Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the registration statements (Nos. 333- 267390, 333-265873) on Form S-1, (No. 333-262707) on Form S-4, and (Nos. 333-269816, 333-266958) on Form S-8 of our report dated March 22, 2023, with respect to the consolidated financial statements of Senti Biosciences, Inc.

/s/ KPMG LLP

San Francisco, California

March 22, 2023