Stock-based compensation (Tables)

12 Months Ended

Dec. 31, 2021

Share-based Payment Arrangement [Abstract]

Stock-based Compensation Expense Recognized by Award Type

Stock-based compensation expense recognized by award type is as follows (in thousands):

	Year Ended December 31,
	2021		2020		2019
Stock options	$	26,185	$	36,685	$	36,792
Restricted stock units	21,414		19,185		24,744
Employee stock purchase plan and other	7,030		5,127		512
	$	54,629	$	60,997	$	62,049

Schedule of Stock-Based Compensation Expense by Classification

Stock-based compensation expense by classification included within the consolidated statements of operations and comprehensive loss was as follows (in thousands):

	Year Ended December 31,
	2021		2020		2019
Research and development	$	29,746	$	30,935	$	33,853
Selling, general and administrative	24,883		30,062		28,196
	$	54,629	$	60,997	$	62,049

Summary of Stock Option Activity

The following table summarizes the stock option activity under the Company’s equity awards plans for 2seventy employees:

	Shares (in thousands)	Weighted-average exercise price per share		Weighted-average contractual life (in years)	Aggregate intrinsic value (a) (in thousands)
Outstanding at December 31, 2020	—	$	—
Granted	—	$	—
Converted in distribution	875	$	129.67
Exercised	—	$	—
Canceled or forfeited	(2)	$	157.43
Outstanding at December 31, 2021	873	$	129.60	6.6	$	131
Exercisable at December 31, 2021	518	$	161.76	5.2	$	131
Vested and expected to vest at December 31, 2021	873	$	129.60	6.6	$	131

(a) The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying options and the fair value of the common stock for the options that were in the money at December 31, 2021.

Summary of Restricted Stock Unit Activity

The following table summarizes the restricted stock unit activity under the Company’s equity award plans for 2seventy employees:

	Shares (in thousands)	Weighted-average exercise price per share
Unvested balance at December 31, 2020	—	$	—
Granted	9	36.14
Converted in distribution	969	50.93
Vested	(3)	137.65
Forfeited	(4)	86.12
Unvested balance at December 31, 2021	971	$	50.56