Jefferies LLC 520 Madison Avenue New York, New York 10022 Cowen and Company, LLC 599 Lexington Avenue New York, New York 10022 Credit Suisse Securities (USA) LLC Eleven Madison Avenue New York, New York 10010 William Blair & Company, L.L.C. 150 North Riverside Plaza Chicago, Illinois 60606

VIA EDGAR    

March 23, 2021    

United States Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attention: Kasey Robinson

Suzanne Hayes

Re: Ikena Oncology, Inc.

Acceleration Request for Registration Statement on Form S-1

File No. 333-253919

Dear Ms. Robinson,

Pursuant to Rule 460 of the General Rules and Regulations under the Securities Act of 1933, as amended (the “Act”), we, as representatives of the several underwriters, wish to advise you that approximately 1,725 copies of the preliminary prospectus included in the above referenced registration statement (the “Registration Statement”) were distributed during the period March 22, 2021 through the date hereof, to prospective underwriters, institutions, dealers and others.

We have been informed by the participating underwriters that they will comply with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934, as amended.

In accordance with Rule 461 of the Act, we hereby join in the request of Ikena Oncology, Inc. for acceleration of the effective date of the Registration Statement so that it becomes effective at 4:00 p.m. Eastern Time on March 25, 2021, or as soon thereafter as practicable.

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Very truly yours,
By:	JEFFERIES LLC
By:	/s/ Charlie Glazer
	Name: Charlie Glazer
	Title: Managing Director
By:	COWEN AND COMPANY, LLC
By:	/s/ Mariel A. Healy
	Name: Mariel A. Healy
	Title: Managing Director
By:	CREDIT SUISSE SECURITIES (USA) LLC
By:	/s/ Rebecca Kotkin
	Name: Rebecca Kotkin
	Title: Director
By:	WILLIAM BLAIR & COMPANY, L.L.C.
By:	/s/ Steve Maletzky
	Name: Steve Maletzky
	Title: Partner, Head of Equity Capital Markets

[Signature page to Acceleration Request Letter]