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Fair value measurements
12 Months Ended
Dec. 31, 2021
Fair Value Disclosures [Abstract]  
Fair value measurements Fair value measurements
The following table sets forth the Company’s assets and liabilities that are measured at fair value on a recurring basis as of December 31, 2021 and 2020 (in thousands):
Total
Quoted prices in active markets
 (Level 1)
Significant other observable inputs
(Level 2)
Significant unobservable inputs
(Level 3)
December 31, 2021
Assets:
Cash and cash equivalents$130,414 $130,414 $— $— 
Marketable securities:
U.S. government agency securities and treasuries128,392 — 128,392 — 
Corporate bonds49,310 — 49,310 — 
Commercial paper54,065 — 54,065 — 
Total assets$362,181 $130,414 $231,767 $— 
Liabilities:
Contingent consideration$1,948 $— $— $1,948 
Total liabilities$1,948 $— $— $1,948 
December 31, 2020
Liabilities:
Contingent consideration$1,509 $— $— $1,509 
Total liabilities$1,509 $— $— $1,509 
As of December 31, 2020, the Company did not hold any assets that were measured at fair value on a recurring basis.
Marketable securities
Marketable securities classified as Level 2 within the valuation hierarchy generally consist of U.S. government agency securities and treasuries, corporate bonds, and commercial paper. The Company estimates the fair values of these marketable securities by taking into consideration valuations obtained from third-party pricing sources. These pricing sources utilize industry standard valuation models, including both income and market-based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include market pricing based on real-time trade data for the same or similar securities, issuer credit spreads, benchmark yields, and other observable inputs. The Company validates the prices provided by its third-party pricing sources by understanding the models used, obtaining market values from other pricing sources and analyzing pricing data in certain instances.
The amortized cost of available-for-sale debt securities is adjusted for amortization of premiums and accretion of discounts to the earliest call date for premiums or to maturity for discounts. At December 31, 2021, the balance in the Company’s accumulated other comprehensive loss was composed primarily of activity related to the Company’s available-for-sale debt securities. There were no material realized gains or losses recognized on the sale or maturity of available-for-sale securities during the year ended December 31, 2021.
Accrued interest receivable on the Company's available-for-sale debt securities totaled $0.4 million as of December 31, 2021. No accrued interest receivable was written off during the twelve months ended December 31, 2021.
The following table summarizes available-for-sale debt securities in a continuous unrealized loss position for less than and greater than twelve months, and for which an allowance for credit losses has not been recorded at December 31, 2021 (in thousands):
Less than 12 months12 months or greaterTotal
DescriptionFair valueUnrealized lossesFair valueUnrealized lossesFair valueUnrealized losses
December 31, 2021
U.S. government agency securities and
    treasuries
$111,190 $(507)$— $— $111,190 $(507)
Corporate bonds48,940 (58)— — 48,940 (58)
Total$160,130 $(565)$— $— $160,130 $(565)

The Company determined that there was no material change in the credit risk of the above investments during the twelve months ended December 31, 2021. As such, an allowance for credit losses was not recognized. As of December 31, 2021, the Company does not intend to sell such securities and it is not more likely than not that the Company will be required to sell the securities before recovery of their amortized cost bases.
Contingent consideration
In connection with bluebird bio's prior acquisition of Precision Genome Engineering, Inc. (“Pregenen”), the Company may be required to pay future consideration that is contingent upon the achievement of specified development, regulatory approvals or sales-based milestone events. Contingent consideration is measured at fair value and is based on significant unobservable inputs, which represents a Level 3 measurement within the fair value hierarchy. The valuation of contingent consideration uses assumptions the Company believes would be made by a market participant. The Company assesses these estimates on an on-going basis as additional data impacting the assumptions is obtained. Future changes in the fair value of contingent consideration related to updated assumptions and estimates are recognized within the consolidated and combined statements of operations and comprehensive loss. In the absence of new information related to the probability of milestone achievement, changes in fair value will reflect changing discount rates and the passage of time. Contingent consideration is included in other non-current liabilities on the consolidated and combined balance sheets.
The table below provides a roll-forward of fair value of the Company’s contingent consideration obligations that include Level 3 inputs (in thousands):
Year ended December 31,
20212020
Beginning balance$1,509 $7,977 
Additions— — 
Changes in fair value439 (6,468)
Payments— — 
Ending balance$1,948 $1,509 
Please refer to Note 8, Commitments and contingencies, for further information.