Consolidated Statements of Shareholders' Equity - USD ($) $ in Thousands	Total	Ordinary Shares	Additional paid-in capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Ordinary shares, beginning balance (in shares) at Dec. 31, 2022		94,843,391
Beginning balance at Dec. 31, 2022	$ 336,169	$ 265	$ 939,261	$ (1,497)	$ (601,860)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Share-based compensation expense	7,190		7,190
Vesting of ordinary shares (in shares)		332,292
Vesting of ordinary shares	0	$ 1	(1)
Shares withheld to pay employee withholding tax on share-based compensation (in shares)		(72,436)
Shares withheld to pay employee withholding tax on share-based compensation	(282)		(282)
Foreign currency translation adjustments	898			898
Unrealized gain on available for sale securities, net of tax	0
Net loss	(50,714)				(50,714)
Ordinary shares, ending balance (in shares) at Mar. 31, 2023		95,103,247
Ending balance at Mar. 31, 2023	$ 293,261	$ 266	946,168	(599)	(652,574)
Ordinary shares, beginning balance (in shares) at Dec. 31, 2023	98,774,827	98,774,827
Beginning balance at Dec. 31, 2023	$ 236,244	$ 273	987,423	1,493	(752,945)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares under ATM program, net of issuance costs (in shares)		1,250,000
Issuance of ordinary shares under ATM program, net of issuance costs	$ 9,655	$ 3	9,652
Stock option exercises (in shares)	176,460	176,460
Stock option exercises	$ 955		955
Share-based compensation expense	8,154		8,154
Vesting of ordinary shares (in shares)		480,926
Vesting of ordinary shares	0	$ 1	(1)
Shares withheld to pay employee withholding tax on share-based compensation (in shares)		(200,220)
Shares withheld to pay employee withholding tax on share-based compensation	(1,929)		(1,929)
Foreign currency translation adjustments	(25)			(25)
Unrealized gain on available for sale securities, net of tax	155			155
Net loss	$ (38,046)				(38,046)
Ordinary shares, ending balance (in shares) at Mar. 31, 2024	100,481,993	100,481,993
Ending balance at Mar. 31, 2024	$ 215,163	$ 277	$ 1,004,254	$ 1,623	$ (790,991)