Exhibit 32.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER AND

CHIEF FINANCIAL OFFICER PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

This Certification is being filed pursuant to 18 U.S.C. Section 1350, as adopted by Section 906 of the Sarbanes-Oxley Act of 2002. This Certification is included solely for the purposes of complying with the provisions of Section 906 of the Sarbanes-Oxley Act and is not intended to be used for any other purpose. In connection with the accompanying Quarterly Report on Form 10-Q of Coya Therapeutics, Inc. (the “Company”) for the period ended June 30, 2023 (the “Quarterly Report”), each of Howard Berman, as Chief Executive Officer, and David Snyder, as Chief Financial Officer, certifies in his capacity as such officer of the Company, that to such officer’s knowledge:

1)The Quarterly Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2)The information contained in the Quarterly Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: August 8, 2023	By:	/s/ Howard Berman
		Howard Berman
		Chief Executive Officer
		(Principal Executive Officer)

Dated: August 8, 2023	By:	/s/ David Snyder
		David Snyder
		Chief Financial Officer
		(Principal Financial and Accounting Officer)

This certification shall not be deemed “filed” for any purpose, nor shall it be deemed to be incorporated by reference into any filing under the Securities Act of 1933 or the Exchange Act.