Unaudited Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities
Net loss	$ (78,939)	$ (72,012)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	901	1,016
Loss on disposal of property and equipment	6	4
Gain on extinguishment of debt		(690)
Stock-based compensation	11,062	21,307
Accrued interest		3
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(2,876)	(1,516)
Accounts payable and accrued expenses	4,146	10,844
Right-of-use assets and lease liabilities, net	(373)	(221)
Net cash used in operating activities	(66,073)	(41,265)
Cash flows from investing activities
Purchases of property and equipment	(237)	(835)
Proceeds from sale of property and equipment	3
Net cash used in investing activities	(234)	(835)
Cash flows from financing activities
Payment of initial public offering costs		(1,911)
Proceeds from issuance of common stock		75,001
Proceeds from exercise of stock options		140
Proceeds from issuance of common stock under Employee Stock Purchase Plan	19	190
Payments for taxes related to net settlement of equity awards	(571)
Net cash provided by (used in) financing activities	(552)	73,420
Net increase (decrease) in cash and cash equivalents	(66,859)	31,320
Cash and cash equivalents, beginning of period	244,979	238,605
Cash and cash equivalents, end of period	178,120	269,925
Supplemental disclosure of non-cash investing and financing activities
Property and equipment additions included in accounts payable and accrued expenses	1	8
Equity issuance costs included in accounts payable and accrued expenses		3,947
Tax related to net settlement of equity awards included in accounts payable and accrued expenses	$ 49