The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101   2,175,382 24,530 SH   SOLE   24,530 0 0
ABBOTT LABS COM 002824100   962,359 8,467 SH   SOLE   8,467 0 0
ABBVIE INC COM 00287Y109   3,468,094 19,045 SH   SOLE   19,045 0 0
ACHIEVE LIFE SCIENCES INC COM 004468500   990,106 217,845 SH   SOLE   217,845 0 0
ADVANCED MICRO DEVICES INC COM 007903107   791,088 4,383 SH   SOLE   4,383 0 0
AGNC INVT CORP COM 00123Q104   1,782,000 180,000 SH   SOLE   180,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108   6,205,776 245,676 SH   SOLE   245,676 0 0
ALIGN TECHNOLOGY INC COM 016255101   6,312,788 19,251 SH   SOLE   19,251 0 0
AMAZON COM INC COM 023135106   213,750 1,185 SH   SOLE   1,185 0 0
ANNALY CAPITAL MANAGEMENT IN COM NEW 035710839   1,835,108 93,200 SH   SOLE   93,200 0 0
APPLIED THERAPEUTICS INC COM 03828A101   19,159,034 2,817,505 SH   SOLE   2,817,505 0 0
ARDELYX INC COM 039697107   2,555,000 350,000 SH   SOLE   350,000 0 0
ARMOUR RESIDENTIAL REIT INC COM SHS 042315705   296,550 15,000 SH   SOLE   15,000 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210   242,618 250 SH   SOLE   250 0 0
ATHIRA PHARMA INC COM 04746L104   4,090,250 1,492,792 SH   SOLE   1,492,792 0 0
AVANTOR INC COM 05352A100   2,807,100 109,781 SH   SOLE   109,781 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   3,190,000 125,000 SH   SOLE   125,000 0 0
BIO-TECHNE CORP COM 09073M104   644,209 9,152 SH   SOLE   9,152 0 0
BLOCK INC CL A 852234103   249,257 2,947 SH   SOLE   2,947 0 0
BOSTON SCIENTIFIC CORP COM 101137107   4,277,748 62,458 SH   SOLE   62,458 0 0
CENTRAL & EASTERN EUROPE FD COM 153436100   384,827 40,423 SH   SOLE   40,423 0 0
COOPER COS INC COM 216648501   6,330,901 62,398 SH   SOLE   62,398 0 0
CYBIN INC COM 23256X100   206,750 500,000 SH   SOLE   500,000 0 0
DANAHER CORPORATION COM 235851102   312,899 1,253 SH   SOLE   1,253 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   2,891,297 175,018 SH   SOLE   175,018 0 0
EIGER BIOPHARMACEUTICALS INC COM NEW 28249U204   450,000 90,000 SH   SOLE   90,000 0 0
ELEVANCE HEALTH INC COM 036752103   2,716,631 5,239 SH   SOLE   5,239 0 0
ELI LILLY & CO COM 532457108   6,255,576 8,041 SH   SOLE   8,041 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   1,297,594 25,493 SH   SOLE   25,493 0 0
EXACT SCIENCES CORP COM 30063P105   4,421,705 64,027 SH   SOLE   64,027 0 0
FULCRUM THERAPEUTICS INC COM 359616109   6,381,733 676,031 SH   SOLE   676,031 0 0
GRAYSCALE BITCOIN TR BTC SHS REP COM UT 389637109   2,039,696 32,289 SH   SOLE   32,289 0 0
HCA HEALTHCARE INC COM 40412C101   471,945 1,415 SH   SOLE   1,415 0 0
HENRY SCHEIN INC COM 806407102   265,830 3,520 SH   SOLE   3,520 0 0
IDEXX LABS INC COM 45168D104   1,522,063 2,819 SH   SOLE   2,819 0 0
INSULET CORP COM 45784P101   2,567,401 14,979 SH   SOLE   14,979 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   12,909,763 32,348 SH   SOLE   32,348 0 0
ISHARES GOLD TR ISHARES NEW 464285204   1,814,832 43,200 SH   SOLE   43,200 0 0
ISHARES TR IBOXX INV CP ETF 464287242   485,348 4,456 SH   SOLE   4,456 0 0
ISHARES TR CORE US AGGBD ET 464287226   57,884,303 591,018 SH   SOLE   591,018 0 0
ISHARES TR RUSSELL 2000 ETF 464287655   275,114,460 1,308,200 SH Call SOLE   1,308,200 0 0
ISHARES TR 20 YR TR BD ETF 464287432   33,930,732 358,600 SH Put SOLE   358,600 0 0
ISHARES TR CORE S&P500 ETF 464287200   520,199,320 989,480 SH   SOLE   989,480 0 0
ISHARES TR 20 YR TR BD ETF 464287432   33,930,732 358,600 SH Call SOLE   358,600 0 0
ISHARES TR MBS ETF 464288588   2,070,208 22,400 SH   SOLE   22,400 0 0
JOHNSON & JOHNSON COM 478160104   3,843,226 24,295 SH   SOLE   24,295 0 0
KAYNE ANDERSON ENERGY INFRST COM 486606106   1,471,800 147,033 SH   SOLE   147,033 0 0
KURA ONCOLOGY INC COM 50127T109   1,706,400 80,000 SH   SOLE   80,000 0 0
KYMERA THERAPEUTICS INC COM 501575104   1,226,703 30,515 SH   SOLE   30,515 0 0
LEAP THERAPEUTICS INC COM NEW 52187K200   1,000,096 375,976 SH   SOLE   375,976 0 0
LEMONADE INC COM 52567D107   222,027 13,530 SH   SOLE   13,530 0 0
LIVANOVA PLC SHS G5509L101   481,811 8,613 SH   SOLE   8,613 0 0
LUMEN TECHNOLOGIES INC COM 550241103   780,000 500,000 SH   SOLE   500,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   6,220,430 23,294 SH   SOLE   23,294 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200   1,356,000 150,000 SH   SOLE   150,000 0 0
MASIMO CORP COM 574795100   1,443,829 9,832 SH   SOLE   9,832 0 0
MERCK & CO INC COM 58933Y105   6,289,133 47,663 SH   SOLE   47,663 0 0
MICROSOFT CORP COM 594918104   395,898 941 SH   SOLE   941 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   1,758,400 70,000 SH   SOLE   70,000 0 0
NATERA INC COM 632307104   1,158,707 12,669 SH   SOLE   12,669 0 0
NVIDIA CORPORATION COM 67066G104   932,474 1,032 SH   SOLE   1,032 0 0
OXFORD LANE CAP CORP COM 691543102   645,505 127,068 SH   SOLE   127,068 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   5,542,950 521,935 SH   SOLE   521,935 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304   4,008,154 72,141 SH   SOLE   72,141 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207   25,045,570 1,372,360 SH   SOLE   1,372,360 0 0
PURECYCLE TECHNOLOGIES INC COM 74623V103   6,620,817 1,064,440 SH   SOLE   1,064,440 0 0
REGENERON PHARMACEUTICALS COM 75886F107   2,935,594 3,050 SH   SOLE   3,050 0 0
REVVITY INC COM 714046109   2,721,495 25,919 SH   SOLE   25,919 0 0
RITHM CAPITAL CORP COM NEW 64828T201   399,528 35,800 SH   SOLE   35,800 0 0
ROYALTY PHARMA PLC SHS CLASS A G7709Q104   4,508,578 148,455 SH   SOLE   148,455 0 0
SAREPTA THERAPEUTICS INC COM 803607100   11,719,108 90,523 SH   SOLE   90,523 0 0
SHOCKWAVE MED INC COM 82489T104   4,866,540 14,945 SH   SOLE   14,945 0 0
SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BOND E 82889N723   104,937,160 4,896,741 SH   SOLE   4,896,741 0 0
SIMPLIFY EXCHANGE TRADED FUN STABLE INCM ETF 82889N640   79,714,553 3,179,679 SH   SOLE   3,179,679 0 0
SIMPLIFY EXCHANGE TRADED FUN ENHANCED INM ETF 82889N632   2,933,392 120,221 SH   SOLE   120,221 0 0
SIMPLIFY EXCHANGE TRADED FUN MANAGED FUTURES 82889N699   3,219,598 129,042 SH   SOLE   129,042 0 0
SIMPLIFY EXCHANGE TRADED FUN MULTI QIS ALTERN 82889N533   1,817,208 71,600 SH   SOLE   71,600 0 0
SIMPLIFY EXCHANGE TRADED FUN SHORT TERM TREA 82889N657   4,074,709 186,315 SH   SOLE   186,315 0 0
SIMPLIFY EXCHANGE TRADED FUN INTMD TERM TRSRY 82889N798   497,261 37,248 SH   SOLE   37,248 0 0
SIMPLIFY EXCHANGE TRADED FUN HIGH YIELD PLUS 82889N830   3,435,253 149,854 SH   SOLE   149,854 0 0
SIMPLIFY EXCHANGE TRADED FUN US EQUITY PLUS 82889N517   2,537,783 86,947 SH   SOLE   86,947 0 0
SIMPLIFY EXCHANGE TRADED FUN MARKET NEUTRAL 82889N541   6,701,450 287,000 SH   SOLE   287,000 0 0
SOLVENTUM CORP COM SHS 83444M101   426,515 6,133 SH   SOLE   6,133 0 0
SPDR GOLD TR GOLD SHS 78463V107   47,788,756 232,300 SH Call SOLE   232,300 0 0
SPDR SER TR S&P OILGAS EXP 78468R556   93,531,241 603,700 SH Call SOLE   603,700 0 0
SPDR SER TR S&P BIOTECH 78464A870   146,766,363 1,546,700 SH Call SOLE   1,546,700 0 0
STRYKER CORPORATION COM 863667101   1,821,200 5,089 SH   SOLE   5,089 0 0
SUTRO BIOPHARMA INC COM 869367102   678,000 120,000 SH   SOLE   120,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   1,793,021 75,337 SH   SOLE   75,337 0 0
TELESAT CORP CL A & CL B SHS 879512309   2,500,717 290,781 SH   SOLE   290,781 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   495,383 4,713 SH   SOLE   4,713 0 0
TESLA INC COM 88160R101   5,607,701 31,900 SH Call SOLE   31,900 0 0
TESLA INC COM 88160R101   302,359 1,720 SH   SOLE   1,720 0 0
THE CIGNA GROUP COM 125523100   8,820,796 24,287 SH   SOLE   24,287 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   4,807,188 8,271 SH   SOLE   8,271 0 0
TREVI THERAPEUTICS INC COM 89532M101   690,000 200,000 SH   SOLE   200,000 0 0
TSCAN THERAPEUTICS INC COM 89854M101   8,312,513 1,046,916 SH   SOLE   1,046,916 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   1,435,858 30,753 SH   SOLE   30,753 0 0
UNITEDHEALTH GROUP INC COM 91324P102   939,930 1,900 SH   SOLE   1,900 0 0
VEEVA SYS INC CL A COM 922475108   448,552 1,936 SH   SOLE   1,936 0 0
WESTERN ASSET EMERGING MKTS COM 95766A101   768,800 80,000 SH   SOLE   80,000 0 0
X4 PHARMACEUTICALS INC COM 98420X103   556,000 400,000 SH   SOLE   400,000 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   3,404,556 25,796 SH   SOLE   25,796 0 0