Unaudited Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities
Net loss	$ (53,160)	$ (49,082)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	601	636
Loss on disposal of property and equipment	6	4
Stock-based compensation	7,474	16,941
Accrued interest		3
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(2,595)	(2,646)
Accounts payable and accrued expenses	5,849	5,716
Right-of-use assets and lease liabilities, net	(232)	(111)
Net cash used in operating activities	(42,057)	(28,539)
Cash flows from investing activities
Purchases of property and equipment	(179)	(736)
Proceeds from sale of property and equipment	3
Net cash used in investing activities	(176)	(736)
Cash flows from financing activities
Payment of initial public offering costs		(1,911)
Proceeds from issuance of common stock under Employee Stock Purchase Plan	19	190
Payments for taxes related to net settlement of equity awards	(475)
Net cash used in financing activities	(456)	(1,721)
Net decrease in cash and cash equivalents	(42,689)	(30,996)
Cash and cash equivalents, beginning of period	244,979	238,605
Cash and cash equivalents, end of period	202,290	207,609
Supplemental disclosure of non-cash investing and financing activities
Property and equipment additions included in accounts payable and accrued expenses	33	42
Tax related to net settlement of equity awards included in accounts payable and accrued expenses	$ 18