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Income taxes - Schedule of Income Tax Reconciliation (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Tax Disclosure [Abstract]    
Tax computed at the federal statutory rate $ (20,034) $ (7,529)
Deferred impact of conversion to C Corporation (2,131) (6,708)
Partnership income not subject to tax   1,837
Nondeductible executive compensation 4,145  
Stock-based compensation (1,021)  
Research and development and orphan drug credits (3,091) (807)
Uncertain tax positions 757 197
Other, net 793 242
Valuation allowance 20,582 12,768
Income tax expense $ 0 $ 0