Exhibit 99.1

RULE 438 CONSENT

In accordance with Rule 438 under the Securities Act of 1933, as amended, the undersigned hereby consents to being named as a prospective director of Big Cypress Acquisition Corp. (which will be renamed SAB Biotherapeutics, Inc. after the business combination) in the Registration Statement on Form S-4 filed by Big Cypress Acquisition Corp. with the Securities and Exchange Commission.

/s/ Edward Sullivan

Name: Edward Sullivan

Date: July 2, 2021

/s/ Christine Hamilton

Name: Christine Hamilton

Date: July 2, 2021

/s/ William Polvino

Name: William Polvino

Date: July 2, 2021

/s/ Mervyn Turner

Name: Mervyn Turner

Date: July 2, 2021

/s/ David Link

Name: David Link

Date: July 2, 2021