Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities:
Net loss	$ (50,714)	$ (54,498)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	7,190	5,718
Depreciation and amortization	89	28
Change in fair value of financial instruments	1,800	1,080
Changes in operating assets and liabilities:
Tax incentive receivable	4,306	(5,728)
Prepaid expenses and other assets	1,899	2,014
Accounts payable	(1,815)	(1,220)
Accrued expenses and other liabilities	(9,768)	2,589
Other, net	(825)	0
Net cash used in operating activities	(47,838)	(50,017)
Cash flows from investing activities:
Purchases of investments in marketable securities	(86,248)	0
Purchases of property and equipment	(88)	(240)
Net cash used in investing activities	(86,336)	(240)
Cash flows from financing activities:
Proceeds from option exercises	0	335
Other, net	0	(261)
Net cash provided by financing activities	0	74
Effect of exchange rate on cash and cash equivalents	518	(434)
Net decrease in cash and cash equivalents	(133,656)	(50,617)
Cash and cash equivalents at beginning of period	393,644	595,082
Cash and cash equivalents at end of period	259,988	544,465
Supplemental disclosure:
Interest paid	2,344	1,500
Income taxes paid	135	0
Non-cash investing and financing activities:
Issuance of ordinary shares to settle outstanding contingent value rights	$ 0	$ 39,680