April 27, 2021

VIA EDGAR

U.S. Securities and Exchange Commission

Office of Life Sciences

Division of Corporation Finance

Mail Stop 4561

100 F Street, N.E.

Washington, D.C. 20549

Attention:  David Gessert and Jeffrey Gabor

Re: Vaccitech plc Acceleration Request for Registration Statement on Form S-1 (File No. 333-255158)

Ladies and Gentlemen:

In connection with the above-captioned Registration Statement and offering, we, the representatives of the underwriters (the “Representatives”), wish to advise you that, pursuant to Rule 460 of the General Rules and Regulations under the Securities Act of 1933, as amended (the “Act”), the underwriters have distributed approximately 1,500 copies of the Preliminary Prospectus dated April 26, 2021 through the date hereof, to underwriters, dealers, institutions and others.

We, the undersigned Representatives, have been informed by the participating underwriters that they will comply with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934, as amended, in connection with the proposed offering.

In accordance with Rule 461 of the Act, we hereby join in the request of the registrant that the effectiveness of the above-captioned Registration Statement, as amended, be accelerated to 4:00 p.m. Eastern Time, on April 29, 2021 or as soon thereafter as practicable, unless Vaccitech plc or its outside counsel, Goodwin Procter LLP, request by telephone that such Registration Statement be declared effective at some other time.

[signature page follows]

Very truly yours,
Morgan Stanley & Co. LLC
Jefferies LLC
Barclays Capital Inc.
William Blair & Company, L.L.C.
For themselves and as representatives
of the syndicate of underwriters for the offering
By Morgan Stanley & Co. LLC
By:	/s/ Kalli Dircks
	Authorized Representative
By Jefferies LLC
By:	/s/ Charlie Glazer
	Authorized Representative
By Barclays Capital Inc.
By:	/s/ Victoria Hale
	Authorized Representative
By William Blair & Company, L.L.C.
By:	/s/ Rakhee Bhagat
	Authorized Representative

[Signature Page to Acceleration Request of the Underwriters]