Accrued expenses and other current liabilities - Summary of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Payables and Accruals [Abstract]
Employee compensation	$ 24,655	$ 9,451
Royalties	6,768	1,493
Manufacturing costs	5,459	6,808
Clinical and contract research organization costs	3,229	2,854
Collaboration research costs	2,576	19,605
Property, plant, and equipment	2,241	440
Professional fees	1,688	0
Separation related costs	762	0
License and milestone fees	123	278
Other	7,909	2,418
Total accrued expenses and other current liabilities	$ 55,410	$ 43,347