Gladstone Acquisition Corporation

1521 Westbranch Drive, Suite 100

McLean, Virginia 22102

March 16, 2021

VIA EDGAR

U.S. Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Re: Gladstone Acquisition Corporation

Registration Statement on Form S-1, as amended

Filed February 9, 2021

File No. 333-252916

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Gladstone Acquisition Corporation hereby requests acceleration of effectiveness of the above referenced Registration Statement so that it will become effective at 5:00 p.m. EST on March 18, 2021, or as soon as thereafter practicable.

Very truly yours,

/s/ David Gladstone

David Gladstone

Chief Executive Officer, President, Chief Investment Officer and Chairman

cc: Thomas Salley, Cooley LLP

John T. McKenna, Cooley LLP

Peter Byrne, Cooley LLP

Mitchell S. Nussbaum, Loeb & Loeb LLP

David J. Levine, Loeb & Loeb LLP