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Share-based Compensation (Tables)
 12 Months Ended
Dec. 31, 2023
Share-Based Payment Arrangement [Abstract]  
Summary of Share-based Compensation Expense
The Company recorded share-based compensation expense in the following expense categories in the consolidated statements of operations and comprehensive loss (amounts in thousands):
Year Ended
December 31, 2023		Year Ended
December 31, 2022
Research and development$13,221 $11,954 
General and administrative16,171 13,011 
$29,392 $24,965 
Summary of Stock Option Activity
The following table summarizes stock option activity for the year ended December 31, 2023:
Number of SharesWeighted-Average Exercise Price Per Share
Weighted-Average Remaining Contractual Term
Aggregate
Intrinsic Value
(in millions)
Balance at January 1, 2023
14,688,996 $7.88 8.5 years
Granted3,542,700 4.48 
Exercised(70,197)4.41 
Forfeited(2,092,484)8.37 
Balance at December 31, 2023
16,069,015 $7.09 7.9 years$29.0 
Exercisable at December 31, 2023
8,417,959 $7.41 7.5 years$13.4 
Vested and expected to vest at December 31, 2023
16,069,015 $7.09 7.9 years$29.0 
Schedule of Assumptions Used to Estimate Fair Value of Stock Option Awards
The fair value of each option was estimated on the date of grant using the weighted average assumptions in the table below:
Year Ended
December 31, 2023		Year Ended
December 31, 2022
Weighted-average grant date fair value of options
$3.22$5.38
Expected term (in years)6.026.01
Expected stock price volatility78.3%76.4%
Risk-free interest rate3.8%2.2%
Expected dividend yield0%0%
Summary of Replacement Equity Award Activity
The following table summarizes ordinary share activity related to the restricted stock programs for the year ended December 31, 2023:
Restricted Stock AwardsRestricted Stock Units
Number of SharesWeighted-Average Grant Date Fair Value Per ShareNumber of SharesWeighted-Average Grant Date Fair Value Per Share
Unvested at January 1, 2023
599,421 1,804,760 
Granted— n/a1,443,381 $3.87 
Vested(289,369)(905,297)
Forfeited— (393,381)
Unvested at December 31, 2023
310,052 1,949,463 
Unrecognized compensation expense at December 31, 2023 ($ in thousands)
$5,708 $7,765 
Expected weighted average recognition period
1.3 years1.9 years