Exhibit 99.1

Information on the total number of voting rights and shares

December 29, 2022

REGULATED INFORMATION

Information on the total number of voting rights and shares

Mont-Saint-Guibert (Belgium), December 29, 2022, 10:30 pm CET / 4:30 pm ET – In accordance with article 15 of the Law of 2 May 2007 on the disclosure of large shareholdings, Nyxoah SA (Euronext Brussels and Nasdaq: NYXH) publishes the belowinformation following the issue of new warrants.

● Share capital: EUR 4,440,069.16

● Total number of securities carrying voting rights: 25,846,279 (all ordinary shares)

● Total number of voting rights (= denominator): 25,846,279 (all relating to ordinary shares)

● Number of rights to subscribe to securities carrying voting rights not yet issued:

55 “2016 ESOP Warrants” issued on November 3, 2016, entitling their holders to subscribe to a total number of 27,500 securities carrying voting rights (all ordinary shares);

100 “2018 ESOP Warrants” issued on December 12, 2018, entitling their holders to subscribe to a total number of 50,000 securities carrying voting rights (all ordinary shares);

450,500 “2020 ESOP Warrants” issued on February 21, 2020, entitling their holders to subscribe to a total number of 460,500 securities carrying voting rights (all ordinary shares); and

1,350,750 “2021 ESOP Warrants” issued on September 8, 2021, entitling their holders to subscribe to a total number of 1,350,750 securities carrying voting rights (all ordinary shares); and

700,000 “2022 ESOP Warrants” issued on December 28, 2022, entitling their holders to subscribe to a total number of 700,000 securities carrying voting rights (all ordinary shares).

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For further information, please contact:

Nyxoah

Jeremy Feffer, VP IR and Corporate Communications jeremy.feffer@nyxoah.com

+1 917 749 1494

Attachment

● 2022 12 29 - Press release - Number of shares (ENG)