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Summary of significant accounting policies and basis of presentation - Early exercised options (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2022
Dec. 31, 2021
Summary of significant accounting policies and basis of presentation    
Amount of deposit liability related to shares held by employees and nonemployees that were subject to repurchase $ 2,327 $ 3,000
Total shares legally outstanding 58,880,054 56,633,898
Exercised - unvested (773,394) (946,586)
Less: unvested restricted stock (520,630) (681,789)
Total shares issued and outstanding 57,586,030 55,005,523