Summary of significant accounting policies and basis of presentation - Estimated Useful Lives of Assets (Detail)	12 Months Ended
	Dec. 31, 2021
Building
Property, Plant and Equipment [Line Items]
Estimated useful life	40 years
Computer equipment and software
Property, Plant and Equipment [Line Items]
Estimated useful life	3 years
Furniture and fixtures | Minimum
Property, Plant and Equipment [Line Items]
Estimated useful life	2 years
Furniture and fixtures | Maximum
Property, Plant and Equipment [Line Items]
Estimated useful life	5 years
Laboratory equipment | Minimum
Property, Plant and Equipment [Line Items]
Estimated useful life	2 years
Laboratory equipment | Maximum
Property, Plant and Equipment [Line Items]
Estimated useful life	5 years