5,686	0
Pre-funded Warrants
Subsidiary, Sale of Stock [Line Items]
Common stock reserved for future issuance (in shares)	758
2021 Stock Option and Incentive Plan
Subsidiary, Sale of Stock [Line Items]
Common stock reserved for future issuance (in shares)	2,125	0
2021 Employee Stock Purchase Plan
Subsidiary, Sale of Stock [Line Items]
Common stock reserved for future issuance (in shares)	233	0
Options to purchase common stock
Subsidiary, Sale of Stock [Line Items]
Common stock reserved for future issuance (in shares)	1,490	0
Restricted stock units
Subsidiary, Sale of Stock [Line Items]
Common stock reserved for future issuance (in shares)	1,080	0