Equity Method Investments and Other Investments - Summary of Statements of operations (Detail) - USD ($) $ in Thousands		12 Months Ended
		Dec. 31, 2022	Dec. 31, 2021
Shedule Of Equity Method Investment Summarized Statement Of Operations [Line Items]
Revenue		$ 233	$ 20,376
Net loss		(157,417)	(174,244)
COMPASS [Member]
Shedule Of Equity Method Investment Summarized Statement Of Operations [Line Items]
Revenue		0	0
Loss from continuing operations		(110,403)	(83,221)
Net loss		(91,505)	(71,742)
GABA [member]
Shedule Of Equity Method Investment Summarized Statement Of Operations [Line Items]
Revenue		0	0
Loss from continuing operations		(5,867)	(4,216)
Net loss		$ (5,867)	(4,216)
Neuronasal [Member]
Shedule Of Equity Method Investment Summarized Statement Of Operations [Line Items]
Revenue			0
Loss from continuing operations	[1]		(985)
Net loss	[1]		$ (985)

[1] Results from operations for Neuronasal are through May 17, 2021 at which point the entity is consolidated.