phvs-ex993

Unaudited condensed consolidated statements of profit or loss and other comprehensive income

			Three months ended June 30						Six months ended June 30
			2021			2020			2021			2020
	Notes		€						€
Research and development expenses		3		(8,060,599	)		(4,331,843	)		(16,132,053	)		(6,735,245	)
General and administrative expenses		4		(4,664,726	)		(1,393,890	)		(8,436,415	)		(2,236,450	)
Total operating expenses				(12,725,325	)		(5,725,733	)		(24,568,468	)		(8,971,695	)

Net foreign exchange income/(loss)		6		(2,474,483	)		(19,691	)		3,344,373			(50,264	)
Loss before income tax				(15,199,808	)		(5,745,424	)		(21,224,095	)		(9,021,959	)

Income taxes		7		(2,965	)		—			(21,554	)		—
Loss for the period				(15,202,773	)		(5,745,424	)		(21,245,649	)		(9,021,959	)

Other comprehensive income/(Loss)
Exchange gains arising on translation of foreign operations				426			(1,987	)		1,675			(1,987	)

Total comprehensive loss attributable to:
Equity holders of the Company				(15,202,347	)		(5,747,411	)		(21,243,974	)		(9,023,946	)

Loss per share attributable to the equity holders of the Company during the periods
Basic and diluted loss per share:	19			(0.94	)		(1.19	)		(1.32	)		(1.86	)

The accompanying notes are an integral part of these unaudited condensed consolidated interim financial statements.

			June 30, 2021			December 31, 2020
	Notes		€			€
Assets
Non-current assets
Property, plant and equipment		8		75,059			48,503
Right of use assets		9		285,743			—
Current assets
Deferred tax assets		7		102,574			99,339
Receivables		10		712,765			569,578
Other current assets		11		4,231,468			1,753,327
Cash and cash equivalents		12		224,317,740			98,628,871
Total assets				229,725,349			101,099,618

Equity and liabilities
Equity
Share capital		13		3,975,432			235,693
Share premium				278,435,529			138,034,580
Other reserves				5,757,542			1,979,875
Currency translation reserve				(2,690	)		(4,365	)
Accumulated loss				(65,937,407	)		(44,459,954	)
Total equity				222,228,406			95,785,829

Long term liabilities
Non-current lease liability	9			189,285			—
Current liabilities
Trade and other payables		14		3,343,006			846,952
Accrued liabilities		15		3,964,652			4,466,837
Total liabilities				7,496,943			5,313,789
Total equity and liabilities				229,725,349			101,099,618

The accompanying notes are an integral part of these unaudited condensed consolidated interim financial statements.

			Share capital		Share premium			Other reserves			Currency translation reserve			Accumulated losses			Total Equity
	Notes		€		€			€			€			€			€
Balance at January 1, 2020				130,962		36,624,697			392,139			—			(18,474,250	)		18,673,548
Total comprehensive loss				—		—			—			—			(3,276,355	)		(3,276,355	)
Share-based payments		18		—		—			293,717			—			—			293,717
Balance at March 31, 2020				130,962		36,624,697			685,856			—			(21,750,605	)		15,690,910
Total comprehensive loss				—		—			—			—			(5,745,424	)		(5,745,424	)
Currency translation reserve												(1,987	)					(1,987	)
Share-based payments		18		—		—			366,415						—			366,415
Balance at June 30, 2020				130,962		36,624,697			1,052,271			(1,987	)		(27,496,029	)		10,309,914
Balance at January 1, 2021				235,693		138,034,580			1,979,875			(4,365	)		(44,459,954	)		95,785,829
Total comprehensive loss				—		—			—			—			(6,042,877	)		(6,042,877	)
Increase in par value	13			2,592,621		(2,592,621	)		—			—			—			—
Issue of share capital		13		1,141,329		156,014,570			—			—			—			157,155,899
Transaction costs on issue of shares				—		(13,154,360	)		—			—			—			(13,154,360	)
Currency translation reserve				—		—			—			1,249			—			1,249
Shares issued upon exercise of RSUs	18			1,709					(35,161	)					(231,803	)		(265,255	)
Share-based payments		18		—		—			2,096,610									2,096,610
Balance at March 31, 2021				3,971,352		278,302,169			4,041,324			(3,116	)		(50,734,634	)		235,577,095
Total comprehensive loss				—		—			—			—			(15,202,773	)		(15,202,773	)
Currency translation reserve				—		—			—			426			—			426
Shares issued upon exercise of options	18			4,080		133,360			(56,520	)		—			—			80,920
Share-based payments		18		—		—			1,772,738		0				—			1,772,738
Balance at June 30, 2021				3,975,432		278,435,529			5,757,542			(2,690	)		(65,937,407	)		222,228,406

The accompanying notes are an integral part of these unaudited condensed consolidated interim financial statements.

			2021			2020
	Notes		€			€
Operating activities
Loss before tax				(21,224,095	)		(9,021,959	)
Non-cash adjustments to reconcile loss before tax to net cash flows from operations:
Share-based payment expense		18		3,869,348			660,132
Depreciation expense	4			15,048			2,663
Net foreign exchange (gain)/loss	6			(3,503,986	)		19,321
Finance costs		6		159,613			30,943

Changes in working capital:
Decrease/(Increase) in receivables				(143,187	)		149,093
Decrease in other current assets				(3,919,580	)		(462,575	)
Increase in trade and other payables				2,367,811			2,591,199
Increase in accrued liabilities				481,628			99,996
Paid interest				(134,418	)		(33,972	)
Taxes paid				(27,095	)		—
Net cash flows used in operating activities				(22,058,913	)		(5,965,159	)

Investing activities
Purchase of property, plant and equipment		8		(33,554	)		(18,429	)
Net cash flows used in investing activities				(33,554	)		(18,429	)

Financing activities
Proceeds from issue of shares		13		157,236,819			—
Transaction costs on issue of shares				(12,925,547	)		—
				(5,012	)		—
Net cash flows provided by financing activities				144,306,260			—

Net increase (decrease) in cash and cash equivalents				122,213,793			(5,983,588	)
Cash and cash equivalents at the beginning of the period				98,628,871			20,326,372
Effect of exchange rate changes				3,475,076			(14,306	)
Cash and cash equivalents at the end of the period		12		224,317,740			14,328,478

The accompanying notes are an integral part of these unaudited condensed consolidated interim financial statements

This section provides general corporate and group information about Pharvaris N.V. (formerly Pharvaris B.V.) and its subsidiaries.

Pharvaris N.V. was incorporated on September 30, 2015 and is based in Leiden, the Netherlands.

The address of its registered office is J.H. Oortweg 21, Leiden. It has been registered at the Chamber of Commerce under file number 64239411.

The unaudited condensed consolidated interim financial statements of Pharvaris N.V. (the “Company” or “Pharvaris”) and its subsidiaries (collectively, “The Group”) as at June 30, 2021 and December 31, 2020, and for the three and six months ended June 30, 2021 and 2020 were authorised for issue in accordance with a resolution of the directors on July 30, 2021.

The unaudited condensed consolidated interim financial statements of the Group include:

The ultimate parent company of the Group is Pharvaris N.V., which is based in the Netherlands.

On May 12, 2021, the Company announced the expansion of their leadership team through the appointment of Dr W. Souverijns, as Chief Community Engagement & Commercial Officer.

On June 29, 2021, the Company's general meeting of shareholders appointed Ms. Viviane Monges as Non-Executive Director and on June 30, 2021 the Board of Directors elected Ms. Monges as chair of the Audit Committee.

The unaudited condensed consolidated interim financial statements of the Group have been prepared in accordance with International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB).

The unaudited condensed consolidated interim financial statements have been prepared in accordance with IAS 34 Interim Financial Reporting and should be read in conjunction with the Group’s annual consolidated financial statements as at and for the year ended December 31, 2020 (“last annual financial statements”). These unaudited condensed consolidated interim financial statements do not include all the information required for a complete set financial statements prepared in accordance with IFRS as issued by the IASB. However, selected explanatory notes are included to explain events and transactions that are significant to an understanding of the changes in the Group’s financial position and performance since the last annual financial statements.

The unaudited condensed consolidated interim financial statements have been prepared on a historical cost basis. Unless otherwise stated, the unaudited condensed consolidated interim financial statements are presented in euros and all values are rounded to the nearest EUR (€), except per share amounts.

Pharvaris is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for rare diseases with significant unmet need, initially focused on angioedema and other bradykinin-mediated diseases. These therapies will need to go through clinical development trials to achieve regulatory approval for commercialization. Therefore, Pharvaris is incurring annual research and development and other operating costs and has no revenues to date (as is typical in the biotech industry for development stage and early commercial stage companies). As such, Pharvaris anticipates on-going negative operating cash flows for several years before the company has a product candidate ready for commercialization, if proven successful. This makes the Group dependent on external capital sources, debt capital and equity capital. The Group is currently fully financed by equity capital.

As of June 30, 2021 and December 31, 2020 the Group had cash of €224.3 million and €98.6 million, respectively. The Group incurred net losses of €21.2 million in the six months ended June 30, 2021 and €9.0 million in the same period in 2020 and negative operating cash flows of €22.1 million and €6.0 million in the six months ended June 30, 2021 and the six months ended June 30, 2020 respectively.

The Group does not expect positive operating cash flows in the foreseeable future and remains dependent on additional financings to fund its research and development expenses, general and administrative expenses and financing costs. However, the Group believes that the available cash balances are sufficient to execute the Group’s operating plan and strategies and to meet the anticipated working capital requirements and settle all expected liabilities for a period of at least twelve months after the signing date of these unaudited condensed consolidated interim financial statements. Accordingly, unaudited condensed consolidated interim financial statements have been prepared on a going concern basis.

The outbreak of a novel strain of the coronavirus, specifically identified as “COVID-19”, has spread globally. COVID-19 is a virus causing potentially deadly respiratory tract infections and has impacted the global economy. In March 2020, the World Health Organization declared COVID-19 a pandemic.

The Group has taken appropriate measures to protect the safety of the employees and continuously monitors and evaluates the situation regarding COVID-19. The COVID-19 outbreak has delayed, and may continue to delay, enrollment in our clinical trials. The Group experienced an approximate two-month delay in starting the enrollment of our now completed Phase 1 multiple ascending dose study of PHA121 in healthy volunteers as a result of COVID-19.

The spread of an infectious disease, including COVID-19, may also result in the inability of our suppliers to deliver components or raw materials, and the inability of our CDMOs to provide supplies of our product candidates for our planned clinical trials, on a timely basis or at all. Further, it may impact the ability of our CROs, including non-clinical CROs, to provide services to support our clinical program. The extent to which the COVID-19 pandemic impacts our business will depend on future developments, which are uncertain and cannot be predicted, including new information which may emerge concerning the severity of the COVID-19 pandemic and the actions to contain COVID-19 or treat its impact, among others. If we are unable to meet our milestones it might jeopardize our funding opportunities.

In addition, the COVID-19 pandemic has already caused, and is likely to result in further, significant disruptions and uncertainties in global financial markets, which may reduce our ability to access capital on favorable terms or at all. A recession, depression or other sustained adverse market event resulting from the spread of COVID-19 could also materially and adversely affect our business and the value of our ordinary shares.

The Group continuously monitors the situation regarding COVID-19, and the possible impact on the CROs, contract manufacturing organizations and clinical sites performing research and development activities for the Group. All efforts are made to develop alternatives to limit the impact of COVID-19 going forward.

The ultimate impact of the COVID-19 pandemic is uncertain and subject to change. Management does not expect that COVID-19 will have a material adverse effect on the financial condition or liquidity of the Company.

In preparing these unaudited condensed consolidated interim financial statements, management has made judgements and estimates that affect the application of accounting policies and the reported amounts of assets and liabilities, income and expense. Actual results may differ from these estimates.

The significant judgements made by management in applying the Group’s accounting policies and the key sources of estimation uncertainty were the same as those described in the last annual financial statements, except for the share options granted, refer to note 18.

The accounting policies applied in these unaudited condensed consolidated interim financial statements are the same as those applied in the consolidated financial statements as at and for the year ended December 31, 2020, except for:

Lease policies and disclosure are related to leases entered into in the second quarter of 2021.

All leases are accounted for by recognizing a right-of-use asset and a lease liability except for:

Lease liabilities are measured at the present value of the contractual payments due to the lessor over the lease term, with the Group’s incremental borrowing rate on commencement of the lease used.

On initial recognition, the carrying value of the lease liability also includes:

Right of use assets are initially measured at the amount of the lease liability, reduced for any lease incentives received, and increased for:

Subsequent to initial measurement lease liabilities increase as a result of interest charged at a constant rate on the balance outstanding and are reduced for lease payments made. Right-of-use assets are amortised on a straight-line basis over the remaining term of the lease.

When the Group revises its estimate of the term of any lease, it adjusts the carrying amount of the lease liability to reflect the payments to make over the revised term, which are discounted using a revised discount rate.

	For the three months ended June 30						For the six months ended June 30
	2021			2020			2021			2020
	€						€
Personnel expenses (Note 5)		(1,759,669	)		(449,846	)		(3,768,165	)		(906,234	)
Clinical expenses		(3,496,223	)		(1,517,962	)		(6,761,928	)		(2,697,525	)
Non-clinical expenses		(1,181,660	)		(789,610	)		(2,143,713	)		(1,144,499	)
Manufacturing costs		(1,601,980	)		(1,495,580	)		(2,920,172	)		(1,907,267	)
License costs		—			—			(500,000	)		—
Intellectual Property costs		(21,067	)		(78,845	)		(38,075	)		(79,720	)
		(8,060,599	)		(4,331,843	)		(16,132,053	)		(6,735,245	)

Development expenses are currently not capitalized but are recorded in the unaudited condensed consolidated statements of profit or loss and other comprehensive income because the recognition criteria for capitalization are not met.

Clinical expenses include costs of conducting and managing our sponsored clinical trials, including clinical investigator cost, costs of clinical sites, and costs for CRO’s assisting with our clinical development programs.

Non-clinical expenses include costs of our outsourced discovery, medicinal chemistry, preclinical and nonclinical development studies.

Manufacturing expenses include costs related to manufacturing of active pharmaceutical ingredients and manufacturing of the products used in our clinical trials and research and development activities.

License costs consist of a milestone payment of €500,000 which was paid to AnalytiCon upon commencement of Phase 2 development.

	For the three months ended June 30						For the six months ended June 30
	2021			2020			2021			2020
	€						€
Personnel expenses (Note 5)		(1,795,721	)		(453,479	)		(3,036,786	)		(611,927	)
Consulting fees		(161,559	)		(221,307	)		(390,872	)		(478,700	)
Professional fees		(324,793	)		(249,065	)		(1,132,706	)		(379,183	)
Accounting, tax and auditing fees		(648,626	)		(320,271	)		(1,086,756	)		(403,599	)
Facilities, communication & office expenses		(1,510,566	)		(131,709	)		(2,462,147	)		(234,696	)
Travel expenses		(2,563	)		742			(3,357	)		(22,044	)
Other expenses		(220,898	)		(18,801	)		(323,791	)		(106,301	)
		(4,664,726	)		(1,393,890	)		(8,436,415	)		(2,236,450	)

In 2021 the Group entered into a number of lease arrangements, which were assessed to be short-term leases (with a lease term of 12 months equaling its non-cancellable period). The total outflow for the leases in the first six months of 2021 was €98,565 (2020: €66,914) and is included in the Facilities, communication & office expenses line. The total outflow for the leases in the second quarter of 2021 amounts to €55,913 (2020: €29,792).

Depreciation expense of €15,048 (2020: €2,663) related to property, plant and equipment and leases and is included in the other expenses line for the six months ended June 30, 2021. For the second quarter of 2021 a total of €11,987 (2020: €1,558) depreciation charge was included in Other expenses.

The average number of staff (in FTEs) employed by the Group in the six months ended June 30, 2021 was 17 (2020: 7).

The tax expenses over the six months ended June 30, 2021 relate to the Company's US subsidiary as the result of a cost-plus agreement between the US entity and Group's principal entity resulting in a taxable profit in the United States of America.

Reconciliation of income tax benefit at statutory tax rate and the income tax expense as reported in the unaudited condensed consolidated statement of profit or loss and other comprehensive income is as follows:

	For the three months ended June 30						For the six months ended June 30
	2021			2020			2021			2020
	€			€			€			€
Loss before income tax		(15,199,807	)		(5,745,424	)		(21,224,095	)		(9,021,959	)
Income tax benefit at statutory income tax rate of 25%		(3,799,952	)		(1,436,356	)		(5,306,024	)		(2,255,490	)
Temporary differences for which no deferred tax assets/liabilities have been recognized		184,629			(275,280	)		162,580			211,474
Non-deductible expenses for tax purposes		96,125			(70,893	)		587			3,686
Current year losses for which no deferred tax asset has been recognized		2,361,695			1,543,047			1,992,455			1,805,953
Differences in overseas tax rates		1,160,468			820,236			3,171,956			815,131
Impact of rate differences on opening deferred tax balances		—			(580,754	)		—			(580,754	)
Income tax expense		2,965			—			21,554			—

The effect of current year losses for which no DTA has been recognized includes the offsetting effect from the derecognition of losses reported through equity/ consolidated statement of profit or loss and other comprehensive income.

The differences in the overseas tax rates are due to the lower tax rate in Switzerland and the higher tax rate in the USA compared to the statutory income tax rate in the Netherlands.

The effective tax rate is 0.1% for the six months ended June 30, 2021(2020: 0%).

Pharvaris N.V. is the head of the fiscal unity including Pharvaris Netherlands B.V. and Pharvaris Holdings B.V.

The Group has tax loss carry-forwards of approximately €74.7 million as of June 30, 2021 (2020: €12.5 million), that are available for offsetting against future taxable profits of the companies in which the losses arose. In 2021, the Dutch tax law was revised and as result of the revision, the carry forward losses can be offset indefinitely. Under Swiss law, losses can be offset against future income or capital gains for seven years.

Tax loss carry-forwards incurred in current and prior years will expire as follows:

The DTA on losses not recognized partly relates to an effect through P&L and partly to an effect through equity.

Deferred taxes have been recognized to the extent that management concludes that there is sufficient probability as per IAS 12 that there will be future taxable profits available in the foreseeable future against which the unused tax losses can be utilized.

Deferred tax assets relating to losses carried forward have not been recognized, and deferred tax assets on deductible temporary differences in excess of deferred tax liabilities on taxable temporary differences have not been recognized in the consolidated statement of profit or loss and other comprehensive income.

As a result thereof, the total unrecognized deferred tax assets from temporary differences amounts to €22.7 million (2020: €0.9 million) and relates to various temporary differences on intangibles in the Netherlands and Switzerland.

	Intangible assets			Non current provisions and liabilities			Fixed assets			Total
Deferred tax assets	€			€			€
At January 1, 2021		1,964,583			99,339			—			2,063,922
(Charged)/credited
- Profit or loss		(56,944	)		(99,339	)		—			(156,283	)
- Currency translation differences					—						—
At June 30, 2021		1,907,639			—			—			1,907,639

Deferred tax liability
At January 1, 2021		—			(1,964,583	)		—			(1,964,583	)
(Charged)/credited
- Profit or loss		—			222,285			(76,970	)		145,315
- Currency translation differences		—			15,271			(1,095	)		14,176
At June 30, 2021		—			(1,727,027	)		(78,065	)		(1,805,092	)
Net deferred tax assets at June 30, 2021											102,547

	Notes		Office equipment			Total
			€			€
Balance at December 31, 2020
Opening net book amount				48,503			48,503
Additions				33,554			33,554
Depreciation expense		4		(6,998	)		(6,998	)
Balance at June 30, 2021				75,059			75,059

Balance at June 30, 2021
Cost				90,007			90,007
Accumulated depreciation				(14,948	)		(14,948	)
Net book amount				75,059			75,059

During the six months ended June 30, 2021, the Group acquired assets with a cost of €33,554 (December 31, 2020: €42,977). The acquisitions during the six months ended June 30, 2021 and the year ended December 31, 2020 were related to equipment, tools and installations.

The following table provides information about the Group’s right-of-use assets:

The following table provides information about the Group’s lease liabilities at June 30, 2021:

The lease agreement started on June 1, 2021 and has a lease term of three years. The average incremental borrowing rate applied to the lease liabilities was 1.5% during the six months ended June 30, 2021(2020: n/a). Cash outflows related to leases during the six months ended June 30, 2021 and 2020 were €5,012 and €0, respectively.

Prepayments mainly relates to prepaid insurance, sign-on bonus to personnel, prepaid R&D expenses and rent.

Other assets per December 31, 2020, mainly consist of deferred transaction costs related to Group’s IPO, which was completed in February, 2021. The balance was reclassified to the share premium at completion of the IPO. Other assets per June 30, 2021 consist of rent deposit paid.

Cash and cash equivalents comprise of cash in bank and are not subject to any restriction.

On June 30, 2021, the Company’s authorized share capital amounted to €14,100,000 divided into 58,750,000 ordinary shares and 58,750,000 preferred shares, each with a nominal value of €0.12. As at June 30, 2021, a total number of ordinary shares issued was 33,128,593 (2020: 23,569,276). On June 30, 2021, the issued share capital totalled to €3,975,432 (2020: €235,693).

On February 5, 2021, the Company became public by listing its ordinary shares on the Nasdaq Stock Exchange. On the same date all Preferred shares A, Preferred shares B and Preferred shares C were automatically converted to ordinary shares and 9,511,075 shares were issued. Together with the issuance of the ordinary shares, the par value of each share was increased from €0.01 to €0.12.

The Group’s risk management activities are the same as disclosed in note 16 of the consolidated financial statements as of and for the year ended December 31, 2020, except for the following:

The Company is exposed to foreign exchange risk arising from various currency exposures, primarily with respect to the U.S. Dollar. We received the proceeds from our initial public offering in February 2021 in U.S. Dollars. We seek to minimize our exchange rate risk by maintaining cash positions in the currencies in which we expect to incur the majority of our future expenses and we make payments from those positions.

The Group has adopted an investment policy with the primary purpose of preserving capital, fulfilling its liquidity needs and diversifying the risks associated with cash. This investment policy establishes minimum ratings for institutions with which the Group holds cash, also ensuring that a negative interest rate is not paid.

Fair values of cash and cash equivalents, trade receivables, trade payables, and other current liabilities approximate their carrying amounts largely due to the short-term maturities of these instruments.

In 2016, the Company implemented an Equity Incentive Plan (the “Plan”) in order to advance the interests of the Company’s shareholders by enhancing the Company’s ability to attract, retain and motivate persons who are expected to make important contributions to the Company and by providing such persons with performance-based incentives that are intended to better align the interests of such persons with those of the Company’s shareholders. This plan has been superseded by the 2021 long term incentive plan (“LTIP”).

Set out below is an overview of changes in the Stock Options and Restricted Stock Units (“RSUs”) during the six months ended June 30, 2021.

On January 1, 2021 the Company granted a total of 107,000 stock options to members of key management with an exercise price of €7.25 per share with a final exercise date of December 31, 2030 unless forfeited or exercised on an earlier date. On February 4, 2021, a total of 873,000 stock options were granted to members of key management with an exercise price of $20 per share with a final exercise date of February 3, 2031 unless forfeited or exercised on an earlier date. 25% of the aggregate number of share options shall vest on the 12-month anniversary of the vesting commencement date, and thereafter 1/48th of the aggregate number of share options shall vest on each subsequent monthly anniversary of the vesting commencement date until either the option is fully vested or the option holders’ continuous service terminates.

On February 3, 2020 132,000 stock options were granted to a member of key management with an exercise price of €2.38 per share with a final exercise date of February 2, 2030 unless forfeited or exercised on an earlier date. Each of 2020, 2021, 2022 is a performance period. The Board needs to determine the performance goals for the related performance period before September 30 of the respective year. On July 13, 2020 the performance goals for 2020 were determined and the fair value of the 44,000 stock options was reassessed for the stock options subject to the performance goals for 2020. The Board resolved to modify the terms and conditions related to the performance options effective June 25, 2021. The performance condition was released and the vesting period was changed from vesting on December 31, 2021 of the second tranche and December 31, 2022 of the third tranche to monthly vesting starting from February 3, 2020. Each month, 1/48 of the options will vest, with final vesting on February 4, 2024.

Since this modification did not change Management’s best estimate of when the options will be exercised, no incremental fair value was granted.

On June 25, 2021, a total of 14,000 stock options were granted to a member of key management with an exercise price of $20 per share with a final exercise date of February 3, 2031 unless forfeited or exercised on an earlier date. 25% of the aggregate number of share options shall vest on February 3, 2022 and thereafter 1/48th of the aggregate number of share options shall vest on each subsequent monthly anniversary of the vesting commencement date until either the option is fully vested or the option holders’ continuous service terminates.

During the three months ended June 30, 2021 a total of 51,188 RSUs were granted to employees that joined the Group in the same period. The RSUs shall vest equally over a four-year period on each of the four anniversaries of the vesting start date until either the RSUs are fully vested or the RSUs holders’ continuous service terminates.

The fair value of the RSUs is determined based on the share value per ordinary share at the grant date. The grant dates were April 1, 2021, May 1, 2021 and June 1, 2021. The share closing price was $27.95, $25.02 and $20.65 at April 1,2021, May 3, 2021 and June 1, 2021 respectively. For the May 1, 2021 grants the share price of May 3, 2021 is used, as May 1, 2021 was a not a business day.

For the six months ended June 30, 2021, the Group recognized €3,869,347 of share-based payment expense in the unaudited condensed consolidated statement of income or loss and other comprehensive income (six month ended June 30, 2020: €660,132).

As of June 30, 2021, a total number of 764.517 of the granted stock options have vested (June 30, 2020: nil), of which 337,667 stock options are exercisable (June 30, 2020: nil)

The inputs used in the measurement of the fair value per option at each grant/ measurement date using the Black-Scholes formula (including the related number of options and the fair value of the options) were as follows:

	June 25, 2021			June 25, 2021			February 4, 2021			January 1, 2021
Number of options		14,000			88,000			873,000			107,000
Fair value of the options	€	10.90		€	13.73		€	11.88		€	6.08
Fair value of the ordinary shares	€	15.46		€	15.46		€	16.69		€	7.25
Exercise price	€	16.74		€	2.38		€	16.69		€	7.25
Expected volatility (%)		85	%		85	%		85	%		85	%
Expected life (years)		6.1			4.6			6.1			6.0
Risk-free interest rate (%)		1.2	%		(0.5	)%		0.8	%		(0.6	)%
Expected dividend yield		—			—			—			—

Expected volatility is based on an evaluation of the historical volatilities of comparable listed biotech-companies over the most recent historical period that commensurate with the expected option life. The expected life is based on Management’s best estimate of when the options will be exercised. The risk-free interest rate is based on the yield on German government Strip bonds or US Governments bonds depending on whether the exercise price is in euros or in US Dollars, with tenure equal to the expected life. The expected dividend yield is zero considering the stage of the Group.

On February 5, 2021, the Company’s ordinary shares began trading on the Nasdaq Stock Exchange. From that date, the shares of the Company were traded at a regulated stock exchange. For the determination of the fair value on the grant date, the closing price on the grant date is used.

Reference is made to Note 5 for allocation of expenses in lines of the unaudited condensed consolidated statement of income or loss and other comprehensive income.

Basic and diluted loss per share is calculated by dividing the loss attributable to equity holders of the Company by the weighted average number of issued and outstanding ordinary shares during the three and six months ended June 30, 2021 and June 30, 2020.

The Company’s potential dilutive securities have been excluded from the computation of diluted net loss per share attributable to ordinary stockholders as the effect of including them would be antidilutive.

Potentially dilutive shares that were not included in the diluted per share calculations because they would be anti-dilutive were 5,242,850 Series A preferred shared and 3,003,391 Series B preferred shares as of June 30, 2020. All the preferred shares were converted to common shares on the date that the Company completed its listing at Nasdaq. All the options outstanding as of June 30, 2021 and 2020 were anti-dilutive and were not included in the diluted per share calculations.

There are no material claims known to management related to the activities of the Group.

The Group’s contractual obligations and commitments as of June 30, 2021 amounted to €15,379,000, (December 31, 2020: €11,351,000) primarily related to research and development commitments. All of which are due within 3 years.

The Group had no contingent liabilities and no contingent assets as at June 30, 2021 and at June 30, 2020, respectively.

Note 1.2 provides information about the Group’s structure, including details of the subsidiaries and the holding company. The following provides the total amount of transactions that have been entered into with related parties for the relevant financial period.

Dr Knolle, who has served as Chief Scientific Officer and Chief Operating Officer since its inception, is a member of the board of Charité CRO. The Group has entered into a service contract with Charité CRO according to which Charité CRO provides services supporting research for the Group. The aggregate transaction value of the transactions with Charité CRO during the six months ended June 30, 2021 and 2020 were €608 and €500,660, respectively. The outstanding balances with Charité CRO amounts to €nil and €3,692 on June 30, 2021 and December 31, 2020, respectively.

An amount of € 328,000 of the short-term employee benefits is capitalized in the unaudited condensed consolidated statements of financial position as at June 30, 2020 and is recognized in the Group’s statements of profit or loss and other comprehensive income in the period between July 2020 and June 2021.

A total of 994,000 stock options are granted to key management during the six months ended June 30, 2021. Refer to note 18 for disclosures on the share-based payments.

The Group engages several management entities for the purpose of providing key management services to the Group. The aggregate value of transactions related to key management personnel, or entities which they control were €1,738,383 and €929,904 in the six months ended June 30, 2021 and 2020, respectively and €974,125 and €472,870 in the three months ended June 30, 2021 and 2020 respectively.

The outstanding balances payable to key management personnel, or entities which they control, as per June 30, 2021 and December 31, 2020 were €362,489 and €57,920, respectively.

The Company has evaluated subsequent events through July 30, 2021, which is the date the condensed consolidated interim financial statements were authorized for issuance, and did not identify any significant event after reporting period that needs to be disclosed.

Signatories to the unaudited condensed consolidated interim financial statements

Unaudited condensed consolidated statements of profit or loss and other comprehensive income	3

Unaudited condensed consolidated statements of financial position	4

Unaudited condensed consolidated statements of changes in equity	5

Unaudited condensed consolidated statements of cash flows	6

Notes to the unaudited condensed consolidated interim financial statements	7

		Country of	% of equity interest as June 30,
Name	Legal seat	incorporation	2021	2020
Pharvaris Holdings B.V.	Leiden	The Netherlands	100%	100%
Pharvaris Netherlands B.V.	Leiden	The Netherlands	100%	100%
Pharvaris GmbH	Zug	Switzerland	100%	100%
Pharvaris, Inc.	Delaware	United States of America	100%	100%

	For the three months ended June 30						For the six months ended June 30
	2021			2020			2021			2020
	€						€
Wages and salaries		(1,606,969	)		(474,732	)		(2,618,645	)		(752,995	)
Pension charges		(51,327	)		(24,125	)		(81,289	)		(29,533	)
Other social security charges		(124,356	)		(38,053	)		(235,669	)		(75,501	)
Share-based payments		(1,772,738	)		(366,415	)		(3,869,348	)		(660,132	)
		(3,555,390	)		(903,325	)		(6,804,951	)		(1,518,161	)

	For the three months ended June 30						For the six months ended June 30
	2021			2020			2021			2020
	€									€
Foreign exchange differences		(2,401,910	)		(211	)		3,503,986			(19,321	)
Interest expenses over bank balances		(69,552	)		(16,291	)		(151,764	)		(27,433	)
Other finance expenses		(3,021	)		(3,189	)		(7,849	)		(3,510	)
		(2,474,483	)		(19,691	)		3,344,373			(50,264	)

Year	Switzerland		Netherlands		Tax losses
	€ million		€ million		€ million
2027		33.9		—		33.9
2028		22.0		—		22.0
Unlimited		—		18.8		18.8
Total carry-forward losses		55.9		18.8		74.7

	June 30, 2021			December 31, 2020
Office lease		(285,918	)		—
Total lease liability		(285,918	)		—
Current portion		(96,633	)		—
Non-current portion		(189,285	)		—

	June 30, 2021		December 31, 2020
	€		€
VAT receivables		712,724		569,578
		712,724		569,578

	June 30, 2021		December 31, 2020
	€		€
Prepayments		4,225,841		540,701
Other assets		5,627		1,212,626
		4,231,468		1,753,327

	June 30, 2021		December 31, 2020
Ordinary shares		33,128,593		4,850,000
Preferred shares A		—		5,242,850
Preferred shares B		—		7,650,147
Preferred shares C		—		5,826,279
		33,128,593		23,569,276

	June 30, 2021		December 31, 2020
	€		€
Consulting and accounting fees		1,097,963		1,505,304
Clinical expenses		889,000		635,820
Manufacturing expenses		576,000		970,587
Non-clinical expenses		238,250		421,429
Personnel expenses		1,086,781		875,238
Other expenses		76,658		58,459
		3,964,652		4,466,837

	Stock Options					RSUs
	Outstanding options			Weighted average exercise price		Outstanding RSUs			Weighted average purchase price
Outstanding December 31, 2020		1,465,295		€	1.85		153,595		€	0.01
Granted		994,000		€	15.66		51,188		€	-
Exercised		(34,000	)	€	2.38		(25,295	)	€	0.01
Forfeited		(35,000	)	€	16.67		—		€	-
Outstanding June 30, 2021		2,390,295		€	8.09		179,488		€	-

	For the three months ended June 30,						For the six months ended June 30,
	2021			2020			2021			2020
	€						€
Loss attributable to equity holders of the Company		(15,202,347	)		(5,747,411	)		(21,243,974	)		(9,023,946	)
Weighted average number of ordinary shares outstanding		16,154,350			4,850,000			16,154,350			4,850,000
Basic and diluted loss per share		(0.94	)		(1.19	)		(1.32	)		(1.86	)


B.A.E. Modig	M. Kleijwegt


R.P.L. Droller	R.H. Glassman


D.P. Meeker	J.G.C.P. Schikan