Income taxes - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Operating Loss Carryforwards [Line Items]
Deferred tax asset valuation allowance	$ 85,642	$ 56,706
Change in Valuation Allowance	28,900
state net operating loss carryforwards	200
Tax credit limitation on use		The federal and state net operating losses can be carried forward indefinitely, subject to an 80% limitation against taxable income. The state net operating losses will begin to expire in 2042, unless previously utilized.
Tax Credit Carryforward, Amount	7,800
Orphan Drug Credit	$ 3,900
Use of annual operating loss carryforwards	Sections 382 and 383, annual use of the Company’s net operating loss carryforwards may be limited in the event a cumulative change in ownership of more than 50% occurs within a three-year period.
CARES Act NOL carryover/carryback offset to taxable income.	50.00%
Unrecognized tax benefits	$ 3,602	$ 1,968	$ 1,011
Domestic Tax Authority
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards Expiration Period	2040
orphan drug credit carryforwards Expiration Period	2041
Domestic Tax Authority | Research and Development Tax Credit
Operating Loss Carryforwards [Line Items]
Federal net operating loss carryforward	$ 119,200
California Franchise Tax Board | Research and Development Tax Credit
Operating Loss Carryforwards [Line Items]
Tax Credit Carryforward, Amount	$ 2,700