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Acquisitions and Dispositions - Additional Information (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 11 Months Ended 12 Months Ended
Jan. 29, 2021
Jan. 29, 2021
Mar. 31, 2022
Dec. 31, 2021
Dec. 31, 2022
Asset Acquisition [Line Items]          
Contingent value rights       $ 37,700 $ 0
Change in fair value of contingent value rights   $ 0   15,082 1,980
Centessa Subsidiaries          
Asset Acquisition [Line Items]          
Percentage of outstanding shares acquired 100.00% 100.00%      
Acquisition of Centessa Subsidiaries (in shares) 44,758,079        
In-process research and development assets $ 223,593        
Transaction costs 4,597 $ 3,100      
Unrecognized compensation expense 4,100 4,100      
Contingent consideration arrangements, range of outcomes, high         39,700
Contingent value rights $ 22,600 $ 22,600      
Change in fair value of contingent value rights     $ 2,000 $ 15,100  
Pega-One | Disposal Group, Held-for-sale or Disposed of by Sale, Not Discontinued Operations          
Asset Acquisition [Line Items]          
Loss on disposition of business         $ 200