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Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Dec. 31, 2021
Cash flows from operating activities:          
Net loss $ (19,011) $ (12,941) $ (55,366) $ (33,592)  
Adjustments to reconcile net loss to net cash used in operating activities:          
Depreciation and amortization     1,029 435  
Accretion and amortization of marketable securities, net     (621) 378  
Amortization of right-of-use assets     580    
Asset impairment     235    
Stock-based compensation expense     8,084 2,784  
Fair value adjustment of contingent stock liability       735  
Changes in operating assets and liabilities:          
Prepaid and other current assets     (1,634) (2,229)  
Other assets     (7) (92)  
Accounts payable     (215) 210  
Accrued expenses     1,260 1,213  
Operating lease liability     (423)    
Other liabilities     91    
Net cash used in operating activities     (46,987) (30,158) $ (40,000)
Cash flows from investing activities:          
Purchases of property and equipment     (2,774) (1,248)  
Purchases of marketable securities     (140,588) (210,789)  
Maturities of marketable securities     190,021 114,929  
Net cash provided by (used in) investing activities     46,659 (97,108)  
Cash flows from financing activities:          
Proceeds from isuance of common stock       139,523  
Payment of partial settlement of contingent stock liability       (277)  
Proceeds from exercise of stock options     105 111  
Net cash provided by financing activities     182 136,988  
Net increase (decrease) in cash and cash equivalents     (146) 9,722  
Cash and cash equivalents at beginning of period     18,614 17,589 17,589
Cash and cash equivalents at end of period $ 18,468 $ 27,311 18,468 27,311 $ 18,614
Supplemental disclosure of non-cash investing and financing activities:          
Property and equipment additions included in accounts payable and accrued expenses     178 252  
Deferred issuance costs included in accounts payable and accrued expenses     81    
Issuance of shares of common stock in partial settlement of conttingent stock liability       831  
2021 Employee Stock Purchase Plan          
Cash flows from financing activities:          
Proceeds from isuance of common stock     $ 77    
Common Stock          
Cash flows from financing activities:          
Common stock issuance costs       $ (2,369)