Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 259,988	$ 393,644
Short-term investments	86,241	0
Tax incentive receivable	20,328	24,166
Prepaid expenses and other current assets	17,773	19,937
Total current assets	384,330	437,747
Property and equipment, net	1,219	1,168
Operating lease right-of-use assets	12,271	0
Other, net	6,040	5,392
Total assets	403,860	444,307
Current liabilities:
Accounts payable	14,368	13,836
Accrued expenses and other current liabilities	15,318	24,502
Total current liabilities	29,686	38,338
Long term debt	71,600	69,800
Operating lease liabilities	9,313	0
Total liabilities	110,599	108,138
Commitments and contingencies (Note 6)
Shareholders’ equity:
Ordinary shares: £0.002 nominal value: 152,500,000 shares authorized, 95,103,247 issued and outstanding at March 31, 2023: 152,500,000 shares authorized, 94,843,391 issued and outstanding at December 31, 2022	266	265
Additional paid-in capital	946,168	939,261
Accumulated other comprehensive loss	(599)	(1,497)
Accumulated deficit	(652,574)	(601,860)
Total shareholders' equity	293,261	336,169
Total liabilities and shareholders' equity	$ 403,860	$ 444,307