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Note 10 - License and Development Agreements (Details Textual) - USD ($)
6 Months Ended
Jun. 30, 2024
Sep. 30, 2024
Sep. 01, 2024
May 01, 2024
Mar. 01, 2024
Jan. 26, 2024
Dec. 31, 2023
May 26, 2023
Accounts Payable, Current   $ 4,693,000         $ 8,416,000  
Convertible Notes Payable, Current   1,337,000         1,300,000  
Accrued Liabilities, Current   1,322,000         $ 1,309,000  
Milestone Payment, Sales $ 50,000,000              
Licensed Product Sales 1,000,000,000              
Maximum [Member]                
Milestone Payment $ 94,000,000              
Already Paid [Member]                
License Agreement, Periodic Payment               $ 100,000
Paid Within 10 Days of Fourth Amendment Execution [Member]                
License Agreement, Periodic Payment               50,000
Completion of Capital Raise [Member]                
License Agreement, Periodic Payment               $ 100,000
Payment on or Before March 1, 2024 [Member]                
License Agreement, Periodic Payment         $ 850,000      
Fifth Amendment Agreement [Member]                
License Agreement, Periodic Payment       $ 200,000        
Payment Due by September 1, 2024 [Member]                
License Agreement, Periodic Payment     $ 850,000          
Convertible Promissory Note Due to Novartis [Member]                
Debt Instrument, Interest Rate, Stated Percentage           5.00%    
Accounts Payable, Current   3,600,000            
Convertible Notes Payable, Current   1,300,000            
Accrued Liabilities, Current   $ 200,000            
Eisai Royalties One [Member] | Maximum [Member]                
Royalty Annul Percentage 10.00%              
Payments for Royalties $ 100,000,000              
Eisai Royalties One [Member] | Minimum [Member]                
Royalty Annul Percentage 5.00%              
Payments for Royalties $ 0              
Eisai Royalty Two [Member] | Maximum [Member]                
Royalty Annul Percentage 10.00%              
Payments for Royalties $ 250,000,000              
Eisai Royalty Two [Member] | Minimum [Member]                
Royalty Annul Percentage 6.00%              
Payments for Royalties $ 100,000,000              
Eisai Royalties Three [Member] | Maximum [Member]                
Royalty Annul Percentage 11.00%              
Payments for Royalties $ 500,000,000              
Eisai Royalties Three [Member] | Minimum [Member]                
Royalty Annul Percentage 7.00%              
Payments for Royalties $ 250,000,000              
Eisai Royalties Four [Member]                
Payments for Royalties $ 500,000,000              
Eisai Royalties Four [Member] | Maximum [Member]                
Royalty Annul Percentage 15.00%              
Eisai Royalties Four [Member] | Minimum [Member]                
Royalty Annul Percentage 11.00%