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Share-based Compensation (Tables)
 9 Months Ended
Sep. 30, 2023
Share-Based Payment Arrangement [Abstract]  
Summary of Share-based Compensation Expense
The Company recorded share-based compensation expense in the following expense categories in the unaudited interim consolidated statements of operations and comprehensive loss (amounts in thousands):
Three Months Ended
September 30, 2023		Three Months Ended
September 30, 2022		Nine Months Ended
September 30, 2023		Nine Months Ended
September 30, 2022
Research and development$3,326 $3,213 $9,865 $8,700 
General and administrative4,233 3,814 12,097 9,648 
$7,559 $7,027 $21,962 $18,348 
Summary of Stock Option Activity
The following table summarizes stock option activity for the nine months ended September 30, 2023:
Number of SharesWeighted-Average Exercise Price Per ShareWeighted-Average Remaining Contractual Term
Balance at January 1, 202314,688,996 $7.88 8.5 years
Granted2,973,300 $4.18 
Exercised(44,770)$4.28 
Forfeited(1,578,307)$8.33 
Balance at September 30, 2023
16,039,219 $7.16 7.9 years
Exercisable at September 30, 2023
7,764,651 $7.57 7.3 years
Vested and expected to vest at September 30, 2023
16,039,219 $7.16 7.9 years
Schedule of Assumptions Used to Estimate Fair Value of Stock Option Awards
During the nine months ended September 30, 2023, the fair value of each option was estimated on the date of grant using the weighted average assumptions in the table below:
Expected term6.0 years
Expected stock price volatility78.0 %
Risk-free interest rate3.6 %
Expected dividend yield0 %
Summary of Replacement Equity Award Activity
The following table summarizes ordinary share activity related to the restricted stock programs for the nine months ended September 30, 2023:
Restricted Stock AwardsRestricted Stock Units
Number of SharesWeighted-Average Grant Date Fair Value Per ShareNumber of SharesWeighted-Average Grant Date Fair Value Per Share
Unvested at January 1, 2023599,421 1,804,760 
Granted— n/a1,443,381 $3.87 
Vested(232,833)(675,631)
Forfeited— (382,656)
Unvested at September 30, 2023
366,588 2,189,854 
Unrecognized compensation expense
 at September 30, 2023 (in thousands)
$6,823 $9,156 
Expected weighted average recognition period1.6 years2.2 years