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Licensing Arrangements (Details)
£ in Millions
1 Months Ended 3 Months Ended 8 Months Ended 9 Months Ended
Jan. 29, 2021
USD ($)
Sep. 30, 2021
USD ($)
$ / £
Sep. 30, 2020
USD ($)
Sep. 30, 2021
USD ($)
$ / £
Sep. 30, 2021
USD ($)
$ / £
Sep. 30, 2021
GBP (£)
$ / £
Mar. 31, 2019
USD ($)
$ / £
Mar. 31, 2019
GBP (£)
$ / £
Jan. 31, 2019
USD ($)
$ / £
Jan. 31, 2019
GBP (£)
$ / £
Dec. 31, 2015
USD ($)
$ / £
Dec. 31, 2015
GBP (£)
$ / £
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Foreign currency exchange rate, translation | $ / £   0.74   0.74 0.74 0.74 0.86 0.86 0.74 0.74 0.74 0.74
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Research and development expense   $ 0 $ 0 $ 0                
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Z Factor                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments                     $ 500,000 £ 0.4
Research and development expense $ 0 0 $ 0 0 $ 0              
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Morphogen-LX                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments                     $ 1,100,000 £ 0.8
Research and development expense $ 0                      
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Palladio                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Research and development expense       0                
Maximum contingent consideration payment   32,500,000   32,500,000 32,500,000              
Maximum aggregate commercial milestone payments   16,300,000   16,300,000 16,300,000              
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Palladio | Pfizer                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Royalty payments   19,000,000   19,000,000 19,000,000              
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | ApcinteX                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Research and development expense       0                
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | ApcinteX | CE                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments   900,000   900,000 900,000 £ 0.7            
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Pega-One | Roche                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments   16,000,000   16,000,000 16,000,000              
Maximum aggregate commercial milestone payments   125,000,000   125,000,000 125,000,000              
Upfront payment   2,000,000   2,000,000 $ 2,000,000              
Minimum percent of consideration due to counterparty         10.00%              
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Janpix Limited                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and commercial milestone payments   30,000,000   30,000,000 $ 30,000,000              
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Capella Biosciences Limited | Lonza Sales AG                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Research and development expense   42,060   116,960                
Maximum aggregate development and commercial milestone payments   5,400,000   5,400,000 5,400,000              
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | PearlRiver Bio GmbH | LDC | PearlRiver Bio GmbH License Agreement with Lead Discovery Center GmbH for Exon20                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments             $ 31,400,000 £ 27.0        
Maximum aggregate commercial milestone payments             17,400,000 15.0        
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | PearlRiver Bio GmbH | LDC | PearlRiver Bio GmbH License Agreement with Lead Discovery Center GmbH for C797                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments             9,100,000 7.8        
Maximum aggregate commercial milestone payments             $ 11,600,000 £ 10.0        
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Orexia | X-Chem                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments   24,800,000   24,800,000 24,800,000              
Maximum aggregate commercial milestone payments   60,000,000   60,000,000 60,000,000              
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Orexia | Heptares                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments                 $ 17,000,000 £ 12.6    
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Inexia | Heptares                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments                 $ 16,400,000 £ 12.1    
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Inexia | OptiNose                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Maximum aggregate development and regulatory milestone payments   8,000,000   8,000,000 8,000,000              
Maximum aggregate commercial milestone payments   $ 37,000,000   $ 37,000,000 $ 37,000,000