The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 751 22,707 SH   DFND 1 22,707 0 0
2U INC COM 90214J101 8,956 214,929 SH   DFND 1 214,929 0 0
2U INC NOTE 2.250% 5/0 90214JAB7 6,845 4,150,000 SH   DFND 1 4,150,000 0 0
51JOB INC SPONSORED ADS 316827104 813 10,454 SH   DFND 1 10,454 0 0
ABBVIE INC COM 00287Y109 4,604 40,872 SH   DFND 1 40,872 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 60,495 964,058 SH   DFND 1 964,058 0 0
ACCELERON PHARMA INC COM 00434H108 56,117 447,180 SH   DFND 1 447,180 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 10,330 35,041 SH   DFND 2 35,041 0 0
ACE CONVERGENCE ACQU CORP *W EXP 09/30/202 G0083D104 149 15,000 SH   DFND 1 15,000 0 0
ACTIVISION BLIZZARD INC COM 00507V109 105,066 1,100,857 SH   DFND 1,2 1,100,857 0 0
ADDUS HOMECARE CORP COM 006739106 29,941 343,202 SH   DFND 1 343,202 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 302,116 515,874 SH   DFND 1 515,874 0 0
ADVANCED MICRO DEVICES INC COM 007903107 367,064 3,907,843 SH   DFND 1 3,907,843 0 0
AFFILIATED MANAGERS GROUP IN COM 008252108 22,487 145,819 SH   DFND 1 145,819 0 0
AFLAC INC COM 001055102 23,610 440,000 SH   DFND 1 440,000 0 0
AIR TRANSPORT SERVICES GRP I NOTE 1.125%10/1 00922RAB1 13,871 13,615,000 SH   DFND 1 13,615,000 0 0
AIRBNB INC COM CL A 009066101 133,106 869,181 SH   DFND   869,181 0 0
AKOYA BIOSCIENCES INC COM 00974H104 4,835 250,000 SH   DFND   250,000 0 0
ALCON AG ORD SHS H01301128 41,889 617,366 SH   DFND 1,2 617,366 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 174,312 768,639 SH   DFND 1 768,639 0 0
ALIGN TECHNOLOGY INC COM 016255101 83,791 137,137 SH   DFND 1 137,137 0 0
ALLEGHANY CORP MD COM 017175100 123,408 185,000 SH   DFND 1 185,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 55,650 328,282 SH   DFND 1 328,282 0 0
ALPHABET INC CAP STK CL A 02079K305 557,209 228,197 SH   DFND 1 228,197 0 0
ALPHABET INC CAP STK CL A 02079K305 9,767 4,000 SH Call DFND   4,000 0 0
ALPHABET INC CAP STK CL A 02079K305 9,767 4,000 SH Call DFND 1 4,000 0 0
ALPHABET INC CAP STK CL C 02079K107 609,484 243,179 SH   DFND 1,2 243,179 0 0
AMAZON COM INC COM 023135106 251,156 73,007 SH   DFND 1 73,007 0 0
AMEDISYS INC COM 023436108 17,644 72,038 SH   DFND 1 72,038 0 0
AMERICAN EXPRESS CO COM 025816109 9,636 58,317 SH   DFND 1 58,317 0 0
AMETEK INC COM 031100100 15,296 114,574 SH   DFND 1 114,574 0 0
AMGEN INC COM 031162100 29,458 120,854 SH   DFND 1 120,854 0 0
AMYRIS INC COM NEW 03236M200 1,198 73,202 SH   DFND 1 73,202 0 0
ANALOG DEVICES INC COM 032654105 40,232 233,688 SH   DFND 1 233,688 0 0
ANGIODYNAMICS INC COM 03475V101 2,649 97,626 SH   DFND 1 97,626 0 0
ANSYS INC COM 03662Q105 4,987 14,369 SH   DFND 1 14,369 0 0
ANTHEM INC COM 036752103 39,023 102,207 SH   DFND 1 102,207 0 0
AON PLC SHS CL A G0403H108 94,907 397,500 SH   DFND 1 397,500 0 0
APPLE INC COM 037833100 758,554 5,538,511 SH   DFND 1 5,538,511 0 0
APPLE INC COM 037833100 11,025 80,500 SH Call DFND 1 80,500 0 0
APPLIED MATLS INC COM 038222105 282,699 1,985,246 SH   DFND 1 1,985,246 0 0
APTARGROUP INC COM 038336103 77,661 551,414 SH   DFND   551,414 0 0
APTIV PLC SHS G6095L109 126,526 804,210 SH   DFND 1 804,210 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 8,578 2,583,731 SH   DFND 1 2,583,731 0 0
ARCH CAP GROUP LTD ORD G0450A105 238,179 6,116,553 SH   DFND 1 6,116,553 0 0
ARCO PLATFORM LTD COM CL A G04553106 7,222 235,561 SH   DFND 1 235,561 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 45,917 1,682,543 SH   DFND 1 1,682,543 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,991 29,192 SH   DFND 1 29,192 0 0
ARES CAPITAL CORP COM 04010L103 5,210 265,972 SH   DFND 1 265,972 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 824 9,945 SH   DFND 1 9,945 0 0
ATLASSIAN CORP PLC CL A G06242104 10,827 42,150 SH   DFND 1 42,150 0 0
ATRICURE INC COM 04963C209 24,766 312,190 SH   DFND 1 312,190 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 18,808 2,794,673 SH   DFND 1 2,794,673 0 0
AVALARA INC COM 05338G106 76,864 475,055 SH   DFND 1 475,055 0 0
AVANTOR INC COM 05352A100 101,729 2,864,802 SH   DFND 1 2,864,802 0 0
AXON ENTERPRISE INC COM 05464C101 29,387 166,218 SH   DFND 1 166,218 0 0
AXONICS INC COM 05465P101 35,606 561,516 SH   DFND 1 561,516 0 0
BANDWIDTH INC NOTE 0.250% 3/0 05988JAB9 1,627 1,000,000 SH   DFND 1 1,000,000 0 0
BANK OF NT BUTTERFIELD&SON L SHS NEW G0772R208 6,734 189,950 SH   DFND 1 189,950 0 0
BAXTER INTL INC COM 071813109 20,453 254,071 SH   DFND 1 254,071 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 10,885 3,500,000 SH   DFND 1 3,500,000 0 0
BERKLEY W R CORP COM 084423102 96,759 1,300,000 SH   DFND 1 1,300,000 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 77,818 280,000 SH   DFND 1 280,000 0 0
BILIBILI INC SPONS ADS REP Z 090040106 10,642 87,341 SH   DFND 1 87,341 0 0
BIO RAD LABS INC CL A 090572207 127,350 197,659 SH   DFND 1 197,659 0 0
BIOGEN INC COM 09062X103 43,284 125,000 SH   DFND 1 125,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 86,958 895,732 SH   DFND 1 895,732 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 10,430 125,000 SH   DFND 1 125,000 0 0
BK OF AMERICA CORP COM 060505104 23,461 569,025 SH   DFND 1 569,025 0 0
BLACKLINE INC COM 09239B109 26,600 239,057 SH   DFND 1 239,057 0 0
BLACKSTONE GROUP INC COM 09260D107 12,197 125,558 SH   DFND 1 125,558 0 0
BOOKING HOLDINGS INC COM 09857L108 12,240 5,594 SH   DFND 1 5,594 0 0
BOSTON SCIENTIFIC CORP COM 101137107 21,373 499,836 SH   DFND 1 499,836 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 24,980 373,843 SH   DFND 1 373,843 0 0
BRUKER CORP COM 116794108 704 9,265 SH   DFND 1 9,265 0 0
CANADIAN NAT RES LTD COM 136385101 25,887 644,855 SH   DFND 1 644,855 0 0
CANNAE HLDGS INC COM 13765N107 17,394 512,960 SH   DFND   512,960 0 0
CASTLE BIOSCIENCES INC COM 14843C105 2,109 28,761 SH   DFND 1 28,761 0 0
CATALENT INC COM 148806102 52,759 487,966 SH   DFND 1 487,966 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 16,720 500,000 SH   DFND 1 500,000 0 0
CENTENE CORP DEL COM 15135B101 48,956 671,280 SH   DFND 1 671,280 0 0
CERENCE INC COM 156727109 11,128 104,284 SH   DFND 1 104,284 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 1,281 50,000 SH   DFND 1 50,000 0 0
CERUS CORP COM 157085101 4,194 709,718 SH   DFND 1 709,718 0 0
CHANGE HEALTHCARE INC UNIT 99/99/9999 15912K209 80,854 1,063,452 SH   DFND 1 1,063,452 0 0
CHEGG INC COM 163092109 117,966 1,419,395 SH   DFND 1 1,419,395 0 0
CHEMED CORP NEW COM 16359R103 4,930 10,389 SH   DFND 1 10,389 0 0
CHUBB LIMITED COM H1467J104 189,176 1,190,238 SH   DFND 1 1,190,238 0 0
CITIGROUP INC COM NEW 172967424 40,828 577,069 SH   DFND 1 577,069 0 0
CITIZENS FINL GROUP INC COM 174610105 14,250 310,666 SH   DFND 1 310,666 0 0
CLOUDFLARE INC CL A COM 18915M107 33,720 318,597 SH   DFND 1 318,597 0 0
COGENT BIOSCIENCES INC COM 19240Q201 8,110 1,000,000 SH   DFND 1 1,000,000 0 0
COGNEX CORP COM 192422103 26,883 319,851 SH   DFND 1 319,851 0 0
COLFAX CORP COM 194014106 21,242 463,701 SH   DFND 1 463,701 0 0
CONFLUENT INC CLASS A COM 20717M103 238 5,000 SH   DFND 1 5,000 0 0
CONMED CORP COM 207410101 1,555 11,314 SH   DFND 1 11,314 0 0
COOPER COS INC COM NEW 216648402 50,092 126,408 SH   DFND 1 126,408 0 0
COUPA SOFTWARE INC COM 22266L106 69,237 264,154 SH   DFND 1 264,154 0 0
COUPA SOFTWARE INC NOTE 0.375% 6/1 22266LAF3 15,294 13,200,000 SH   DFND 1 13,200,000 0 0
COURSERA INC COM 22266M104 4,353 110,032 SH   DFND   110,032 0 0
CRITEO S A SPONS ADS 226718104 8,799 194,544 SH   DFND 1 194,544 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 174,710 695,199 SH   DFND 1 695,199 0 0
CSG SYS INTL INC NOTE 4.250% 3/1 126349AF6 20,712 20,000,000 SH   DFND 1 20,000,000 0 0
CURIS INC COM NEW 231269200 16,140 2,000,000 SH   DFND 1 2,000,000 0 0
CVS HEALTH CORP COM 126650100 4,833 57,917 SH   DFND 1 57,917 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 59,559 457,194 SH   DFND 1 457,194 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 356 81,630 SH   DFND 1 81,630 0 0
CYTOKINETICS INC COM NEW 23282W605 48,072 2,429,100 SH   DFND 1 2,429,100 0 0
DATADOG INC NOTE 0.125% 6/1 23804LAB9 5,348 4,000,000 SH   DFND 1 4,000,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 14,644 400,000 SH   DFND 1 400,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 3,828 48,798 SH   DFND 1 48,798 0 0
DEXCOM INC COM 252131107 9,686 22,685 SH   DFND 1 22,685 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 40,485 1,084,813 SH   DFND 1 1,084,813 0 0
DOCUSIGN INC COM 256163106 158,052 565,341 SH   DFND 1 565,341 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 108,840 1,107,337 SH   DFND 1 1,107,337 0 0
DOLLAR GEN CORP NEW COM 256677105 4,401 20,336 SH   DFND 2 20,336 0 0
DUN & BRADSTREET HLDGS INC COM 26484T106 3,259 152,508 SH   DFND 2 152,508 0 0
EAST WEST BANCORP INC COM 27579R104 9,658 134,722 SH   DFND 1 134,722 0 0
EBAY INC. COM 278642103 31,788 452,755 SH   DFND 1 452,755 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 8,448 81,567 SH   DFND 1 81,567 0 0
EMERSON ELEC CO COM 291011104 19,125 198,723 SH   DFND 1 198,723 0 0
ENCOMPASS HEALTH CORP COM 29261A100 74,371 953,110 SH   DFND 1 953,110 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 6,496 140,029 SH   DFND 1 140,029 0 0
ENVISTA HOLDINGS CORPORATION COM 29415F104 23,954 554,351 SH   DFND 1 554,351 0 0
EPAM SYS INC COM 29414B104 10,051 19,670 SH   DFND 1 19,670 0 0
EQUIFAX INC COM 294429105 3,786 15,808 SH   DFND 1 15,808 0 0
ESSENT GROUP LTD COM G3198U102 108,442 2,412,500 SH   DFND 1 2,412,500 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 556 6,367 SH   DFND 1 6,367 0 0
ETSY INC COM 29786A106 91,938 446,647 SH   DFND 1 446,647 0 0
EURONET WORLDWIDE INC COM 298736109 1,421 10,500 SH   DFND 2 10,500 0 0
EVERBRIDGE INC COM 29978A104 190,401 1,399,185 SH   DFND 1 1,399,185 0 0
EVEREST RE GROUP LTD COM G3223R108 63,822 253,250 SH   DFND 1 253,250 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 13,033 10,500,000 SH   DFND 1 10,500,000 0 0
EXELIXIS INC COM 30161Q104 52,223 2,866,242 SH   DFND 1 2,866,242 0 0
FACEBOOK INC CL A 30303M102 642,811 1,848,698 SH   DFND 1 1,848,698 0 0
FACEBOOK INC CL A 30303M102 9,388 27,000 SH Call DFND 1 27,000 0 0
FERGUSON PLC NEW SHS G3421J106 4,674,379 286,770 SH   DFND   286,770 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 5,694 40,193 SH   DFND 2 40,193 0 0
FIREEYE INC NOTE 0.875% 6/0 31816QAF8 3,970 3,500,000 SH   DFND 1 3,500,000 0 0
FIRST AMERN FINL CORP COM 31847R102 37,410 600,000 SH   DFND 1 600,000 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 5,925 31,658 SH   DFND 1 31,658 0 0
FISERV INC COM 337738108 24,551 229,683 SH   DFND 1 229,683 0 0
FIVE9 INC COM 338307101 62,353 340,000 SH   DFND 1 340,000 0 0
GENERAL DYNAMICS CORP COM 369550108 2,203 11,700 SH   DFND 2 11,700 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 26,265 750,000 SH   DFND 1 750,000 0 0
GLOBUS MED INC CL A 379577208 59,833 771,737 SH   DFND 1 771,737 0 0
GOLUB CAP BDC INC COM 38173M102 1,355 87,850 SH   DFND 1 87,850 0 0
GUARDANT HEALTH INC COM 40131M109 81,909 659,544 SH   DFND 1 659,544 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 403 5,509 SH   DFND 1 5,509 0 0
HEALTHEQUITY INC COM 42226A107 715 8,879 SH   DFND 1 8,879 0 0
HILL-ROM HLDGS INC COM 431475102 19,947 175,604 SH   DFND 1 175,604 0 0
HOLOGIC INC COM 436440101 16,547 248,000 SH   DFND 1 248,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 132,121 1,410,942 SH   DFND 1 1,410,942 0 0
HUBSPOT INC COM 443573100 229,300 393,500 SH   DFND 1 393,500 0 0
HUBSPOT INC NOTE 0.375% 6/0 443573AD2 2,122 1,000,000 SH   DFND   1,000,000 0 0
ICON PLC SHS G4705A100 21,928 106,081 SH   DFND 1 106,081 0 0
IGM BIOSCIENCES INC COM 449585108 1,759 21,144 SH   DFND 1 21,144 0 0
ILLUMINA INC COM 452327109 875 1,850 SH   DFND 1 1,850 0 0
INCYTE CORP COM 45337C102 43,327 515,005 SH   DFND 1 515,005 0 0
INSMED INC COM PAR $.01 457669307 26,651 936,438 SH   DFND 1 936,438 0 0
INSPIRE MED SYS INC COM 457730109 1,065 5,511 SH   DFND 1 5,511 0 0
INSULET CORP NOTE 0.375% 9/0 45784PAK7 5,458 4,000,000 SH   DFND 1 4,000,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 15,321 94,624 SH   DFND 1 94,624 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 18,581 156,536 SH   DFND 1 156,536 0 0
INTERSECT ENT INC COM 46071F103 220 12,856 SH   DFND 1 12,856 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 2,386 58,444 SH   DFND 1 58,444 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 12,839 13,961 SH   DFND 1 13,961 0 0
IONIS PHARMACEUTICALS INC NOTE 0.125%12/1 462222AB6 19,320 20,677,000 SH   DFND 1 20,677,000 0 0
IQIYI INC NOTE 2.000% 4/0 46267XAD0 20,608 22,000,000 SH   DFND 1 22,000,000 0 0
IQIYI INC NOTE 3.750%12/0 46267XAB4 100 100,000 SH   DFND 1 100,000 0 0
IQIYI INC SPONSORED ADS 46267X108 539 34,590 SH   DFND 1 34,590 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 6,335 1,054,006 SH   DFND 1 1,054,006 0 0
JAMES RIV GROUP LTD COM G5005R107 33,768 900,000 SH   DFND 1 900,000 0 0
JAZZ INVESTMENTS I LTD NOTE 2.000% 6/1 472145AF8 8,678 6,500,000 SH   DFND   6,500,000 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 26,646 150,000 SH   DFND 1 150,000 0 0
JD.COM INC SPON ADR CL A 47215P106 27,672 346,724 SH   DFND 1 346,724 0 0
JOHNSON & JOHNSON COM 478160104 196,539 1,193,023 SH   DFND 1 1,193,023 0 0
JPMORGAN CHASE & CO COM 46625H100 35,655 229,231 SH   DFND 1 229,231 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 14,788 617,180 SH   DFND 1 617,180 0 0
KLA CORP COM NEW 482480100 5,198 16,032 SH   DFND 1 16,032 0 0
KURA ONCOLOGY INC COM 50127T109 7,298 350,000 SH   DFND 1 350,000 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 8,397 30,439 SH   DFND 1,2 30,439 0 0
LANTHEUS HLDGS INC COM 516544103 539 19,504 SH   DFND 1 19,504 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 123,573 2,199,586 SH   DFND 1 2,199,586 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 12,525 259,792 SH   DFND 1 259,792 0 0
LILLY ELI & CO COM 532457108 8,826 38,452 SH   DFND 1 38,452 0 0
LITTELFUSE INC COM 537008104 23,561 92,473 SH   DFND 1 92,473 0 0
LIVANOVA PLC SHS G5509L101 3,005 35,732 SH   DFND 1 35,732 0 0
LIVE NATION ENTERTAINMENT IN NOTE 2.500% 3/1 538034AQ2 1,401 1,000,000 SH   DFND 1 1,000,000 0 0
LIVEPERSON INC COM 538146101 72,386 1,144,622 SH   DFND 1 1,144,622 0 0
LIVERAMP HLDGS INC COM 53815P108 5,533 118,101 SH   DFND 1 118,101 0 0
LOGITECH INTL S A SHS H50430232 70,896 603,814 SH   DFND 1 603,814 0 0
LUMENTUM HLDGS INC NOTE 0.500%12/1 55024UAD1 7,045 6,500,000 SH   DFND 1 6,500,000 0 0
LYFT INC CL A COM 55087P104 6,383 105,540 SH   DFND 1 105,540 0 0
M & T BK CORP COM 55261F104 5,245 36,095 SH   DFND 1 36,095 0 0
MARKEL CORP COM 570535104 153,141 129,047 SH   DFND 1 129,047 0 0
MARSH & MCLENNAN COS INC COM 571748102 191,647 1,362,288 SH   DFND 1 1,362,288 0 0
MARVELL TECHNOLOGY INC COM 573874104 231,864 3,975,034 SH   DFND   3,975,034 0 0
MASIMO CORP COM 574795100 5,240 21,612 SH   DFND 1 21,612 0 0
MASTERCARD INCORPORATED CL A 57636Q104 96,208 263,519 SH   DFND 1 263,519 0 0
MATCH GROUP INC NEW COM 57667L107 140,182 869,344 SH   DFND   869,344 0 0
MAXLINEAR INC COM 57776J100 7,928 186,592 SH   DFND   186,592 0 0
MEDPACE HLDGS INC COM 58506Q109 670 3,795 SH   DFND 1 3,795 0 0
MEDTRONIC PLC SHS G5960L103 36,274 292,223 SH   DFND 1 292,223 0 0
MERCADOLIBRE INC COM 58733R102 16,410 10,534 SH   DFND 1 10,534 0 0
MERIDIAN BIOSCIENCE INC COM 589584101 892 40,235 SH   DFND 1 40,235 0 0
MERIT MED SYS INC COM 589889104 44,501 688,231 SH   DFND 1 688,231 0 0
MICRON TECHNOLOGY INC COM 595112103 166,623 1,960,730 SH   DFND 1 1,960,730 0 0
MICROSOFT CORP COM 594918104 918,460 3,390,403 SH   DFND 1,2 3,390,403 0 0
MIRATI THERAPEUTICS INC COM 60468T105 9,526 58,973 SH   DFND 1 58,973 0 0
MODIVCARE INC COM 60783X104 48,994 288,084 SH   DFND 1 288,084 0 0
MOHAWK INDS INC COM 608190104 13,713 71,351 SH   DFND 1 71,351 0 0
MOLINA HEALTHCARE INC COM 60855R100 72,667 287,154 SH   DFND 1 287,154 0 0
MONOLITHIC PWR SYS INC COM 609839105 115,148 308,337 SH   DFND 1 308,337 0 0
MORPHIC HLDG INC COM 61775R105 8,609 150,000 SH   DFND   150,000 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 48,593 750,000 SH   DFND 1 750,000 0 0
NATERA INC COM 632307104 6,015 52,979 SH   DFND 1 52,979 0 0
NETEASE INC SPONSORED ADS 64110W102 18,767 162,835 SH   DFND 1 162,835 0 0
NETFLIX INC COM 64110L106 23,642 44,758 SH   DFND 1 44,758 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 15,958 163,973 SH   DFND 1 163,973 0 0
NEURONETICS INC COM 64131A105 20,025 1,250,000 SH   DFND 1 1,250,000 0 0
NOVAVAX INC COM NEW 670002401 19,108 90,000 SH   DFND 1 90,000 0 0
NUTANIX INC NOTE 1/1 67059NAB4 10,693 10,100,000 SH   DFND 1 10,100,000 0 0
NVIDIA CORPORATION COM 67066G104 476,384 595,405 SH   DFND 1 595,405 0 0
OAK STR HEALTH INC COM 67181A107 1,695 28,936 SH   DFND   28,936 0 0
OCULAR THERAPEUTIX INC COM 67576A100 536 37,790 SH   DFND 1 37,790 0 0
OKTA INC NOTE 0.375% 6/1 679295AF2 7,881 6,300,000 SH   DFND 1 6,300,000 0 0
OMNICELL COM COM 68213N109 720 4,752 SH   DFND 1 4,752 0 0
ONCOCYTE CORP COM 68235C107 382 66,529 SH   DFND   66,529 0 0
OPTIMIZERX CORP COM NEW 68401U204 629 10,168 SH   DFND 1 10,168 0 0
OPTION CARE HEALTH INC COM NEW 68404L201 49,197 2,249,506 SH   DFND 1 2,249,506 0 0
ORACLE CORP COM 68389X105 4,504 57,866 SH   DFND 2 57,866 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 2,661 4,700 SH   DFND 2 4,700 0 0
OWENS & MINOR INC NEW COM 690732102 1,188 28,054 SH   DFND 1 28,054 0 0
PACIRA BIOSCIENCES INC COM 695127100 1,054 17,368 SH   DFND 1 17,368 0 0
PACWEST BANCORP DEL COM 695263103 8,972 217,978 SH   DFND   217,978 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 5,250 93,887 SH   DFND 1 93,887 0 0
PALO ALTO NETWORKS INC NOTE 0.375% 6/0 697435AF2 16,244 11,900,000 SH   DFND 1 11,900,000 0 0
PAYPAL HLDGS INC COM 70450Y103 296,012 1,015,547 SH   DFND 1 1,015,547 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 104,077 839,195 SH   DFND 1 839,195 0 0
PENUMBRA INC COM 70975L107 2,443 8,913 SH   DFND 1 8,913 0 0
PG&E CORP UNIT 99/99/9999 69331C140 81,096 800,000 SH   DFND 1 800,000 0 0
PHOENIX NEW MEDIA LTD SPONSORED ADS 71910C103 143 91,947 SH   DFND 1 91,947 0 0
PINDUODUO INC NOTE 12/0 722304AC6 12,900 12,500,000 SH   DFND   12,500,000 0 0
PINTEREST INC CL A 72352L106 100,896 1,277,968 SH   DFND 1 1,277,968 0 0
PNC FINL SVCS GROUP INC COM 693475105 5,805 30,430 SH   DFND 1 30,430 0 0
POWER INTEGRATIONS INC COM 739276103 61,120 744,822 SH   DFND 1 744,822 0 0
PRICELINE GRP INC NOTE 0.900% 9/1 741503AX4 5,443 5,000,000 SH   DFND 1 5,000,000 0 0
PROASSURANCE CORP COM 74267C106 27,300 1,200,000 SH   DFND 1 1,200,000 0 0
PROGRESSIVE CORP COM 743315103 60,890 620,000 SH   DFND 1 620,000 0 0
PROGYNY INC COM 74340E103 544 9,223 SH   DFND 1 9,223 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 5,350 119,203 SH   DFND 1 119,203 0 0
QIAGEN NV SHS NEW N72482123 2,384 46,522 SH   DFND 1 46,522 0 0
QORVO INC COM 74736K101 61,043 312,000 SH   DFND 1 312,000 0 0
QUALCOMM INC COM 747525103 133,190 931,853 SH   DFND 1 931,853 0 0
QUALTRICS INTL INC COM CL A 747601201 14,414 376,834 SH   DFND   376,834 0 0
QUIDEL CORP COM 74838J101 1,220 9,525 SH   DFND 1 9,525 0 0
QUOTIENT LTD SHS G73268107 33,676 9,251,653 SH   DFND 1 9,251,653 0 0
R1 RCM INC COM 749397105 4,969 223,437 SH   DFND 1 223,437 0 0
RAPID7 INC NOTE 2.250% 5/0 753422AD6 1,664 1,000,000 SH   DFND 1 1,000,000 0 0
RECRO PHARMA INC COM 75629F109 513 222,222 SH   DFND 1 222,222 0 0
REGENERON PHARMACEUTICALS COM 75886F107 83,781 150,000 SH   DFND 1 150,000 0 0
REINSURANCE GRP OF AMERICA I COM NEW 759351604 65,550 575,000 SH   DFND 1 575,000 0 0
RENAISSANCERE HLDGS LTD COM G7496G103 128,797 865,453 SH   DFND 1,2 865,453 0 0
REVANCE THERAPEUTICS INC COM 761330109 34,226 1,154,734 SH   DFND 1 1,154,734 0 0
RINGCENTRAL INC NOTE 3/0 76680RAF4 9,984 9,000,000 SH   DFND 1 9,000,000 0 0
RLI CORP COM 749607107 28,762 275,000 SH   DFND 1 275,000 0 0
ROBLOX CORP CL A 771049103 79,486 883,373 SH   DFND   883,373 0 0
ROCKWELL AUTOMATION INC COM 773903109 16,642 58,183 SH   DFND 1 58,183 0 0
S&P GLOBAL INC COM 78409V104 19,369 47,189 SH   DFND 1 47,189 0 0
SABRE CORP COM 78573M104 9,557 765,804 SH   DFND 1 765,804 0 0
SALESFORCE COM INC COM 79466L302 105,553 432,118 SH   DFND 1 432,118 0 0
SEA LTD SPONSORD ADS 81141R100 32,577 118,634 SH   DFND 1 118,634 0 0
SEAGATE TECHNOLOGY HLDNGS PL ORD SHS G7997R103 126,860 1,442,740 SH   DFND 1 1,442,740 0 0
SEAGEN INC COM 81181C104 59,205 375,000 SH   DFND 1 375,000 0 0
SEASPINE HLDGS CORP COM 81255T108 16,816 819,901 SH   DFND 1 819,901 0 0
SENSATA TECHNOLOGIES HLDG PL SHS G8060N102 17,236 297,321 SH   DFND 2 297,321 0 0
SERVICENOW INC COM 81762P102 96,835 176,207 SH   DFND 1 176,207 0 0
SHIFT TECHNOLOGIES INC CL A 82452T107 12,192 1,421,033 SH   DFND   1,421,033 0 0
SHOCKWAVE MED INC COM 82489T104 438 2,310 SH   DFND 1 2,310 0 0
SHOPIFY INC CL A 82509L107 30,726 21,031 SH   DFND 1 21,031 0 0
SHOPIFY INC NOTE 0.125%11/0 82509LAA5 6,535 5,000,000 SH   DFND   5,000,000 0 0
SIGNATURE BK NEW YORK N Y COM 82669G104 8,967 36,502 SH   DFND 1 36,502 0 0
SILICON LABORATORIES INC NOTE 0.625% 6/1 826919AD4 18,700 13,441,000 SH   DFND 1 13,441,000 0 0
SLR INVESTMENT CORP COM 83413U100 5,471 293,498 SH   DFND 1 293,498 0 0
SMARTSHEET INC COM CL A 83200N103 114,952 1,589,492 SH   DFND 1 1,589,492 0 0
SNAP INC CL A 83304A106 244,159 3,583,198 SH   DFND 1 3,583,198 0 0
SNOWFLAKE INC CL A 833445109 83,879 346,894 SH   DFND   346,894 0 0
SONOS INC COM 83570H108 11,542 327,612 SH   DFND   327,612 0 0
SPIRIT AIRLS INC NOTE 1.000% 5/1 848577AB8 1,916 2,000,000 SH   DFND   2,000,000 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 35,589 129,139 SH   DFND 1 129,139 0 0
SQUARE INC CL A 852234103 87,046 357,037 SH   DFND 1 357,037 0 0
SS&C TECHNOLOGIES HLDGS INC COM 78467J100 26,131 362,630 SH   DFND 1 362,630 0 0
SSR MNG INC NOTE 2.500% 4/0 784730AB9 15,008 12,339,000 SH   DFND 1 12,339,000 0 0
STELLANTIS N.V SHS N82405106 18,490 884,415 SH   DFND 2 884,415 0 0
STERIS PLC SHS USD G8473T100 71,522 346,691 SH   DFND 1 346,691 0 0
STITCH FIX INC COM CL A 860897107 3,892 64,542 SH   DFND   64,542 0 0
STONECO LTD COM CL A G85158106 18,677 278,515 SH   DFND   278,515 0 0
STRYKER CORPORATION COM 863667101 8,030 30,917 SH   DFND 1 30,917 0 0
SUMMIT THERAPEUTICS INC COM 86627T108 51,936 6,961,913 SH   DFND   6,961,913 0 0
SUPERNUS PHARMACEUTICALS INC NOTE 0.625% 4/0 868459AD0 13,293 13,453,000 SH   DFND 1 13,453,000 0 0
SURGERY PARTNERS INC COM 86881A100 46,902 704,017 SH   DFND 1 704,017 0 0
SVB FINANCIAL GROUP COM 78486Q101 9,450 16,984 SH   DFND 1 16,984 0 0
SYNEOS HEALTH INC CL A 87166B102 65,334 730,067 SH   DFND 1 730,067 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 14,008 116,582 SH   DFND 1,2 116,582 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 18,205 102,842 SH   DFND 1 102,842 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 1,821 18,694 SH   DFND 1 18,694 0 0
TAYLOR MORRISON HOME CORP COM 87724P106 18,278 691,818 SH   DFND 1 691,818 0 0
TE CONNECTIVITY LTD REG SHS H84989104 114,057 843,554 SH   DFND 1 843,554 0 0
TELADOC HEALTH INC NOTE 1.250% 6/0 87918AAF2 6,746 6,000,000 SH   DFND 1 6,000,000 0 0
TELEFLEX INCORPORATED COM 879369106 52,631 130,991 SH   DFND 1 130,991 0 0
TENABLE HLDGS INC COM 88025T102 64,594 1,562,134 SH   DFND   1,562,134 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 1,666 24,870 SH   DFND 1 24,870 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 29,375 58,230 SH   DFND 1 58,230 0 0
T-MOBILE US INC COM 872590104 44,373 306,383 SH   DFND 1 306,383 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 14,870 191,873 SH   DFND 1 191,873 0 0
TRAVELERS COMPANIES INC COM 89417E109 110,967 741,210 SH   DFND 1 741,210 0 0
TREACE MED CONCEPTS INC COM 89455T109 8,017 256,450 SH   DFND   256,450 0 0
TREVENA INC COM 89532E109 181 106,900 SH   DFND 1 106,900 0 0
TRIPADVISOR INC COM 896945201 144,433 3,583,942 SH   DFND 1 3,583,942 0 0
TWILIO INC CL A 90138F102 147,822 375,030 SH   DFND 1 375,030 0 0
TWITTER INC COM 90184L102 144,446 2,099,205 SH   DFND 1 2,099,205 0 0
UBER TECHNOLOGIES INC COM 90353T100 8,179 163,183 SH   DFND 1 163,183 0 0
UBS GROUP AG SHS H42097107 11,684 787,775 SH   DFND 1 787,775 0 0
UNIQURE NV SHS N90064101 1,031 33,476 SH   DFND 1 33,476 0 0
UNITED RENTALS INC COM 911363109 34,177 107,134 SH   DFND 1 107,134 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 8,940 49,829 SH   DFND 1 49,829 0 0
UNITEDHEALTH GROUP INC COM 91324P102 24,906 62,197 SH   DFND 1 62,197 0 0
UNITY SOFTWARE INC COM 91332U101 23,664 215,459 SH   DFND   215,459 0 0
UPSTART HLDGS INC COM 91680M107 7,494 60,000 SH   DFND 1 60,000 0 0
US BANCORP DEL COM NEW 902973304 9,516 167,038 SH   DFND 1 167,038 0 0
US FOODS HLDG CORP COM 912008109 35,387 922,490 SH   DFND 1 922,490 0 0
VERICEL CORP COM 92346J108 552 10,515 SH   DFND 1 10,515 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 5,886 900,000 SH   DFND 1 900,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 60,489 300,000 SH   DFND 1 300,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 3,916 65,000 SH   DFND 1 65,000 0 0
VIAVI SOLUTIONS INC NOTE 1.000% 3/0 925550AB1 3,533 2,500,000 SH   DFND 1 2,500,000 0 0
VISA INC COM CL A 92826C839 64,638 276,445 SH   DFND 1 276,445 0 0
WEBSTER FINL CORP CONN COM 947890109 10,090 189,164 SH   DFND 1 189,164 0 0
WELLS FARGO CO NEW COM 949746101 33,382 737,076 SH   DFND 1 737,076 0 0
WESTERN DIGITAL CORP. COM 958102105 96,172 1,351,300 SH   DFND 1 1,351,300 0 0
WORKDAY INC CL A 98138H101 58,421 244,707 SH   DFND 1 244,707 0 0
YANDEX N V SHS CLASS A N97284108 7,028 99,341 SH   DFND 1 99,341 0 0
Y-MABS THERAPEUTICS INC COM 984241109 19,804 585,921 SH   DFND 1 585,921 0 0
ZAI LAB LTD ADR 98887Q104 29,986 169,422 SH   DFND 1 169,422 0 0
ZENDESK INC COM 98936J101 199,259 1,380,487 SH   DFND 1 1,380,487 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 25,672 482,558 SH   DFND 1 482,558 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 84,425 690,765 SH   DFND 1 690,765 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 61,174 380,389 SH   DFND 1 380,389 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 169,410 437,718 SH   DFND 1 437,718 0 0
ZUORA INC COM CL A 98983V106 23,549 1,365,148 SH   DFND 1 1,365,148 0 0